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In the last decade of the 19th century, the first group of missionary sisters of the Congregation of the Dominican Sisters of St. Catherine of Siena from Madrid arrived and joined the Beatas in Manila. Then, during the Japanese occupation, sometime in May or June 1943, the small community of the Dominican Sisters of St. Catherine of Siena occupied an old house which as just brought at Legarda St., Sampaloc, Manila as its convent. However, as Manila was about to be liberated from the Japanese, the Mother General decided that the community be evacuated to Bulacan, Bulacan the hometown of Sr.Amada Lopez, O.P. Other well-to-do families of the town helped the sisters in maintaining the place.
On December 1943, as fighting between the Huks USAFFE was going on, the parish priest of Bulacan, Bulacan, Reverend Father Gutierrez, gave the convent to the Dominican
Community. He was later, executed by the Huks on Christmas Eve. Between December 25, 1943 to April 1944, the sisters were gripped with fear on the Huks who every now and then asked
food, clothing and anything from them.
The Mother General decided to leave the place, Sisters Cecilia Sison and Patrocinio Mallari went from there to Pulilan, Bulacan to look for an accommodation. The parish
priest, Reverend Fr. Deogracias R. Javier and several pious women like Dona Sale, Dona Marta, Ms. Milagros Calderon received the sisters with open arms. The community was first
housed at the rectory and later on transferred to the house of Ms. Calderon until after the American liberation. At the prodding of the town mayor, Mr. Fausto Aguirre, the
Dominican sisters set up in the town a small school for Catholic education. The good ladies and Dona Poten provided the sisters with everything they needed. Ms. Leona San Pedro
volunteered to recruit children for kindergarten and first year high school. One half of the convent was given by Fr. Deogracias Javier to be used as classrooms. And there began the very first foundation of St. Dominic Academy with Rev. Mo. Carmen Cailles, O.P. as the first superior of the little community. She was succeeded by Rev. Mo. Rosario Razon, O.P. in 1950.
On June 1950, the Congregation of Dominican Sisters of Catherine of Siena formally took over the administration of St. James Academy in Plaridel, Bulacan with Msgr. Honorio Resurreccion as its co-founder. The school derived its name after St. James, the Apostle, the town's Patron Saint.