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Potencies

To give you an idea of the antifungal potencies of the compounds presented here, the minimal inhibitory concentrations (in microgramm/millilitre) are given for four different fungi: Saccharomyces cerevisiae BY4743 (S.c.), Candida albicans SC5314 (C.a.), Candida glabrata (C.g.) and Candida parapsilosis (C.p.).

   

S.c.

C.a.

C.g.

C.p.

Commercial Antifungals:

Amphotericin B

0.6

0.6

2.5

0.05

 

Clotrimazol

2.5

0.05

0.6

0.05

Unsubstituted Amine:

Amine 10

6.3

3.1

1.6

0.8

N-substituted Amines:

N-Ethylamine 74

0.1

0.4

0.1

0.1

 

N-Allylamine 75

0.05

0.2

0.1

0.05

alpha-substituted Amines:

Homoallylamine 32

0.02

0.2

0.1

0.05

 

Cyclohexylamine 38

<0.01

0.05

0.1

0.05

Amidines:

4-Chlorophenylamidine 58

0.8

0.8

0.8

0.4

 

Pyrrolidineamidine 60

3.1

1.6

1.6

3.1

7-Amino-des-A,B-cholestanes:

Methylaminino... 47

6.3

3.1

0.8

1.6

 

Isobutylamino... 48

0.8

6.3

1.6

1.6

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