Mechanism of action: has two-fold mechanisms; it enhances peripheral muscle glucose uptake and utilization and inhibits glucose release from the liver.

Major side effects: GI intolerance, anorexia, epigastric fullness, photosensitivity, dyspepsia, and dysgeusia (metallic taste).

Biguanide Agent	Brand Names	Drug Interaction	Contraindication	Dosage	Costs per Month
Metformin	Glucophage	Furosemide Nifedipine Cationic Drugs	Renal disease Hypersensitivity	500mg tid 850mg bid 1g bid	500mg tid: $50.00 - 59.99