“Gram scale synthesis” does not exactly appear to be a very exciting research area at first glance. This is not were Nobel prizes are won. But if you dare to take a closer look, it is not as boring as it seems:

1. It is challenging to find more efficient and reliable synthetic pathways for known compounds.

2. It is important to supply certain substances to the scientific community.

3. As I work with many diffent types of compounds, I use a broad variety of methods, from century old liquid phase chemistry to state-of-the-art metallo-organic systems and microwave assisted synthesis.

One focus of my research was the application of microwave irradiation to chemical reactions as a source of energy. Some of my published work deals with that aspect:

J. Burbiel, J. Hockemeyer, C.E. Müller, “Synthesis of xanthine derivatives by microwave-assisted ring closure reaction”, ARKIVOC (ii) 77-82 (2006) (view as pdf (external link))

J. Burbiel, J. Hockemeyer, C.E. Müller,  “Microwave-assisted ring closure reactions: synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones”, Beilstein Journal of Organic Chemistry 2:20 (2006) (view article (external link))

Examples of the substances I have synthesised at a gram scale:

Two further publication in the field of gram scale synthesis:

J. Burbiel, M. Thorand, C.E. Müller, “Improved, efficient synthesis for multigram-scale production of PSB-10, a potent antagonist at human A3 adenosine receptors“, Heterocycles 60 (6), 1425-1432 (2003)

J. Hockemeyer, J. Burbiel, C.E. Müller, ”Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson´s disease”, J. Org. Chem. 69 (10), 3308-3318 (2004)

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