The present Siquijor State College started in 1920 as a General High School offering only the first and second year levels, one section per curriculum year level with only two teachers including the principal. Then called the Larena High School, it was under the supervision of the Negros Oriental Provincial High School in Dumaguete City. Nine years later (1929) it operated as a complete secondary school and was renamed the Larena Sub-Provincial High School.
Only July 1, 1960, by virtue of Republic Act No. 2423, the school was converted into a vocational school offering the Secondary Trades Curriculum. This time the school was called the Larena National Vocational School (LNVS). As the only vocational school in the province, it offered collegiate technical courses and evening opportunity classes.
The dream of the administration for the full conversion of the Larena National Vocational School into a college was realized when the National Assembly approved Batasang Pambansa Blg. 387 on April 14, 1983 and LNVS became the Larena National Vocational College (LNVC). Since this law authorized the offering of collegiate courses, the Bachelor of Science in Industrial Education (BSIE) and the Bachelor of Science in Industrial Technology (BSIT) were offered in 1985 and seven years after (1992) the Bachelor of Science in Marine Engineering. In 1994 additional courses were offered, namely: Bachelor in Elementary Education (BEEd), Bachelor in Secondary Education (BSEd), Bachelor of Science in Marine Transportation (BSMT), Bachelor of Science in Hotel and Restaurant Management (BSHRM) and the Bachelor in Business Administration (BBA).
To cater the needs of the employees in the province who had to cross the rough seas in order to upgrade themselves, the college offered Graduate Programs in 1993 with two degrees; namely: Master of Arts in Educational Management (MAEM) and the Master of Arts in Industrial Education (MAIE) and in 1997, the Master in Public Management (MPM).
On March 3, 1995, the passage of Republic Act No. 7947 finally converted LNVC into a chartered state college. In answer to the call for higher technology additional courses were offered, viz: Associate in Computer Science (1996), Bachelor of Science in Computer Technology (1999) and very recently (2000) the Bachelor of Science in Marine Biology.