ChE 2002 November 8 -12 Pucón - Chile PROGRAM TOPICS PROGRAM REGISTRATION FEES  GENERAL INFORMATION CHILE INFORMATION  HOTEL ACOMODATION REGISTRATION FORM CALL FOR ABSTRACTS  HOTEL RESERVATION   Secretariat Last update: 05.03.2002 Diseño O. Giordano                                                                                                                                 RETURN TO TOP

VIIth International Meeting on Cholinesterases November 8 -12 - 2002 - Pucon - Chile   PROGRAM • Friday, November 8, 2002 13:00- 18:00 Registration 18:00-18:15 Opening Ceremony 18:15-19:15 Plenary Lecture: MARCEL MESULAM, USA, Cholinesterases in Health and Disease 19:30-21:00 Reception for All Participants • Saturday, November 9, 2002 Session 1 Chairperson: Jean Massoulie, France 08:30 MOLECULAR ORGANIZATION AND FUNCTIONAL LOCALIZATION OF AChE J. MASSOULIE, France 08:50 FINE LOCALIZATION OF AChE AT THE NEUROMUSCULAR JUNCTION (NMJ) L. ANGLISTER, Israel 09:10 CONTROL OF EXPRESSION OF AChE IN THE DEVELOPING NMJ HUMAN SKELETAL MUSCLE IN VITRO Z. GRUBIC, Slovenia 09:30 ORGANIZING AChE MOLECULES AT THE NMJ R.L. ROTUNDO, USA 09:50 CONTROL OF AChE IN SKELETAL MUSCLES J. SKETELJ, Slovenia 10:10 Coffee Break 10:40 SYNAPTIC TRANSMISSION AT AChE- AND ColQ- KNOCKOUT MOUSE NEUROMUSCULAR JUNCTION J. MOLGO, France 10:55 CONTROL OF AChE AND ITS REGULATION BY DEPOLARIZATION S. ROSSI, USA 11:10 EVENTS CONTROLLING EXPRESSION OF AChE IN SKELETAL MUSCLE B.J. JASMIN, Canada 11:25 TRANGENIC AND DIFFERENT EXONS KNOCKOUT OF AChE S. CAMP, USA 11:40 PRIMA, THE ANCHOR DOMAIN OF BRAIN AChE E. KREJCI, France 11:55 AChE IS REQUIRED FOR NEURONAL AND MUSCULAR DEVELOPMENT IN THE ZEBRAFISH EMBRYO X. COUSIN, France 12:15-14:15 Lunch Session 2 Chairperson: Palmer Taylor, USA 14:30 GENETIC AND STRUCTURAL APPROACHES TO ChE EXPRESSION AND FUNCTION P. TAYLOR, USA 14:50 THE ROLE OF AROMATIC TRAPPING OF HIS 447 ON CATALYSIS OF AChES A. SHAFFERMAN, Israel 15:10 MOLECULAR RECOGNITION IN AChE CATALYSIS- THE VIEW FROM NEAR AND FAR D.M. QUINN, USA 15:30 UNMASKING TANDEM INTERACTION BETWEEN SUBSTRATE BINDING SITES ON THE CATALYTIC PATHWAY OF HUMAN AChES T.L. ROSENBERRY, USA 15:50 SHORT STRONG HYDROGEN BONDS AT THE ACTIVE SITE OF ChE I.M. KOVACH, USA 16:00 PARTIALLY UNFOLDED STATES OF ACETYLCHOLINESTERASE: RULE OR EXCEPTION? L. WEINER, Israel 16:10 Coffee Break 16:30 KINETICS OF ETHOPROPAZINE BINDING TO BChE IN THE ABSENCE AND PRESENCE OF ACETYLTHIOCHOLINE E. REINER, Croatia 16:50 ChE HYSTERESIS: KINETIC CURIOSITY OR CATALYTIC AND PHYSIOLOGICAL RELEVANCE P. MASSON, France 17:10 ANALYSIS OF AChE ADDUCTS OF ALZHEIMER´S DRUGS A. ORDENTLICH, Israel 17:30 MONITORING ChE-LIGAND INTERACTIONS Z. RADIC, USA 17:50 PHOSPHORYLATION AND AGING OF AChE – INSIGHTS FROM MUTAGENESIS, MASS SPECTROMETRY AND STRUCTURAL STUDIES. D. BARAK, Israel 18:30-20:30 Poster Session I 20:30-22.00 Dinner • Sunday, November 10, 2002 Session 3 Chairperson: Jean- Pierre Toutant, France 08:30 NEW BIOSENSORS FOR IMPROVED DETECTION OF ENVIRONMENTAL CONTAMINATION BY AChE PESTICIDES J.-P. TOUTANT, France 08:45 BIOENGINEERING Drosophila AChE D. FOURNIER, France 09:00 AChE BIOSENSORS J.L. MARTY, France 09:15 AChE GENES IN C. elegans M. ARPAGAUS, France 09:30 TWO GENES CODE FOR AChE IN INSECTS M. RAYMOND, France 09:45 AChE GENES OF MYZUS AND INSENSITIVITY TO PESTICIDES G. MOORES, UK 10:00 IMMOBILIZED BChE AND DECONTAMINATING MATRICES R.K. GORDON, USA 10:15 Coffee Break 10:45 BIOSCAVENGERS: ANTIDOTES FOR ORGANOPHOSPHATE CHEMICAL WARFARE AGENT TOXICITY. B.P. DOCTOR, USA 11:00 BChE, A PROPHYLACTIC AGAINST ORGANPHOSPHORUS POISONS D.E. LENZ, USA 11:15 STRATEGY FOR THE REACTIVATION OF ORGANOPHOSPHATE-INHIBITED HUMAN BUTYRYLCHOLINESTERASE CH. LUO, USA 11:30 INTERACTION OF DRUGS AND ENVIRONMENTAL FACTORS WITH BIOSCAVENGERS: DOES FLUORIDE IN HUMAN PLASMA AFFECT THE ANTIDOTAL PROPERTIES OF HUMAN BUTYRYLCHOLINESTERASE? Y. ASHANI, Israel 11:45 THE HIERARCHY OF POST-TRANSLATION MODIFICATIONS DETERMINING CIRCULATORY LONGEVITY OF AChE B. VELAN, Israel 12:00 HUMAN SERUM BUTYRYLCHOLINESTERASE: A FUTURE GENERATION ANTIDOTE FOR ORGANOPHOSPHATE CHEMICAL WARFARE AGENT TOXICITY A. SAXENA, USA 12:15 ACETYLCHOLINESTERASE PROMOTES AMYLOID PLAQUES IN TRANSGENIC MOUSE BRAIN S. BRIMIJOIN, USA 12:30-14:00 Lunch 14:00 Poster Session II 16:15 Presentation of Selected Posters 17:00 CHILEAN STYLE BARBICUE • Sunday, November 10, 2002 Session 4 Chairperson: Ezio Giacobini, Switzerland 08:30 LONG TERM EFFICACY OF ChEI IN ALZHEIMER : AN EFFECT ON b- AMYLOID METABOLISM? E. GIACOBINI, Switzerland 08:50 A NEW GENERATION OF ChE INHIBITORS WITH AMYLOID-MODIFYING PROPERTIES D.K. LAHIRI, USA 09:10 AChE-AMYLOID b PEPTIDE INTERACTION G. DE FERRARI, Chile 09:30 ChES INHIBITORS ARE NOT ALL ALIKE Z. RAKONCZAY, Hungary 09:50 ChES: THEIR ROLES IN THE PATHOGENESIS AND DIAGNOSIS OF ALZHEIMER´S D.L. SMALL, Australia 10:10 BChE INHIBITION AS A TREATMENT STRATEGY FOR ALZHEIMER´S N. GREIG, USA 10:30 Coffee Break 11:00 THE ROLE OF A PEPTIDE DERIVED FROM AChE IN NEURODEGENERATION S. GREENFIELD, UK 11:20 FASCICULIN USES IN NEUROCHEMISTRY F. DAJAS, Uruguay 11:40 DIRECT EVIDENCE FOR AN ADHESIVE FUNCTION IN THE NONCHOLINERGIC ROLE OF AChE IN NEURITE OUTGROWTH J.W. BIGBEE, USA 12:00 MAJOR HALLMARKS IN ALZHEIMER´S DISEASE CAN BENEFICIALLY BE MODULATED BY M1 MUSCARINIC AGONISTS – AN ADDED VALUE VS. CHOLINESTERASE INHIBITORS A. FISHER, Israel 12:20 CHOLINERGIC PATHWAYS C.A. CUELLO, Canada 12:45-14:15 Lunch Session 5 Chairperson: Israel Silman, Israel 14:30 STRUCTURAL STUDIES WITH AChE AND BChE I. SILMAN, Israel 14:50 CRYSTAL STRUCTURE OF THE TETRAMERIZATION DOMAIN OF AChE M. HAREL, Israel 15:10 COMPARATIVE STUDIES OF Torpedo AND HUMAN AChE J. SUSSMAN, Israel 15:30 CRYSTAL STRUCTURE OF THE HUMAN BChE J.C. FONTECILLA-CAMPS, France 15:50 LATEST INSIGHTS INTO LIGAND INTERACTIONS AT THE AChE PERIPHERAL ANIONIC SITE Y. BOURNE, France 16:10 Coffee Break 16:30 INSIGHTS INTO THE INTERACTIONS AT THE AChE PERIPHERAL ANIONICSITE P. MARCHOT, France 16:50 PROBES FOR INVESTIGATION OF CHOLINERGIC PROTEINS M. GOELDNER, France 17:10 INTERACTION OF TOXINS WITH CHOLINERGIC PROTEINS J. ANGLISTER, Israel 17:30 STRUCTURAL ANALYSIS OF MEMBRANE PROTEINS M. WEIK, France 18:30-20:30 Poster Session II 20:30-22.00 Dinner • Tuesday, November 12, 2002 Session 6 Chairperson: Hermona Soreq, Israel 09:30 LIFE WITHOUT ACETYLCHOLINESTERASE O. LOCKRIDGE, USA 09:50 BIFUNCTIONAL COMPOUNDS ELICITING BOTH ANTI-ChE AND ANTI-INFLAMMATORY ACTIVITY G. AMITAI, Israel 10:10 BRAIN IMAGING: A WINDOW ON FUNCTION, DISEASE AND THERAPY A. NORDBERG, Sweden 10:30 A NOVEL NEUROPROTECTIVE TRIFUNCTIONAL ChE INHIBITOR FOR TREATMENT OF DEMENTIA M.B.H. YOUDIM, Israel 10:50 AChE AS A WINDOW TO STRESS RESPONSE H. SOREQ, Israel 11:10 CLOSING REMARKS R.D. ROTUNDO, USA 12:00 Lunch || Program Topics||  Timetable ||  Registration Fees||  Information || || Chile Information  ||  Contact ||  Hotel Acomodation || Call for Abstracts ||  Home  ||