| * denotes home games. | |||||||||||
| 1920 (4-5-1) | 1921 (5-2) | ||||||||||
| Coach: M.B. Banks | Coach: Ossie Solem | ||||||||||
| William Penn | W | 54-0 | William Penn | W | 42-0 | ||||||
| Simpson* | W | 66-0 | Kansas | W | 15-7 | ||||||
| Illinois | L | 0-41 | Cornell (Iowa)* | W | 41-0 | ||||||
| Kansas | L | 3-7 | Missouri | L | 0-6 | ||||||
| Missouri* | L | 7-10 | Iowa State* | L | 0-7 | ||||||
| Grinnell | T | 6-6 | Morningside | W | 30-10 | ||||||
| Washington (Mo.) | W | 14-6 | Grinnell* | W | 21-10 | ||||||
| Creighton | W | 7-0 | |||||||||
| Morningside | L | 6-14 | |||||||||
| Oklahoma* | L | 7-44 | |||||||||
| 1922 (7-0) | Missouri Valley Co-Champion | 1923 (5-2) | |||||||||
| Coach: Ossie Solem | Coach: Ossie Solem | ||||||||||
| O8 | Cornell (Iowa)* | W | 16-0 | Cornell (Iowa)* | W | 20-0 | |||||
| O14 | Kansas* | W | 6-0 | Missouri-Rolla* | W | 54-0 | |||||
| O21 | Washington (Mo.) | W | 31-7 | Grinnell | W | 41-0 | |||||
| N4 | Iowa State* | W | 14-7 | Iowa State* | W | 21-0 | |||||
| N11 | Colorado State* | W | 19-6 | Coe* | L | 6-12 | |||||
| N18 | Grinnell* | W | 21-0 | Kansas | L | 0-17 | |||||
| N25 | Mississippi State | W | 48-6 | Oklahoma | W | 26-20 | |||||
| 1924 (5-2-1) | 1925 (5-3) | First Year For Drake Stadium | |||||||||
| Coach: Ossie Solem | Coach: Ossie Solem | ||||||||||
| Utah | W | 33-14 | Washington (Mo.) | W | 6-0 [1] | ||||||
| Knox* | W | 19-10 | O10 | Kansas State* | W | 19-0 | |||||
| Grinnell* | W | 13-0 | Oklahoma | L | 0-7 | ||||||
| Oklahoma* | W | 28-0 | Grinnell | W | 7-6 | ||||||
| Kansas* | T | 6-6 | Kansas | W | 7-0 | ||||||
| Kansas State | W | 7-6 | Nebraska* | W | 14-0 | ||||||
| Iowa State | L | 0-10 | Iowa State* | L | 6-7 | ||||||
| Florida | L | 0-10 | Southern Methodist | L | 8-21 | ||||||
| 1926 (2-6) | 1927 (3-6) | ||||||||||
| Coach: Ossie Solem | Coach: Ossie Solem | ||||||||||
| Nebraska | L | 0-21 | Simpson* | W | 20-6 | ||||||
| Navy [2] | L | 7-24 | Navy | L | 6-35 | ||||||
| Oklahoma* | L | 0-11 | Pittsburgh* | L | 0-32 | ||||||
| Mississippi* | W | 33-15 | Grinnell | W | 26-6 | ||||||
| Kansas* | W | 13-0 | Kansas | L | 6-7 | ||||||
| Iowa* | L | 7-13 | Iowa State* | L | 0-7 | ||||||
| Notre Dame | L | 0-21 | Minnesota | L | 6-27 | ||||||
| Grinnell | L | 0-13 | Notre Dame* | L | 0-32 | ||||||
| UCLA | W | 25-6 | |||||||||
| 1928 (7-1) | Missouri Valley Champion | 1929 (5-3-1) | Missouri Valley Co-Champion | ||||||||
| Coach: Ossie Solem | Coach: Ossie Solem | ||||||||||
| O6 | Simpson* | W | 40-6 | Simpson* | W | 39-0 | |||||
| Marquette | W | 26-7 | Oklahoma State* | W | 18-6 | ||||||
| Grinnell* | W | 19-7 | Washington (Mo.) | W | 20-0 | ||||||
| Notre Dame | L | 6-32 | Missouri | L | 0-20 | ||||||
| Missouri | W | 6-0 | Grinnell* | T | 6-6 | ||||||
| Washington (Mo.)* | W | 20-0 | Creighton* | W | 34-12 | ||||||
| Iowa State | W | 18-0 | Notre Dame | L | 7-19 | ||||||
| Creighton | W | 6-0 | at Soldier Field, Chicago | ||||||||
| Iowa State | W | 7-0 | |||||||||
| [1] Drake lists score of 1925 Washington game as 5-0. | Temple | L | 14-16 | ||||||||
| [2] Following the Drake game, Navy def. Richmond on the same day. | |||||||||||
