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1949 ,y; fdlh cstpahyhsu; nlhdhy;L X n`g; (Donald O hebb)
xU vspa tpsf;fj;jpd; %yk; epidTfs; vg;gb Nrkpf;fg;gLfpd;wd
vd;W fhl;bdhu;. mJ n`g;gpd; mwpT tpjp vdg;gLfpwJ.
njhlu;G nfhz;Ls;s epAuhd;fs; (euk;G nry;fs;) xNu rkaj;jpy;
J}z;lg;gl;L nraw;gLk; NghJ epidT gjpfpwJ my;yJ gpwf;fpwJ.
mj;njhlu;G ePbf;Fkl;by; epidT ePbf;fpwJ.
,uz;L epAuhd;fs; njhl;Lf;nfhs;Sk; ,lj;ij rpndg;];
(synepse)
vd;ghu;fs;. rpndg;]py; epAuhd;fspw;F ,ilapy;
rpW ,ilntsp ,Uf;fpwJ. Kjy; rpndg;]py; ,Ue;J xU ,urhazg;gjhu;j;jk;
frpe;J kW rpndg;]py; njhlu;G Vw;gLj;Jtjhy; J}z;lNyw;gLfpwJ.
n`g;gpd; Nfhl;ghl;bw;F 1973 ,y; jhd; Neub ep&gzk;
fpilj;jJ. M]Ny gy;fiyf;fof Nkijfs; (V.P Bliss, Terge
Lomo ) Nrhjid %yk; ,jidf; fhl;bdu;.
%isapy; `pg;Ngh Nfk;g;]; vd;W xU gFjp ,Uf;fpwJ. ,q;fpUe;J
vLf;fg; gl;l euk;G nry;fspw;F cau; mjpu;ntz; nfhz;l
nkd;ikahd kpd; Jbg;Gfis mDg;gpa NghJ ,tw;wpd; rpndg;];
,izg;Gfs; tYg;ngWtij mtjhdpj;jdu;. ,e;epfo;it ePbj;j
fpsu;r;rp (Long
term Potention) vd;wdu;. rpndg;]; njhlu;G thuf;fzf;fpy;
$l epiyj;jpUg;gij fz;ldu;.
`pg;Ngh Nfk;g;]; gFjpapy; LTP
,Ug;gJ xU tpag;ghd cz;ikahf ,Uf;fpd;wJ. Vnddpy;
%isapy; epidTfs; cUthf `pg;Ngh Nfk;g;]; kpfTk; mj;jpahtrpakhd
cWg;G.
khu;f;. gpau; vd;w N`thu;L gy;fiyf;fof kUj;Jtu; mNj
`pg;Ngh Nfk;g;]; gFjpf;F Fiwe;j mjpu;ntz; kpd; J}z;ly;
jUk; NghJ ePbj;j jsu;r;rp epiy Vw;gLtij fz;Lgpbj;jdu;.
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mjd;gpwF LTP
kw;Wk; LTD
Mfpa Kiwapy;jhd; Qhgfk; Nrkpf;fg;gLtijAk; Qhgfk; kwe;J
NghtjhfTk; tpQ;Qhdpfs; ek;gj; njhlq;fpdu;fs;. LTP
kw;Wk; LTD
Mfpait `pg;Ngh Nfk;g;]; kl;Lkpd;wp epNahfhu;l;nlf;];
(fpNu Nkl;lu;)> mkpf;nlyh Nghd;w mwpT rk;ge;jg;gl;l
gFjpfspYk; njhopw;gLtJ njupe;jJ.
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rpndg;]; ,izg;G njhlu;ghdJ tYtiltj;w;Fk; eyptiltjw;Fk;
mbg;gil fhuzk; vd;d vd;gJ %yf;$W mstpy; 1980 - 1990
tiu eilngw;w Ma;Tfspy; gpd;tUkhW tpsf;fg;gl;lJ.
rpndg;]; gFjpapy; ,uz;L epAuhd;fs; re;jpf;fpd;wd. epidT
vg;gb Nrkpf;fg;gLfpd;wJ vd;gjw;F
NMDA Vw;gp vd;w gpd; rpndg;]; nry; rt;tpy; mku;e;jpUf;Fk;
4 Guj njhFg;Gj;jhd; fhuzk; vd;W fUjg;gLfpwJ.
NMDA vd;w Vw;gpapd; Jis topahf fy;rpak; EisAk;.
,jdhy; xNu Neuj;jpy; ,uz;L epfo;r;rpfs; ,izf;fg;gLfpd;wd.
,Jjhd; epidtpw;F mbg;gil. Kd; rpndg;]pypUe;J tUk; F@lhnkl;
xl;Ljy; Kjy; epfo;r;rp> mNj Neuj;jpy; kw;nwhU epAuhdpypUe;J
fpilf;Fk; kpd; J}z;ly;> ,d;ndhU epfo;r;rp ,uz;bdhYk;>
fy;rpak; cs; Eise;J gw;gy tpisTfis Vw;gLj;jp rpndg;];
njhlu;ig tYg;gLj;Jfpd;wd.
,jd; ,d;ndhU Muha;r;rpahd ^fp vd;w n[dbf; vQ;Qupaq;
vyp Fwpj;j Ma;Tfs; mLj;j ,jopy;. |
thd; ,af;ftpay;