What causes Hand-Foot-Mouth Disease?

Hand-Foot-Mouth Disease is caused by a group of viruses known as enteroviruses. The enterovirus called coxsackie virus A16 is the most common cause of HFMD. However, in some cases, other enteroviruses can also cause HFMD.Oral ingestion is the main source of coxsackievirus infection and hand-foot-and-mouth disease. The illness spreads by person-to-person contact with an infected person.