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Scientists ID flu virus on money Virus That Infects Cancer Cells - Yahoo! News
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Scientists ID Virus That Infects Cancer Cells
Tue Oct 14, 7:03 PM ET
TUESDAY, Oct. 14 (HealthDay News) -- New details about the structure of a virus that can infect lung cancer cells have been uncovered by researchers at the Scripps Research Institute in California.
The findings may help scientists find ways to alter the virus so that it attacks other tumor subtypes.
The Scripps team said the 3-D structure of the Seneca Valley Virus-001 reveals that it's unlike any other known member of the Picornaviridae viral family and confirms its recent designation as a separate genus, Senecavirus.
The outer protein shell of Senecavirus looks like a craggy golf ball (with uneven divets and raised spikes), and the RNA strand beneath the shell is arranged in a windows virus protection round mesh, the Scripps study found.
"It is not at anti virus review all like other known picornaviruses that we are familiar with, including poliovirus and rhinovirus, which cause the common cold," study senior author Vijay S. Reddy, said in a Scripps news release. "This crystal structure will now help us understand how Senacavirus works, and how we can take advantage of it."
Reddy and colleagues also identified several areas on the virus's protein shell that may hook onto receptors on cancer cells in the process of infecting them. They're now taking a closer look at this process.
"It will be critically important to find out what region of its structure the virus is using to bind to tumor cells, and what those cancer cell receptors are. Then we can, hopefully, improve Senecavirus enough to become a potent agent that can be used with many different cancers," Reddy said.
The study was published in the Oct. 8 issue of Structure.
The Senecavirus was identified a few years ago and win anti virus software is believed to have originated from cows or pigs. The virus is harmless to normal human cells but can infect certain solid tumors, such as small-cell lung cancer.
Laboratory and animal studies indicated that Senecavirus life virus has strong anti-cancer properties with little toxicity. A Intestine Virus U.S. biotech Virus Unable To Connect Block Internet company is currently testing the west nile virus scientific names virus in Virus Code Snippets early phase clinical trials with lung cancer patients.
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The National Cancer Institute has more about lung cancer.
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Why Are T Cells Tolerant To Hepatitis Ameba Stomach Virus B Virus?
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Why Are T Cells Tolerant To osx anti virus Hepatitis B Virus?
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Article Date: peripheral nevers virus 15 Oct 2008 - 2:00 PDT
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The level of PD-1 expression has been proved by recent studies to be positively correlated with the extent of HBV-specific T cell impairments. However, the degree of T cell exhaustion which affects the disease statuses of hepatitis B patients has so far been Symantic Anti Virus only evaluated in restricted and small groups of patients between those with established chronicity and subjects with acute HBV infection. Besides, whether levels of PD-1 expression on T cells differ between acute exacerbation of hepatitis B and chronic HBV infected patients is still unknown.
A research article published in the World Journal of Gastroenterology addresses this question. The research team led by Shu-Ling Zhang from Tongji Medical College of Huazhong University of Science and Technology in China examined the expression of PD-1 on antigen specific CD8+ T cells in peripheral blood of chronic hepatitis B (CHB) and acute exacerbation of hepatitis B (AEHB) patients.
They found that the levels of PD-1 on treatment of west nile virus total CD8+ T cells in CHB patients were significantly higher than those in AEHB patients and healthy individuals. Conversely, banya beethoven virus lower frequencies of HBV-specific CD8+ T cells were detected in samples from chronic patients compared to AEHB patients. Our results confirmed reports that HBV specific CD8+ T-cell responses in peripheral blood were macphee virus scanintensified in samples from AEHB patients than in those from patients with chronic hepatitis who remains viral persistence. Besides, there was a significant positive correlation between HBV viral load and percentage of PD-1 expression on CD8+ T cells in CHB and AEHB group of subjects. However, PD-1 expression was not in association with disease flare-ups indicator alanine aminotransferase (ALT). This study clarified the correlation between PD-1 expression and two different HBV infection statuses. ---------------------------- Article adapted by Medical News Today from original press release. ---------------------------- Reference: Ye P, Weng ZH, Zhang SL, Zhang JA, Zhao L, Dong JH, Jie SH, Pang R, Wei RH. PD-1 expression is associated with the disease statuses of hepatitis B virus infection. World J Gastroenterol 2008; 14(28): 4551-4557 http://www.wjgnet.com/1007-9327/14/4551.asp Correspondence to: Shu-Ling Zhang, Department of hepatology and infectious disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. About World Journal of Gastroenterology World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998. About The WJG Press The WJG Press mainly publishes World Journal of Gastroenterology. Source: Lai-Fu Li World Journal of Gastroenterology Pleasefree download virus protectionrate this article: (Hover over the stars then click to rate) Patient / Public: or Health Professional: Useful Links Email Print < Top Add to: Digg Del.icio.us Reddit Fark StumbleUpon Yahoo! HealthRanker Wikio Facebook Contact Our News Editors For any corrections of factual information, or to contact the editors please use our feedback form. 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