RAZZAQUE1

Curriculum Vitae of Mohammed S. Razzaque

PART I: General Information

Office Address:
Department of Developmental Biology,
Research and Educational Building, Room: 312,
Harvard School of Dental of Medicine,
188 Longwood Ave, Boston, MA 02115.
E mail: [email protected]
            [email protected]

Education:

1986     MD (in Medicine)         Chittagong University College of Medicine,
Chittagong, Bangladesh

1994     PhD (in Patholog)        Nagasaki University School of Medicine,
Nagasaki, Japan

Postdoctoral Training:

1986-1987
Internship     Departments of Medicine & Surgery,
Chittagong Medical College Hospital,
Chittagong, Bangladesh

1988
Attending Physician    Department of Nephrology,
Institute of Post-Graduate Medicine and
Research (IPGM&R), Dhaka, Bangladesh

1989-1990
Clinical Research Fellow    Division of Nephrology,
Department of Medicine, Nagasaki University Hospital,
Nagasaki, Japan

1990-1999
Surgical Pathologist    Department of Pathology,
Nagasaki University School of Medicine,
Nagasaki, Japan

1999-2000
Post-Doctoral Research Fellow     Division of Nephrology,
Pennsylvania State University College of Medicine,
Hershey, PA

Licensure and Certification:

1988     License from Bangladesh Medical and Dental Council (BMDC) for practicing Medicine
(License no. A 16855)

Academic Appointments:

2004-2006    Instructor     Department of Developmental Biology,
Harvard School of Dental of Medicine,
Boston, MA 02115.

2006-    Visiting Research Associate     Department of Pathology,
Nagasaki University School of Medicine,
Nagasaki 852-8523, Japan

2000-2003        Instructor     Department of Oral Medicine, Infection and Immunity,
Harvard School of Dental of Medicine,
Boston, MA 02115.

1994-2005     Instructor     Department of Pathology,
Nagasaki University School of Medicine,
Nagasaki 852-8523, Japan

Professional Society Members:

American Society of Bone and Mineral Research (2004); Association for Research in Vision and Ophthalmology (2001-present); International Cytokine Society (2001); The American Society of Nephrology (1997-present); The American Society of Hypertension (2000); Society of New York Academy of Sciences (1997-1998); The Japanese Society of Nephrology (1990-present); The Japanese Society of Pathology (1990-present); The Japanese Society of Histochemistry and Cytochemistry (1992-1995)

Editorial Board/Reviewer for Scientific Journals:

American Journal of Nephrology (2006-); Investigative Ophthalmology and Visual Sciences (2003-06); QJM (2006); Matrix Biology (2006), Biomacromolecules (2005); American Journal of Respiratory Cell and Molecular Biology (2004-05); Eurekah Bioscience (2005); Journal of American Society of Nephrology (2000-03); American Journal of Dermatopathology (2003); BMC Cell Biology (2004); Cell Biology International (2004); Kidney International (2002-04); Kidney and Blood Pressure Research (2003); Acta Histochemistry et Cytochemistry (1995, '97)

Scientific Grant Review:

Wellcome trust, UK (2004)

Awards and Honors:

1. Recipient of National Merit Scholarship (1974-1985).

2. Recipient of MONBUSHO scholarship from Ministry of Education, Science and Culture, JAPAN, for post-graduate study at Nagasaki University (April 1989-March 1994).

3. Recipient of Blue Ribbon Award at 29th annual meeting of American Society of Nephrology, New Orleans, USA, 1996

4. Recipient of travel grant for young investigators at 2nd International Forum- The Frontiers of Nephrology, Tokyo, JAPAN, 1998.

5. Recipient of travel grants for young investigators at 1st Annual Meeting of Federation of Clinical Immunology Societies (FOCIS), Boston, USA, 2001.

6. Recipient of travel grants for young investigators at 2nd Annual Meeting of Federation of Clinical Immunology Societies (FOCIS), San Francisco, USA, 2002.

7. Recipient of 2004 Dean's Certificate of Appreciation for service and contribution to Harvard School of Dental Medicine, Boston, USA.

8. Recipient of travel grant for 35th West Japan Congress of Nephrology, Nagasaki, JAPAN, 2005.

Research Grant Support:

1997-1998 (Grant no. 09670192)
Ministry of Education, Science and Culture, JAPAN.
Molecular mechanisms of renal scarring in human glomerulonephritis.
Role: Principal Investigator.

2000-2002 (Grant no. EY 08739)
NIH/NEI.
Ocular cicatricial pemphigoid: mechanism of pathogenesis
Role: Co-investigator.

2003-2004 (Grant no. EY 14228)
NIH/NEI.
Fibrogenic factors in ocular cicatricial pemphigoid.
Role: Co-investigator.

2007-2012
NIH/NIDDK.
In vivo interactions of FGF-23, klotho and Vitamin-D
Role: PI.

Patent/Invention
Inventor patent no Harvard Ref. 2561; Foley Ref. HMV-111.60 (pending); patent submitted through Harvard University, Boston, MA

Part II: Current Research and Teaching Experiences

A. Report of Current Research Activities

Bench research

1) Effects of renal electrolyte regulatory molecules on skeletogenesis.

2) Molecular mechanisms of conjunctival scarring in patients with ocular cicatricial pemphigoid.

3) Molecular mechanisms of glomerulosclerosis and tubulointerstitial fibrosis.

B. Report of Teaching Experiences

1994-1999     Department of Pathology,
Nagasaki University School of Medicine, Japan

Teaching role: attending, tutor and research guide     Renal Immunopathology
Type of students: Graduate and post-graduate students

2000-present    Department of Oral and Developmental Biology,
Harvard School of Dental Medicine, Boston

Teaching role: tutor and research instructor     Oral and Ocular Immunology
Type of students: Post-graduate students, and post-doctoral research fellows

2006-    Pre-doctoral Research Advisor

PART III: Bibliography

Books

Razzaque MS, Taguchi T. 2003. Renal Fibrosis; Contribution to Nephrology, Volume 139 (ISBN:3-8055-7568-8), KARGER PUBLISHERS, Basel, Switzerland.

     Book reviews/introductions are published in:
                         Kidney International, volume 64, page 1552, 2003
                         Virchows Archive,volume 444, page 98, 2004
                         Focus (http://focus.hms.harvard.edu), page 7, October 10, 2003
                         The National Medical Journal of India, volume 16, page 335-336, 2003
                         Harvard School of Dental Medicine Research Bulletin, November, 2003

Razzaque MS. 2004. Fibrogenesis: Cellular and Molecular Basis (ISBN:0-306-47861-7); SPRINGER, USA.

     Book reviews/introductions are published in:
                         Kidney International, volume 67, page 2085, 2005
                         Harvard School of Dental Medicine Research Bulletin, May/June, 2005
                        Focus (http://focus.hms.harvard.edu), page 7, June 10, 2005

Razzaque MS, Taguchi T. 2005. Cellular Stress Responses in Renal Diseases; Contribution to Nephrology, Volume 148 (ISBN:3-8055-7858-X), KARGER PUBLISHERS, Basel, Switzerland.

     Book reviews/introductions are published in:
                         Dyalysis and Transplantation, September, 2005
                         Focus (http://focus.hms.harvard.edu), page 6, February 10, 2006
                         Histopathology, Volume 48, page 604, 2006

Book Chapters

Razzaque MS, Azouz A, Shinagawa T, Taguchi T. Factors regulating the progression of hypertensive nephrosclerosis. Contribution to Nephrology 2003; 139:173-186.

Razzaque MS, Taguchi T. Factors that influence and contribute to the regulation of fibrosis. Contribution to Nephrology 2003; 139: 1-11.

Inan MS, Razzaque MS, Taguchi T. Pathological significance of renal expression of NF-kB. Contribution to Nephrology 2003; 139:90-101.

Razzaque MS, El-Hallak M, Azouz A, Taguchi T. Tissue scarring: lesions from wound healing, in Fibrogenesis: Cellular and Molecular Basis 2004; 1-8.

Wada T, Razzaque MS, Matsushima K, Taguchi T, Yokoyama H. Pathological significance of renal expression of proinflammatory molecules, in Fibrogenesis: Cellular and Molecular Basis 2004; 9-26.

Ahmed W, Razzaque MS, Taguchi T. Can manipulation of apoptotic cell death benefit tissue scarring?, in Fibrogenesis: Cellular and Molecular Basis 2004, 162-179.

Razzaque MS, Le VT, Taguchi T. Heat shock protein 47 and renal fibrogenesis. Contribution to Nephrology 2005; 148:57-69.

Abid MR, Razzaque MS, Taguchi T. Oxidative stress in renal pathophysiology. Contribution to Nephrology 2005, 148:135-153.

Razzaque MS, Taguchi T. Involvement of stress proteins in renal diseases. Contribution to Nephrology 2005; 148:1-7.

Taguchi T, Nazneen A, Abid MR, Razzaque MS. Cisplatin-associated nephrotoxicity and pathological events. Contribution to Nephrology 2005; 148:107-121.

Original Articles (partial list, *:corresponding author)

1. Razzaque MS, Koji T, Taguchi T*, Harada T, Nakane PK. In situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathy.   Journal of Pathology 1994; 174:131-138.

2. Razzaque MS*, Taguchi T. Expression of type III collagen mRNA in renal biopsy specimens of patients with idiopathic membranous glomerulonephritis. Journal of Clinical Pathology (Molecular Pathology) 1996; 49:M40-M42.

3. Razzaque MS*, Taguchi T. Collagen-binding heat shock protein (HSP) 47 expression in anti-thymocyte serum (ATS)-induced glomerulonephritis.   Journal of Pathology 1997; 183:24-29.

4. Razzaque MS*, Nazneen A, Taguchi T. Immunolocalization of collagen and collagen-binding heat shock protein 47 in fibrotic lung diseases. Modern Pathology 1998; 11:1183-1188.

5. Razzaque MS*, Hossain MA, Kohno S, Taguchi T.    Bleomycin-induced pulmonary fibrosis in rat is associated with increased expression of collagen-binding heat shock protein (HSP) 47.   Virchows Archive 1998; 432:455-460.

6. Horita Y, Miyazaki M, Koji T, Kobyashi N, Shibuya M, Razzaque MS, Cheng M, Ozono Y, Khono S, Taguchi T*. Expression of vascular endothelial growth factor and its receptors in rat with protein-overload nephrosis. Nephrology Dialysis and Transplantation 1998; 13:2519-2528.

7. Razzaque MS*, Shimokawa I, Nazneen A, Higami Y, Taguchi T. Age-related nephropathy in the Fischer 344 rat is associated with overexpression of collagens and collagen-binding heat shock protein 47.   Cell and Tissue Research 1998; 293:471-478.

8. Rashid MA, Akita S*, Razzaque MS, Yoshimoto H, Ishihara H, Fuji T, Tanaka K, Taguchi T. Coadministration of basic fibroblast growth factor and sucrose octasulfate (sucralfate) facilitate the rat dorsal flap survival and viability. Plastic and Reconstructive Surgery 1999; 103:941-948.

9. Razzaque MS, Koji T, Kumatori A, Taguchi T*. Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with activation of Fas/Fas ligand system. Histochemistry and Cell Biology 1999; 111:359-365.

10. Naito T, Razzaque MS, Nazneen A, Liu D, Nihei H, Koji T, Taguchi T*. Renal expression of ets-1 protooncogene during progression of rat crescentic glomerulonephritis. Journal of American Society of Nephrology 2000; 11:2243-2255.

11. Hossain MA, Maesaki S, Razzaque MS, Tomono K, Taguchi T, Kohno S*.   Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B.   Journal of Antimicrobial Chemotherapy 2000; 46:263-268.

12. Colon JE, Bhol KC, Razzaque MS, Ahmed AR*. In vitro organ culture model for mucous membrane pemphigoid. Clinical Immunology 2001; 98:229-234.

13. Kumari S, Bhol KC, Simmons RK, Razzaque MS, Letko E, Foster CS, Ahmed AR*. Identification of ocular cicatricial pemphigoid antibody binding epitope in human b4 integrin. Investigative Ophthalmology and Visual Science 2001; 42:379-385.

14. Zhang M-Y, Huang N-N, Clawson G, Osmani SA, Pan W, Xin P, Razzaque MS, Miller BA*. The human homolog of the fungal nuclear migration gene NUDC is involved in cell proliferation and mitotic spindle formation. Experimental Cell Research 2002; 273:73-84.

15. Ahsan N*, Holman MJ, Jarowenko MV, Razzaque MS, Yang HC. Limited dose monoclonal IL-2R antibody induction protocol after primary kidney transplantation. American Journal of Transplantation 2002; 2:568-573.

16. Razzaque MS, Foster CS, Ahmed AR*. Role of enhanced expression of m-CSF in conjunctiva affected by cicatricial pemphigoid. Investigative Ophthalmology and Visual Science 2002; 43:2977-83.

17. Razzaque MS, Foster CS, Ahmed AR*. Role of collagen-binding heat shock protein 47 and transforming growth factor beta 1 in conjunctival scarring in ocular cicatritial pemphigoid. Investigative Ophthalmology and Visual Science 2003; 44:1616-1621.

18. Razzaque MS, Foster CS, Ahmed AR*. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Investigative Ophthalmology and Visual Science 2003; 44:1998-2003.

19. Razzaque MS, Ahmed B, Foster CS, Ahmed AR*. IL-4 induces m-CSF, HSP47 and collagen by conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. Investigative Ophthalmology and Visual Science 2003; 44: 3417-3423.

20. Razzaque MS, Foster CS, Ahmed AR*. Role of macrophage migration inhibitory factor in conjunctival pathology in cicatricial pemphigoid. Investigative Ophthalmology and Visual Science 2004; 45: 1174-1181.

21. Razzaque MS, Soegiarto DW, Long F, Lanske B*. Conditional deletion of Indian hedgehog from collagen type 2 alpha1-expressing cells results in abnormal endochondral bone formation. Journal of Pathology 2005; 453-461.

22. Sitara D, Razzaque MS, St-Arnaud R, Huang W, Taguchi T, Erben RG, Lanske B*. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23 null mice. American Journal of Pathology 2006;169:2161-2170.

23. Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B*. Premature ageing-like phenotype in fibroblast growth factor-23 null mice is a vitamin-D mediated process. FASEB J 2006; 20:720-722.

24. Zha Y, Le VT, Higami Y, Shimokawa I, Taguchi T, Razzaque MS*. Life-long supression of growth hormone-insulin-like growth factor-1 activity in the genetically altered rats could prevent age-related renal damage. Endocrinology 2006;147:5690-5698.

25. Ogawa Y*, Razzaque MS, Kameyama K, Hasegawa G, Shimmura S, Kawai M, Okamoto S, Ikeda Y, Tsubota K, Kawakami Y, Kuwana M. Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland disese in patients with cGVHD. Investigative Ophthalmology and Visual Science 2007; 48:1079-1086.

Proceedings of Meetings

1. Razzaque MS, Taguchi T*. Possible role of glomerular epithelial cell-derived HSP47 in experimental lipid nephropathy. Kidney International 1999; 56:S256-S259.

Editorials, Reviews, Comments and Hypothesis

1. Razzaque MS*, Taguchi T. The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases. Histology and Histopathology 1999; 14:1199-1212.

2. Razzaque MS*, Ahsan N, Taguchi T. Heat shock protein 47 in renal scarring. Nephron 2000; 86:339-341.

3. Razzaque MS*, Naito T, Taguchi T. Proto-oncogene ets-1 and the kidney. Nephron 2001; 89:1-4.

4. Razzaque MS, Foster CS, Ahmed AR*. Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid. Histology and Histopathology 2001; 16: 1203-1212.

5. Razzaque MS*, Hossain MA, Ahsan N, Taguchi T. Lipid formulations of polyene anti-fungal drugs and attenuation of associated nephrotoxicity. Nephron 2001; 89:251-254.

6. Razzaque MS, Taguchi T*. Cellular and molecular events leading to renal tubulointerstitial fibrosis. Medical Electron Microscopy 2002; 35:68-80.

7. Razzaque MS, Ahsan N, Taguchi T*. Role of apoptosis in fibrogenesis. Nephron 2002; 90:365-372.

8. Razzaque MS*, Taguchi T. Pulmonary fibrosis: cellular and molecular events. Pathology International 2003; 53:133-145.

9. Razzaque MS*, Taguchi T. Renal expression of NF-kB: Possible implications in disease progression. Nephrology and Hypertension 2004; 10:1-7.

10. Azouz A, Razzaque MS*, El-Hallak M, Taguchi T. Immunoinflammatory responses and fibrogenesis. Medical Electron Microscopy 2004; 37:141-148.

11. Razzaque MS*, St-Arnaud R, Taguchi T, Lanske B. Fgf-23, vitamin D and calcification:The unholy traid. Nephrology Dialysis and Transplantation 2005; 20:2032-2035.

12. Razzaque MS*, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf-23 and klotho mutant mice. Trends in Molecular Medicine 2006; 12:298-305.

13. Lanske B*, Razzaque MS*. Premature aging in klotho deficient mice: cause or consequence?. Ageing Research Review 2007; 6:73-79.

14. Razzaque MS*, Lanske B. The emerging role of FGF23-Klotho axis in renal regulation of phosphate homeostasis. Journal of Endocrinology 2007; 194: in press.

15. Taguchi T, Razzaque MS*. Collagen-specific molecular chaperone HSP47: is there a role in fibrosis? Trends in Molecular Medicine 2007; 13:45-53.

Clinical Research and Preliminary Communications (partial list)

1. Razzaque MS*, Taguchi T. Similarities of intraglomerular collagen synthesis in IgA nephropathy and diabetic glomerulosclerosis. Modern Pathology 1994; 7:891.

2. Razzaque MS*, Harada T, Taguchi T. Long-term follow-up of idiopathic membranous glomerulonephritis with its natural course. Clinical Nephrology 1995; 44:137-139.

3. Razzaque MS*, Taguchi T. Increased expression of type III and type IV collagen in diabetic nephropathy. Diabetologia 1995; 38:632-633.

4. Razzaque MS*, Koji T, Harada T, Nakane PK, Taguchi T. Primary focal segmental glomerulosclerosis is associated with increased intraglomerular type IV collagen synthesis.
Clinica Chimica Acta 1995; 235:121-124.

5. Razzaque MS*, Harada T, Taguchi T. Distribution and cellular origin of type III, type IV and type VI collagens in tubulointerstitial damage in various renal diseases. Clinical Nephrology 1996; 46:213-215.

6. Razzaque MS*, Kumatori A, Harada T, Taguchi T. Coexpression of collagens and collagen-binding heat shock protein 47 in human IgA nephropathy and diabetic nephropathy. Nephron 1998; 80:434-443.

7. Razzaque MS*, Koji T, Harada T, Taguchi T. Localization in situ of type VI collagen protein and its mRNA in mesangial proliferative glomerulonephritis using renal biopsy sections. Histochemistry and Cell Biology 1999; 111:1-6.

8. Razzaque MS*, Yamaguchi K, Taguchi T. An unusual case of dense deposit disease with nodular sclerotic lesions of the glomeruli. Clinical Nephrology 1999; 51:326-328.

9. Razzaque MS*, Taguchi T. Localisation of HSP47 in cisplatin-treated kidney: possible role in tubulointerstitial damage. Clinical and Experimental Nephrology 1999; 3:123-132.

10. Razzaque MS*, Shimokawa I, Koji T, Higami Y, Taguchi T. Life-long caloric restriction supresses age-associated Fas expression in the Fischer 344 rat is kidney.   Molecular Cell Biology Research Communication 1999; 1:82-85.

11. Razzaque MS*, Taguchi T. Evidence of increased expression of synaptic basal lamina protein agrin in glomerulosclerosis. Kidney International 2000; 57:1774-1775.

12. Liu D, Razzaque MS, Cheng M, Taguchi T*. The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats. Histochemical Journal 2001, 33:621-628.

13. Razzaque MS, Ahmed AR*. Collagen, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis. Cytokine 2002; 17:311-316.

14. Liu D, Razzaque MS, Nazneen A, Naito T, Taguchi T*. Role of heat shock protein 47 on tubulointerstitium in experimental radiation nephropathy.   Pathology International 2002; 52:340-347.

15. Nazneen A, Razzaque MS, Liu D, Taguchi T*. Possible role of Ets-1 and MMP-1 in matrix remodeling in experimental cisplatin nephropathy.   Medical Electron Microscopy 2002; 35:242-247.

16. Ahsan N*, Holman MJ, Razzaque MS, Yang HC. Induction of single intraoperative dose of OKT-3: a novel approach to reduce early allograft rejection. Graft 2002; 5:344-351.

17. Razzaque MS, Kumari S, Foster CS, Ahmed AR*. Expression profiles of collagens, HSP47, TGF-b1, MMPs and TIMPs in epidermolysis bullosa acquisita. Cytokine 2003; 21:207-213.

18. Ohba K*, Matsuo M, Noguchi M, Nishikido M, Koga S, Kanetake H, Nazneen A, Liu D, Razzaque MS, Taguchi T. Clinicopathological study of vesicoureteral reflux (VUR)-associated pyelonephritis in renal transplantation.   Clinical Transplantation 2004; 18:34-38 (Suppl. 11).

19. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H, Lanske B*. Homozygous ablation of fibroblast growth factor-23 (Fgf-23) results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biology 2004; 23: 421-432.

20. Ohba K, Miyata Y, Noguchi M, Koga S, Nishikido M, Kanetake H, Nazneen A, Razzaque MS, Taguchi T*. Interstitial expression of heat shock protein 47 correlates with capillary deposition of complement split product C4d in chronic allograft nephropathy. Clinical Transplantation 2005; 19:810-816.

Symposium and Invited Lectures

1. M. S. Razzaque. Tubulointerstitial damage in human and experimental renal diseases: histopathological analysis. 28th West Japan Congress of Nephrology, Nara, JAPAN, 1998. Japanese Journal of Nephrology 40(6):391, 1998.

2. M. S. Razzaque, A. Nazneen, D. G. Liu, T. Naito, T. Harada, T. Taguchi. Role of glomerular epithelial cell-derived HSP47 in early glomerular injury in rats with dietary induced hypercholesterolemia. International Symposium on Lipids and Renal Diseases, Wakayama, JAPAN, October 1998.

3. M. S. Razzaque, N. Ohnishi, M. Yamamoto, D. Liu, A. Nazneen, M. Cheng, Y. Ozono, T. Harada, T. Taguchi. Human and experimental renal sclerosis/fibrosis correlates with increased expression of heat shock protein 47. 2nd International Forum-The Frontiers of Nephrology, Tokyo, JAPAN, May 1998.

4. M. S. Razzaque, T. Taguchi. Renal scarring: new morphological approaches to solve an old problem. 33rd Annual Meeting of Japanese Society for Clinical Electron Microscopy, Nagasaki, JAPAN, September 2001.

5. M. S. Razzaque, C. S. Foster, A. R. Ahmed. Molecular mechanisms of conjunctival scarring in ocular cicatricial pemohigoid. 23rd Biennial Corneal Research Conference, Boston, USA, October 2003.

6. M. S. Razzaque. Stress responses and fibrogenesis. 35th West Japan Congress of Nephrology, Nagasaki, JAPAN. Japanese Journal of Nephrology 2005.

7. M. S. Razzaque. FGF23 and Skeletogenesis. Invited seminar, Institute for Viral Research, Kyoto University, Kyoto, JAPAN, 2005.

Scientific Meetings and Abstracts

Presented in over 95 International, Japanese and American scientific society meetings, and published as abstracts.

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