REFERENCES FOR FURTHER READING

• Arakawa T, Chong DK, Merritt JL, et al. (1997). Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Res; 6: 403-413.
• Arakawa T, Yu J, Chong DK, et al. (1998). A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat Biotechnol; 16: 934-938.
• Arakawa T, Yu J, Langridge WH. (2001). Synthesis of a cholera toxin B subunit-rotavirus NSP4 fusion protein in potato. Plant cell Rep; 20: 343-348.
• Arntzen, CJ and DD Kirk. (2000). Vaccination. McGraw-Hill Yearbook of Science & Technology. pp. 434-435.
• Arntzen, CJ and HS Mason. (1997). Oral vaccine production in the edible tissues of transgenic plants. IN: New Generation Vaccines (2nd edition) (MM Levine, GC Woodrow, JB Kaper, GS Cobon, eds) Marcel Dekker, Inc., New York, NY. pp. 263-277.
• Arntzen, CJ, HS Mason, JJ Shi, TA Haq, MK Estes and JD Clements. (1994). Production of candidate oral vaccines in edible tissues of transgenic plants. IN : Vaccines '94, Modern Approaches to New Vaccines Including Prevention of AIDS. Cold Spring Harbor Laboratory Press, N.Y. pp. 339-348.
• Arntzen, CJ. (1996). Edible vaccines produced in transgenic plants. IN : The Jordan Report. Natl Inst Allergy Infect Dis, Div Microbiol Infect Dis, NIH, Bethesda, MD, pp. 43-48.
• Arntzen, CJ. (1997). Edible Vaccines. IN : Public Health Rep., J. US Public Health Service, Boston, MA, 112: 191-197.
• Arntzen, CJ. (1997). High-tech herbal medicine: Plant-based vaccines. Nat Biotechnology 15: 221-222.
• Arntzen, CJ. (1998). Pharmaceutical foodstuffs-Oral immunization with transgenic plants. Nature Medicine Vaccine Supplement, 4: 502-503.
• Backstrom M, Holmgren J, Schodel F, et al. (1995). Characterization of an internal permissive site in the cholera toxin B-subunit and insertion of epitopes from human immunodeficiency virus-1, hepatitis B virus and enterotoxigenic Escherichia coli. Gene; 165: 163-71.
• Beetham, PR, PB Kipp, XL Sawycky, CJ Arntzen and GD May. (1999). A tool for functional plant genomics: Chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations. Proc Natl Acad Sci USA 96: 8774-8778.
• Biemans, R., Thines, D, Petre-Parent, B., DeWilde, M., Rutgers, T. & Cabezon, T. (1992) DNA Cell Biol. 11: 621-626.
• Bowman CC, Clements JD. (2001). Differential biological and adjuvant activities of cholera toxin and Escherichia coli heat-labile enterotoxin hybrids. Infect Immun; 69: 1528-1535.
• Brennan FR, Bellaby T, Helliwell SM, et al. (1999). Chimeric plant virus particles administered nasally or orally induce systemic and mucosal immune responses in mice. J Virol; 73: 930-938.
• Brennan FR, Jones TD, Gilleland LB, et al. (1999). Pscudomonas acruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus. Microbiology. 145: 211-220.
• Carrillo C, Wigdorovitz A, Oliveros JC, Zamorano PI, Sadir AM, Gomez N, Salinas J, Escribano JM, Borca MV (1998). J Virol 72: 1688-1690.
• Carter JEIII, Langridge HR. (2002). Plant-based vaccines for protection against infectious and autoimmune diseases. Crit Rev Plant Sci; 21: 93-109.
• Clements, J.D., Hartzog, N.M. & Lyon, F.L. (1988) Vaccine 6: 269-277
• Curtiss RI, Cardineau CA. (1990). Oral immunisation by transgenic plants, World Patent Application WO 90/02484.
• Dalsgaard K, Uttenthal A, Jones TD, et al. (1997). Plant derived vaccines protects target animals against a viral disease. Nat Biotechnol; 15: 248-252.
• Daniel Chargelegne, Patrica Obregon and Pascal M.W. (1999). Drake HMS Beagle, Issue 112.
• Daniell H, Khan MS, Allison L. (2002). Milestones in chloroplast genetic engineering: an environmental friendly era in biotechnology. TRENDS Plant Sci; 7: 84-91.
• Daniell H, Muthukumar B, Lee SB. (2001). Marker free transgenic plants: engineering the chloroplast genome without the use of antibiotic resistance genes. Curr Genet; 39: 109-110.
• Daniell H, Streatfield J, Wycoff K. (2001). Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. TRENDS Plant Sci; 6: 6-219.
• de Quadros, C. (2000) EPI Newsletter: Expanded Program on Immunization in the Americas, Vol. XXII, No. 1, p. 8.
• DeCosa B, Moar W, Lee SB, Miller M, Daniell H. (2001). Over expression of the BtCry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nature Biotechnol; 4: 71-74.
• Dertzbaugh MT, Elson Co. (1993). Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines. Infect Immun; 61: 48-55.
• Dertzbaugh MT, Elson CO. (1993). Reduction in oral immunogenicity of cholera toxin B subunit by N-terminal peptide addition. Infect Immun; 61: 384-390.
• Di Tommaso, A., Saletti, G., Pizza, M., Rappuoli, R., Dougan, G., Abrignani, S., Douce, G. & De Magistris, M.T. (1996) Infect. Immun. 64: 974-979.
• Dickinson, B.L. & Clements, J.D. (1995) Infect. Immun. 63: 1617-1623.
• Dixon, RA and CJ Arntzen. (1997). Transgenic plant technology entering the era of metabolic engineering. TIBTECH, 15: 441-444.
• Fan E, Merritt EA, Zhang Z, et al. (2001). Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallog Biolog Crystallog;  57: 201-212.
• Firat H, Garcia-Pons F, Tourdot S, et al. (1999). H-2 Class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies. Eur J Immunol;  29: 3112-3121.
• Fitchen J, Beachy RN, Hein MB. (1995). Plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response. Vaccine;  13: 1051-1057.
• Francis, D.P., Hadler, S.C., Thompson, S.E., Maynard, J.E., Ostrow, D.G., Altman, N., Braff, E.H., O’Malley, P. M., Hawkins, D., Judson, F.N., et al. (1982) Ann. Int. Med. 97: 362-366.
• Gonzalez RA, Sanchez J, Holmgren J, et al. (1993). Immunological characterization of a rotavirus-neutralizing epitope fused to the cholera toxin B subunit. Gene; 133: 227-232.
• Hadler, S.C., Francis, D.P., Maynard, J.E., Thompson, S.E., Judson, F.N., Echenberg, D.F., Ostrow, D.G., O’Malley, P.M., Penley, K.A., Altman, N.L., et al. (1986) N. Engl. J. Med. 315: 209-214.
• Haq, TA, HS Mason, JD Clements and CJ Arntzen. (1995) Oral immunization with a recombinant antigen produced in transgenic plants. bacterial protein in transgenic plants. Science; 268: 714-716.
• Hefferon, KL, HS Mason and CJ Arntzen. In Press. The use of transgenic plants for oral vaccination. IN: Focus on Biotechnology.
• Hiuary E. Sussman. Bio Med Net News and Comment, 18 April 2003 17:00 GMT. "Spinach makes a safer Anthrax vaccine".
• Holmgren, J., Lycke, N. & Czerkinsky, C. (1993) Vaccine 11: 1179-1184.
• Jakobsen, H., Schulz, D., Pizza, M., Rappuoli, R. & Jonsdottir, I. (1999) Infect. Immun. 67:  5892-5897.
• Kann, M. & Gerlich, W. (1998) in Viral Hepatitis, eds. Zuckerman, J.N., Harrison, T.J. & Zuckerman, A.J. (Churchill Livingstone, London), pp. 77-105.
• Kapusta, J.; Modelska, A.; Figlerowicz, M.; Pniewski, T.; Letellier, M.; Lisowa, O.; Yusibov, V.; Koprowski, H.; Plucienniczak, A.; Legocki, A.B. A plant-derived edible vaccine against hepatitis B virus. FASEB Journal [FASEB J.], vol. 13, no. 13, p. 1796-1799, Oct 1999.
• Kirk, DD, HS Mason and CJ Arntzen. (1999). Transgenic plants as delivery systems - A proof of concept. IN: Molecular Intervention in Disease, Proceedings of the Fifth Annual Ranbaxy Science Foundation.  pp.  51-55.
• Kong Q, Richter L, Thanavala Y, Yu FY, Arntzen CJ, Mason HS, et al. (2001). Oral immunisation with hepatitis B surface antigen expressed in transgenic plants. PNAS; 98: 11539-11544.
• Koprowski H, Yusibov V. (2001). The green revolution: plants as heterologous expression vectors. Vaccine; 19: 2735-2741.
• Kuroda H, Maliga P. (2001). Sequence downstream of the translation initiation codon are important determinants of translation efficiency in chloroplasts. Plant Physiol; 125: 430-436.
• Liljeqvist S, Stahl S, Andreoni C, et al. (1997). Fusions to the cholera toxin B subunit: influence on pentamerization and GM1 binding. J Immunol Methods;  210: 125-135.
• Livingston PO. (1998). The case of melanoma vaccines that induce antibodies. In: Kirkwood JM, editor. Molecular diagnosis, prevention and treatment of melanoma. Marcel Dekker; p. 139-157.
• Ma JKC. (2001). Genes, greens and vaccines. Nature Biotechnol; 18: 1141-1142.
• Ma S, Jevnikar AM. (1999). Autoantigens produced in plants for oral tolerance therapy of autoimmune diseases. In: Shahidi et al., editors. Chemicals via higher plant biotechnology. New York: Kluwer Academic Publishers/Plenum Publishers; p. 179-194.
• Maliga P. (2002). Engineering the plastid genome of higher plants. Curr Opin Plant Biol;  5: 164-172.
• Mason HS, Ball JM, Shi JJ, et al. (1996). Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA; 93:  5335-5340.
• Mason HS, Haq TA, Clements JD, Arntzen, CJ. (1998). Vaccin 16: 1336-1343.
• Mason HS, Haq TA, Clements JD, et al. (1998). Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine; 16: 1336-1343.
• Mason HS, Lam DM, Arntzen CJ. (1992). Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA; 89: 11745-11749.
• Mason, HS and CJ Arntzen. (1998). Edible vaccines - the future for paediatric vaccines delivery ? Vaccines: Children & Practice, 1: 13-15.
• Mason, HS, CO Tacket, LJ Richter and CJ Arntzen. (1998). Subunit vaccines produced and delivered in transgenic plants as “edible vaccines”. Res Immunol 149: 71-74.
• Mason, HS, JM Ball, J-J Shi, X Jiang, MK Estes and CJ Arntzen. (1996). Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA 93: 5335-5534.
• Mason, HS, TA Haq, JD Clements and CJ Arntzen. (1998). Edible vaccine protects mice against E. coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT- B gene. Vaccine, 16: 1336-1343.
• Mason, HS; Arntzen, CJ. (1995). Transgenic plants as vaccine production systems. Trends in Biotechnology [TRENDS BIOTECHNOL.], vol. 13, no. 9, pp. 388-392.
• May, GD, R Afza, HS Mason, A Wiecko, FJ Novak and CJ Arntzen. (1995). Generation of transgenic banana (Musa Acuminata) plants via Agrobacterium- mediated transformation. Bio/Technology, 13: 486-492.
• McGarvey PB, Hammond J, Dienelt MM, et al. (1995). Expression of the rabies virus glycoprotein in transgenic tomatoes. Biotechnology; 13: 1484-1487.
• Millar DG, Hirst TR, Snider DP. (2001). Escherichia coli heat labile enterotoxin B subunit is a more potent mucosal adjuvant than its closely related homologue, the B subunit of cholera toxin. Infect Immun;  69: 3476-3482.
• Milstien J, Dellepiane N, Lambert S. (2002). Vaccine quality - can a single standard be defined ? Vaccine;  20: 1000-1003.
• Mor, TS and CJ Arntzen. Pharmaceutical foodstuffs : oral immunization with transgenic plants. Proc. IXth International Congress of International Assoc. of Plant Tissue Culture and Biotechnology. pp. 17-20.
• Nedrud, J. & Sigmund, N. (1991) Regional Immunol. 3: 217-222.
• O' Dowd AM, Botting CH, Precious B, et al. (1999). Novel modifications to the C-terminus of LTB that facilitate site-directed chemical coupling of antigens and the development of LTB as a carrier for mucosal vaccines. Vaccine;  17: 1442-1453.
• Palmer, KE, CJ Arntzen and G Lomonossoff. (1999). Antigen Delivery Systems - Transgenic Plants and Recombinant Plant Viruses. IN: Mucosal Immunology (2nd edition) (PL Ogra, J Mestecky, ME Lamm, W Strober, J R McGhee, J Bienenstock, eds), Ch. 49:793-807. Academic Press, San Deigo, CA.
• Patzer, E.J., Nakamura, G.R., Simonsen, C.C., Levinson, A.D. & Brands, R. (1986) J. Virol. 58:  884-892.
• Pillai D, Dixit A, Alok D, et al. (1996). Translational fusion of heat labile enterotoxin chain B and beta-subunit of human chorionic gonadotropin: periplasmic expression in Escherichia coli and its immunogenicity. FEBS Lett; 387: 23-26.
• Puchta H. (2000). Removing selectable marker genes: taking the shortcut. TRENDS Plant Sci;  5: 273-274.
• Qingxian Kong, Liz Richter, Yu Fang Yand, Charles J. Arntzen. Hugh S. Mason, and Yasmin Thanavala. (Sept. 2001). Proc. Natl. Acad. Sci. USA, Vol. 98, Issue 20: 11539-11544.
• Richter, L, HS Mason and CJ Arntzen. (1996). Production of oral vaccines for diarrheal disease in transgenic plants. J Travel Med 3: 52-56.
• Richter, L.J., Thanavala, Y., Arntzen, C.J. & Mason, H.S. (2000) Nat. Biotechnol. 18: 1167-1171.
• Richter, L; Kipp, PB. (1999). Current Topics in Microbiology and Immunology [Curr. Top. Microbiol. Immunol.], vol. 240:  159-176.
• Sitrin, R.D. & Wampler, D.E. (1992) in Hepatitis B Vaccines in Clinical Practice, ed. Ellis, R.W. (Dekker, New York). pp. 83-102.
• Sixma TK, Pronk SE, Kalk KH, et al. (1991). Crystal structure of a cholera toxin-related heat-labile exterotoxin from E. coli. Nature; 351: 371-377 (see comments).
• Spangler BD. (1992). Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev; 56: 622-642.
• Suh, S.G., Stiekma, W.J. & Hannapel, D.J. (1991) Planta (Heidelberg) 184: 423-430.
• Szmuness, W., Stevens, C.E., Harley, E.J., Zang, E.A., Alter, H.J., Taylor, P.E., DeVera, A., Chen, G.T. & Kellner, A. (1982) N. Engl. J. Med. 307, 1481-1486.
• Szmuness, W., Stevens, C.E., Harley, E.J., Zang, E.A., Oleszko, W.R., William, D.C., Sadovsky, R., Morrison, J.M. & Kellner, A. (1980) N. Engl. J. Med. 303: 833-841.
• Tacket CO, Mason HS, Losonsky G, et al. (1998). Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med; 4: 607-609.
• Tacket CO, Reid RH, Boedcker EC, et al. (1994). Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres. Vaccine; 12: 1270-1274.
• Tacket, C.O. & Mason, H.S. (1999) Microbes Infect. 1: 1-7.
• Tacket, C.O., Mason, H.S., Losonsky, G., Clements, J.D., Levine, M.M. & Arntzen, C.J. (1998) Nat. Med. 4: 607-609.
• Tacket, C.O., Mason, H.S., Losonsky, G., Estes, M.K., Levine, M.M. & Arntzen, C.J. (2000) J. Infect. Dis. 182: 302-305.
• Tacket, CO, HS Mason, G Losonsky, JD Clements, MM Levine and CJ Arntzen, (1998). Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nature Medicine, 4: 607-609.
• Tacket, CO, HS Mason, G Losonsky, MK Estes, MM Levine and CJ Arntzen. (2000). Human immune responses to a Novel Norwalk virus vaccine delivered in transenic potatoes. The Journal of Infectious Disease. 182: 302-305.
• Thanavala, Y., Y-F Yang, P Lyons, HS Mason and CJ Arntzen, (1995). Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc. Natl. Acad. Sci. USA 92: 3358-3361.
• Vaccine (March, 2001). Volume 19, Issues 17-19, Pages 2688-2691.
• Walmsley AM, Arntzen, CJ. (2000). Plants for delivery of edible vaccines. Curr Opin Biotechnol; 11: 126-129.
• Walmsley, A.M., Mason, H.S. & Arntzen, C.J. (1999) Mucosal Immunol. Update 7, 12-14.
• Walmsley, AM and CJ Arntzen. (2000). Plants for delivery of edible vaccines. Current Opinion in Biotechnolog. 2000. 11: 126-129.
• Walmsley, AM, HS Mason and CJ Arntzen. (1999). The development of transgenic plants as edible vaccines. Mucosal Immunology Update. 7: 12-14.
• Wong, SY, KS Ho, HS Mason and CJ Arntzen. (1998). Edible Vaccines. Science & Medicine, 5: 36-45.
• Yu J, Langridge WH. (2001). A plant based multicomponent vaccine protects mice from enteric diseases. Nat Biotechnol; 19:  548-552.
• Yusibov V, Modelska A, Steplewski K, Agadjanyan M, Weiner D, Hooper DC, Koprowski H. (1997). Proc. National Acad. Sci. USA, Vol. 94: 5784-5788.
• Yusibov V, Modelska A, Steplewski K, et al. (1997). Antigens produced in plants by infection with chimeric plant viruses immunize against rabies and HIV-. Proc Natl Acad Sci USA; 94: 5784-5788.
• Zeitlin, L; Olmsted, SS; Moench, TR; Co, MS; Martinell, BJ; Paradkar, VM; Russell, DR; Queen, C; Cone, RA; Whaley, KJ. (Dec., 1998) Nature Biotechnology [Nat. Biotechnol.], vol. 16, no. 13: 1361-1364.
• Zhang H, Zhang S, Cheung NK, Ragupathi G, Livingston PO. (1998). Antibodies can eradicate cancer micrometastasis. Cancer Res; 58:  2844-2849.
• Zhang T, Li E, Stanley SLJ. (1995). Oral immunization with the dodecapeptide repeat of the serine-rich Entamoeba histolytica protein (SREHP) fused to the cholera toxin B subunit induces a mucosal and systemic anti-SREHP antibody response. Infect Immun; 63:  1349-1355.