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PATH 701 Cellular and Molecular Pathology 3(2-1)
Learning
Objectives:
Students will learn the molecular mechanisms involved in
cellular pathology, the role of genetics in pathology, and
the principles and practices of histochemistry and
immunohistochemistry in pathology.
Theory
Molecular mechanisms in adaptation; Biochemical and
molecular mechanics of cell injury; Ultrastructural changes
in cell injury; The genetics of cell death; Inflammation:
Early check points during
inflammation; Cells and molecular players in sterile and
non-sterile inflammation, Inflammatory reflex, inflamosome,
Molecular events in phagocytosis and killing of pathogens;
Untoward effects of
inflammation; Molecular PAMS, Role of Pattern Recognition
Receptors , Molecular cross-talk during healing and repair;
The ubiquitin-proteasome pathway: On protein death and cell
life, SUMO proteins ; Chaperons and metalochaperons, their
role in cell pathology; Sphingolipids and microbial
pathogenesis; Molecular beacons; Stem cells and tissue
repair.
Practical
Proficiency to recognize and describe gross and histological
changes in tissues; Use of special and H & E stains in cell
pathology; Markers of tissue injury; In situ hybridization;
Karyotype analysis; Trans well chemotaxis ; Electron
microscopic examination of sub-cellular changes;
Histochemical and immunohistochemical techniques in cell
pathology.
Suggested
Readings:
1. Electronics ources – digital libraries, books , journals
, etc.
2. Majno, G. and I. Joris . 2004. Cells , Tissues, and
Disease: Principles of General Pathology. 2nd Ed. Oxford
University Press, New York, USA.
3. McGavin, D.M . and J.F . Zachary. 2007. Pathologic Bas is
of Veterinary Disease. 4th Ed. Mos by, St. Louis , MO, USA
4. Slauson, D.O. and B.J. Cooper. 2002. Mechanisms of
Disease. 3r d Ed. Williams & Wilkins, London, UK
5. Tubbs , R.R. and M.H. Stoler. 20 0 8 . Cell and Tissue
Based Molecular Pathology. Churchill Livings tone, New York,
USA. |