April O'Neil and Elisa Maza. Both having their adventures in the city of New York, and both were the touchstone of humanity in their respective animated series.
But every once in a while, that touchstone changed. In Teenage Mutant Ninja Turtles, April was mutated into a cat person, a fish person, and an insect person. In Gargoyles, Elisa was magically transformed into a statue and into a gargoyle herself.
And yet, neither one became a centaur -- until now, when a mysterious figure had their paths cross with the Statue of Hippodamia.
Wonder Woman
Supergirl and Batgirl
Supergirl and Lois Lane
Batgirl and Hawkgirl
April O'Neil and Elisa Maza
Ranma Saotome