Founded June 1, 1945, Mu Iota was incorporated to strengthen and preserve the Omega tradition and ideals that the undergraduate chapter at Ohio State, Iota Psi, had already established. Four Brothers from Beta Chapter at Lincoln University in Pennsylvania took it upon themselves to establish a forum for Omega Men in the Columbus area to fellowship. Once Brothers Jack White, Allen Wright, George Carter and Brother Peters founded Mu Iota, at least 30 men in the Columbus area joined them in their quest to uplift Omega. By 1948, the chapter had been so successful that the National Conclave was held in Columbus that same year.

Many of the community programs that these founding members began are still in place today. Mu Iota sponsors/participates in the following activities yearly:

In addition to these programs, Mu Iota participates in other activities that help build the communities in which the Men of Mu Iota belong.