To Welcome
OVARIAN HORMONE THERAPY
General - risks, definition of NHRT Which OHT?  Deciding on it  Getting off it  "Natural" hormones Long term considerations
  natural progesterone 
  natural estrogens
  definition of NHRT
Personal posts about "natural" progesterone
Authors retain copyright and responsibility for content
Natural progesterone use for a woman with breast cancer
The controversy about natural progesterone creme
"It does seem as if [NP cream] is not all the hoo-ha it's supposed to be."
"Estrogen dominance"
Natural progesterone *does* have side effects
     
    Well, my problem is not flashes. I never had them. It's both vaginal changes and impending osteoporosis. Both my gynecologist and my naturopath feel that there is good reason for me to try nat. prog. cream. One of them gave me a prescription that I had filled at a compounding pharmacy. I understand that I can also get compounded prescriptions at Women's' International Pharmacy. What do you all think of them?

I use Women's International Pharmacy for my testosterone cream prescription and they are convenient, fast and efficient.  They have two national locations and send your meds from the one closest to you.  I can set up my account to pay automatically with my credit card and order refills by telephone.  This works well for me as I would have to drive across the city to the nearest compounding pharmacist near where I live and that would be very annoying and time consuming.  I would expect that any of the mail order pharmacies would work as well.  They all provide the same products and price and service are their main competition points.  I don't know how others compare for price. 


As someone who has used NP both in OTC and prescription strength, my experience is that it used to help with certain perimeno symptoms, but now exacerbates them (and it never DID do anything for vaginal irritation/dryness for me). Go figure; obviously my body doesn't want it anymore! (I used it for several years before it started to "go wrong") 

Re: Dr. Lee - IMO, if something might make you feel better, it is certainly worth a try, but, IMO, I would be cautious assuming that using this would protect you from heart disease or osteoporosis. I have read Dr. Lee's book and he makes what are, IMO, many broad generalizations (one being that NP has "no" side effects - something I and others know from personal experience is patently NOT TRUE. That may be the case for some people, but for others, me included, it can make life miserable). Since I know at least ONE of his statements is untrue, it makes me doubt the BROAD truth of the others; I don't think it's impossible that this can help, but personally I am doubtful it will help everybody and therefore would not feel good about relying on it to do so. I guess if he were more specific and less broad in his comments about this being the thing for all women, I might think his studies worth more. IMO and in my experience, if it sounds to good to be true, it generally is. 

IMO, weight training and better diet are more proven ways of fighting potential osteoporosis. If the NP causes no bad effects for you, perhaps it will help you - I know women whom it HAS helped with peri/post-meno symptoms; the bone effect is harder to determine. Good luck, but IMO you'd be well served by using other methods of bone building in addition to the NP if you continue to use it. 

     We do not really know if any hormone, natural or synthetic, is safe for women with breast cancer. The challenge is to find the one with the lowest risk acceptable to each of us. At some point overall quality of life may matter more than a long and miserable life with constant fractures.
True enough; good luck! I hope this works for you. 
[email protected] 
    As yet,  I have seen no scientific studies or attempts at them, on the effects of prescription natural progesterone cream, except for the one done by Dr. Lee, who is obviously not on your accepted list of authorities to believe in.
This is correct.  Dr. Lee is going around the nation now trying to stir up interest in the scientific community to get more studies going on his theories.  At the recent seminar I attended it was obvious that many local doctors had been invited.  There were slips of paper with doctors names on them on the desk tops of about 100 chairs in the center of the auditorium. It is presumed that these doctors had been invited to attend the seminar to hear Dr. Lee speak and they must have all been off delivering babies or something because the big empty space was so obvious.  There were lots of doctors there, but they were also obviously (from their questions and behavior) all followers of doctor Lee.  They were the doctors of environmental medicine , the naturopaths, and holistic physicians. Mainstream medicine is not listening to him.  Why do you think this is?  I don't know. 

If you are going to self treat with OTC progesterone cream at least, please let your doctor know that you are doing it in case you should have a reaction to it.  The King's College doctors claim that it isn't well absorbed.  Dr. Lee swears that it is, but only shows up in saliva tests and they insist on using blood tests.  One day, I am sure we will know the facts.  Until we do, it pays to be careful. 

    There is no "magic"  or "specific" treatment.  If  you have read the extensive medical literature, as I have,  you will be aware that there are no treatments for problems resulting from menopause for women with breast cancer that may be considered without risk.
Ah, yes, for you with the breast cancer and for those with ovarian cancer, endometriosis and uterine cancer and the less serious but uncomfortable and complicating fibroids - the hope will be that NP cream is the answer for help with difficult meno symptoms - if we don't talk to our doctors about itt, I guess they will never take a look at what it is and what it does, because Dr. Lee sure hasn't gotten their attention.  My doctor said that it is only needed to maintain a pregnancy - totally useless otherwise, but then he has similar notions about the usefulness of the uterus - I suppose.  My doctor told me to go ahead and use it if I wished that it wouldn't hurt me. Doctors are a trip!  Mine then told me to consider using DHEA.  If you have heard Dr. Lee speak, you know that he says DHEA should not be used by women. Not enough is known about it in women.  Go figure.  I guess you have to educate yourself and then pick the doctor you want to trust based on whether or not he agrees with what you want to do. 


At a seminar I attended last night, Dr. John Lee totally dismissed a study about PMS as "just an attempt to sell prozac."  He does seem to have a heavy agenda, though, promoting transdermal progesterone (namely Pro-Gest®) and saliva tests (namely from Aeron). 

Maybe somebody can explain to me what he was trying to tell me about saliva tests and progesterone. He says that when you use transdermal progesterone it never appears in the blood plasma - only in the saliva.  When I questioned this because saliva is a blood filtrate - he said that all the progesterone in the blood is bound to cell protein.  So, if it stays bound in the blood; how can it get into the saliva? He also used a study from the British Journal of Cancer which showed women having surgery later in the cycle or having more serum progesterone having a higher survival rate than those having surgery earlier in their cycles.  His proposal from this was that it would increase the survival rate of all women having breast cancer surgery to use natural progesterone cream after surgery.  My question is how can he say this when he just said that you can't measure progesterone in the blood.  Those women weren't using his cream but just had more endogenous progesterone at the time of surgery - which was measured in the blood.  He couldn't answer my question so that I could understand it.  He just continued to say that his progesterone is passed into the saliva and the "other progesterone" is bound to cell protein on its way out of the body through the liver into the bile. 
fiona

    Hi  I had posted here a few days ago, after going through a complete hyst. Thanks to those of you who responded. I would like to take a minute and share my feelings.  It seems as though there is some controversy about Nat. Pro..  I hope I do not offend anyone by saying that I have taken NP for just about 3 months now.  I went through it all before surgery as far as treatment goes.  I took NP to try to inhibit the growth.  It did not work.  However, I do believe that taking NP has definitely helped me with the menopausal symptoms.  I started to get hot flashes 6 days after surgery and thought I wouldn't make it through the day.  I increased my Vit E intake and I am happy to say 4 days after they are less frequent and intense.  I am having a hard time with migraines though, I'm not sure what to do about that.  I did read Dr. Lee's book.  I found although it didn't have yrs of testing to support its claims, the info gathered made sense to me. I am pleased with the results thus far, I hope it continues. Perhaps I am just lucky, who knows.  I am a bit interested in what all the controversy is about?  If anyone is interested in letting me know, I would appreciate it. Thanks..
Without scientific validation it is considered in some circles to be irresponsible, exploitive and dangerous to sell commercial products for which health claims can not be substantiated. 

Anecdote and personal testimony may be adequate for some who wish to experiment with commercial products costing $35 a month along with confirming saliva tests that cost several hundred dollars when these products fail to work as promised, but this may also be considered foolhardy and sham by others. 

The issue of controversy is only over whether a product market should be driven by personal testimony or scientific fact. And the controversy is when these two marketing features get confused. You presented personal testimony and some of us feel that scientific fact is also required when these commercial products are discussed and/or marketed. 

And how can one tell who is really posting what on this medium? How do we know your personal story is legitimate or whether you are just trying to sell drugs? We call all look up cited scientific articles and reach our own conclusions, but personal testimony can only stand alone until it is adequately validated. 

Recently a poster who sells these products finally admitted they didn't do a darn thing for menopausal symptoms while she zealously cried out that we should all try them and charged this need was based upon her reaction to our personalities, and that she had declared anyone who criticized her sales techniques as "hags" in sure need of her wares. 

What would make a poster react like this over this product? Is this credible marketing of a credible product? If this is not controversial and offensive marketing about sham products, I don't know what more you need to see about this issue. 

When you have signs and symptoms of menopause that are (1) subjective and (2) episodic, it is very hard to make competent decisions to transfer $35 a month to some stranger for a product that has no science behind it. Why not transfer $35 to yourself and save up for something more fun and worthwhile? Or donate it to a scholarship at your local community college? Why transfer $35 a month for a placebo product unless you think it has some validity? And how do we get that validity? 

Your personal experience has many holes in it to call it science. First who knows who you are and this is not meant to be an attack but women who sell these products come on all the time with suspect personal testimonies. You are dealing with symptom alleviation that is highly individualistic in any circumstance. There has been shown to be no therapeutic dose in any of these OTC cremes which means that the placebo effect must also be accounted for. Placebo runs as high as 60% for meno effect, why this specific product and why $35 a month for placebo? Why not placebo from something that costs no money? 

The efficacy of a product validates itself over time and multiple experiences.. You own experience may be short lived but we will never know that unless you choose to report it beyond your first flush of success.  And your first flush of success may well be a coincidental variation of symptoms, which would happen no matter what you did or took at this time. 

No one is ever saying not to try with whatever level of body experimentation you feel comfortable with. But you asked what all the fuss was about a product that is giving you some personal success. I am only providing context for why there is reasonable controversy over the use of this product and the transfer of $35 a month to some stranger for it. 

Everyone is looking for comfort and it is good you have found your own. Your personal story is important and it will be added to the other personal stories of women who have not found your level of success with use of this product. And in time with enough responsible and complete stories, we may actually learn something about it. 
Shelly 



 Hang in there kiddo.  Glad you are still here and reading and posting.  I'm glad you have found some help with the NP cream.  I am a little confused by what you said about before the surgery.  Did you use NP cream to stop the endo?  Have you ever heard of anyone having it stop endo other than in Dr. Lee's book?  I read the alt.support.endometriosis list and haven't heard anyone post there that it has stopped endo.  I have read MLM sales hype testimonials claiming such results, but you can usually recognize these things by the number of exclamation points used in them.  Aside from that, you say that NP cream helps your hot flashes.  I'm glad for you!  There was another poster here who said that it helped her surgical meno hot flashes too; so you are not the first.  Maybe it will help you so well that you won't even need to take estrogen and won't need to worry about the estrogen risk factors.  Since you are getting good results with the cream, if it's not a prescription cream you are using, you might want to get the prescription kind as it may be less expensive and might be covered by medical insurance and you can get it made stronger.  The only risky thing about that is we don't know if there are any long-term risk factors for NP cream.  Good old Dr. Lee says it's "perfectly safe" = no risk factors.  You just have to ask yourself if you are willing to take his word for it. 
Fiona
Quite a while ago, I'd been seesawing from one hormone treatment to the next for various reasons, and one of the regimens I was interested in was this Natural Progesterone. I ordered it from the States through the net, read Dr Lee's book, (where I come from, there is simply no knowledge of this method of HRT)  and thought ok - lets see.  Well, after the first day even, I really did feel grotty - tired, depressed, bloated and just generally out of sorts.  I persevered, and after about 6 weeks, I gave it up  - it  made me feel like a wet rag most of the time. . I felt terrible throughout those 6 weeks - perhaps I didn't give it enough time? - who knows.. but I've been doing some reading on it, and it does seem as if its not all the hoo-ha its supposed to be. YMMV, though.. :)  This is just my personal experience.
Karen M. d'U
    When one has a hysterectomy, your estrogen level drops 40-60%, but is still actively produced.  Your progesterone level drops to just about nothing.   YET, the Dr's insist upon supplementing us with estrogen, NO progesterone. Of course this is my opinion, but what about the progesterone?
Progesterone is the hormone which maintains pregnancy and protects the endometrium so most people do not think it is necessary for someone without a uterus. Claims otherwise have been made but these have not been verified. Certainly some posters here have found relief from hot flashes using progesterone alone when they have not been able to take estrogen because of cancer.  Another reason for not using a progestin where it is not clearly required for endometrial protection is that it reduces the putative good effect of estrogen on the blood lipids. Provera is  often used (without estrogen) to combat heavy bleeding - obviously this is not after a hysterectomy though.
     Many women still opt to use HRT, despite some unpleasant side effects.
Are you meaning to imply that natural products do not? I can assure you they do in some cases, though certainly progesterone shows far fewer and less severe ones than Provera. Provera however has been in use for a long time - and has been shown to be successful in protecting the endometrium. Often it is a case of using what the doctor will prescribe and many doctors consider it unethical to prescribe products without long term testing.. However anybody using any of the patches (or Estrace) is in fact using natural estrogen - and many women do use these forms. Here in Canada we have oral micronized progesterone under the trade name Prometrium and its use is increasing - having the brand name and easy availability naturally makes it more popular, and it's standardization and approval by Health Canada gives doctors more confidence in its efficacy. It was used in the PEPI study recently so has some solid mainstream research behind it. Even so, this was only a three year (I think) study. In the US it is more difficult to get since it has to be obtained from a compounding pharmacy. Also doctors are leery about the standardization.
    From what I understand,  most people who suffer from "womanly" problems have been diagnosed as being estrogen dominant.
Ahh, stop right there. That is the nub of the question I think.   The term estrogen dominant is  new, I don't know who coined it but it is used only by people who promote the use of natural progesterone creme. I was sure it was a long standing term, until I started to look back in my old PMS books. Back then "womanly" problems were considered to be due to hormone imbalance. Katherine Dalkon, our PMS heroine, said that women could have either high or low progesterone levels relative to estrogen. 
    YET, the Dr's insist upon supplementing us with estrogen, NO progesterone. Of course this is my opinion, but what about the progesterone?
This is another key point.. I would guess that progesterone is not prescribed because progesterone is not needed by the body if you are not reproductive. I know that this flies in the face of the people who are promoting the use of natural progesterone creme. And I am not trying to say that natural progesterone may not work as well as supplementary estrogen to alleviate symptoms due to a sudden drop in estrogen with surgical menopause.  In fact I have a reference to a study (I have not read the study just seen the reference) that found that "estrogen and progestin are equally effective in symptom control post-ovariectomy". This was a one-year, double-blind, randomized trial. But I do not think this is what you mean as an alternative to ERT when you say NHRT. 

There have been studies to support the use of progesterone with the term used in the general sense, such as the study I mentioned above. These are not NHRT studies. Jerilynn Prior, an endocrinologist has done some research and is quite enthusiastic about the use of progesterone. She has her own version of the estrogen dominance theory, she calls it "perimenopausal ovarian hyperstimulation". This is of course for women who have ovaries and who have at times too much estrogen. She feels this may be quite common just before menopause and is the cause of heavy bleeding, fibroids, and endo at this time. She does not talk about too little progesterone because progesterone in her opinion as an endocrinologist is only required for reproduction.  But she is talking about peri-menopause and your questions on NHRT were on women with a surgical menopause were they not? Are we talking about apples and oranges?  Jerilynn Prior feels that women with these estrogen upheavals (or what you seem to call estrogen dominance) should not take any supplementary estrogen until at least 1 year past their final period. This sure makes sense to me. But I don't know if that helps with your question on why do women take HRT. I don't see how a natural estrogen would be any different.  Or do you think these women with too much estrogen should take a progesterone to counteract the estrogen? Yes Jerilynn Prior suggests this may help women with severe symptoms. But this is not hormone replacement, this is hormone treatment or therapy. Do you understand the difference? There is certainly not anything natural about it. Either a progestin such as Provera or a natural progesterone such as (in Canada) Prometrium can be used to counter the effects of the estrogen. Either will work. Some would say that the natural progesterone has fewer side effects. 

 I do not know about the women who choose to do HRT. I had so many problems with my hormone levels during peri that adding to the problem by taking supplementary hormones did not make sense to me.

Perhaps it would help us if you describe what you mean by NHRT? I also suggest that you go to tishy's unofficial webpage and look at the Ovarian Hormone Therapy page and see why she thinks that OHT is a better way to describe the taking of supplementary hormones then to use the term  HRT.  This may clear up a lot of the misunderstanding some of us are having with the term NHRT.  I just looked at the ng, and see your questions have generated a lot of response. I hope you do not feel jumped on, this is an issue that does need to be clarified if we are to understand each other and share experiences 
Kathryn

Some Women Cannot Abide Progesterone  note: You may have problems accessing this site using Netscape
Extract fromhttp://members.nbci.com/diff_drummer/index2.html

We're up front about this site being one sided. Some women have bad reactions to progesterone
products. Hardly anyone is listening. Some women should not be using progesterone. You may be one of them. You will have to make that decision for yourself, we're not here to diagnose or to convince you either way. Read the contraindications, consider your medical history both physical and mental, take a close look at your state of mind and then read the stories. You may recognize yourself in another woman's story. If that's the case, take a closer look at the known negative effects to progesterone, reconsider your physical and mental medical history with a bluntness and if necessary, research some more. 

 Don't let this website convince you that you should not be taking progesterone. And by the same measure, don't let any mailing lists convince you that you should. Research, research, research. 



To read personal accounts of bad reactions to progesterone, go to http://members.nbci.com/diff_drummer/P-Club/clients.html 

OVARIAN HORMONE THERAPY

General - risks, definition of NHRT Which OHT?  Deciding on it  Getting off it  "Natural" hormones Long term considerations
  natural progesterone 
  natural estrogens
  definition of NHRT
To Welcome
Hosted by www.Geocities.ws

1