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Chloroquine:
Commonly used in endemic areas
Resistant by the falciparum species
Administered orally before a severe attack, otherwise it is administered intravenously
Quinine:
Before chloroquine was developed, it was the original drug in the first line of treatment
Taken when resistance is developed to chloroquine
Administered orally for 7 days and followed by a 7-day course of tetracycline.
In severe infections, administered slowly intravenously
Mefloquine:
Often combined with chloroquine or quinine to overcome resistance
Administered orally and absorbed rapidly
Very long acting
Halofantrine:
Used for acute forms of falciparum malaria
Administered orally and irregularly and slowly absorbed
Folate Antagonists:
Administered orally after a 7-day course of quinine for some falciparum malaria acute attacks
Primaquine:
Often used for a radical cure but not for vivax and ovale malaria.
Antibiotics:
Used in combination with quinine for a 100% cure.
Vaccine:
Currently no vaccine is available. However, many scientists are currently working on vaccines and some are on trial now.
Travelers to malaria endemic areas can take preventive medication but not a vaccine.
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