Analgesics, Anti-asthmatics, Endocrine Pharmacology, GIT Pharmacology

41.    Colchicine:

a.     acts by inhibiting prostaglandin cyclo-oxygenase.

b.    is mainly excreted unchanged in the urine.

c.    lowers the serum uric acid level in hyperuricaemia.

d.    is effective for acute gout.

42.    The following drugs may cause bone marrow depression:

a.     chloramphenicol.

b.     methotrexate.

c.     phenylbutazone.

d.     propylthiouracil.

43.    Effects of the local anaesthetics are influenced by:

a.     route of administration.

b.     degree of ionization of the drug.

c.     inactivation by serum or liver enzymes.

d.     use of vasoconstrictors.

44.   Lignocaine differs from procaine in that it has:

a.     greater potency.

b.     is metabolized by the liver.

c.     is longer acting.

d.     is rapidly hydrolyzed by plasma esterase.

45.    Paracetamol:

a.      can cause liver toxicity.

b.      has a toxic metabolite.

c.      has anti-platelet actions.

d.      inhibits prostaglandin cyclo-oxygenase.

46.    Phenacetin:

a.      is metabolized to paracetamol.

b.      can cause methaemoglobinaemia.

c.      has anti-inflammatory action similar to aspirin.

d.      is a uriocosuric agent.

47.    Caffeine:

a.      has no therapeutic value.

b.      is added to certain beverages.

c.      does not increase gastric secretion.

d.      causes ventricular ectopics.

48.    Plasma concentration of theophylline:

a.      correlates well with clinical relief of bronchospasm.

b.      does not correlate well with clinical toxicity.

c.      may rise disproportionately with dosage increase.

d.      is a useful value when taken under steady conditions.

49.    Allopurinol potentiates:

a.      5-fluorouracil.

b.      6-mercaptopurine.

c.      azathioprine.

d.      methotrexate.

50.    Sulindac as the sulfoxide:

a.      is useful for renal-compromized patient.

b.      is a pro-drug.

c.      is predominantly eliminated by active renal secretion.

d.      has a plasma half-life of about 18h.

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