Analgesics, Anti-asthmatics, Endocrine Pharmacology, GIT Pharmacology

51.    In salicyclate poisoning:

a.     forced diuresis is hazardous.

b.    the proportion that is protein bound increases due to acetylation of albumin.

c.    alkalinization is not recommended because it may aggravate metabolite alkalosis.

d.    there is hypochloremic metabolic alkalosis.

52.    Insulin:

a.     release is stimulated by biguanides.

b.     from pig is more antigenic than from cow.

c.     cannot be given orally.

d.     when combined with protamine has prolonged duration of action.

53.    Tolbutamide:

a.     acts by increasing insulin uptake by tissues.

b.     shorter acting than chlorpropamide.

c.     metabolized to an active metabolite.

d.     dose should be decreased in renal failure.

54.   The following may be associated with prolonged hydrocortisone therapy:

a.     hyperkalaemia.

b.     hypercalcaemia.

c.     hyponatraemia.

d.     alkalosis.

55.    Possible side effects from long-term usage of oral contraceptives include:

a.      gallstones.

b.      thromboembolism.

c.      impaired glucose tolerance.

d.      hypertension.

56.    Ranitidine:

a.      is a potent H1 receptor blocker.

b.      is not known to inhibit hepatic microsomal enzymes.

c.      decreases gastric acid secretion..

d.      has no effect on pepsin secretion.

57.    Bulk purgatives include:

a.      bran.

b.      bisacodyl.

c.      carboxymethylcellulose.

d.      dioctyl sodium sulfosuccinate.

58.    Long-term use of aluminium and magnesium hydroxide compound tablets is associated with:

a.      abdominal distension.

b.      milk-alkali syndrome.

c.      phosphate depletion.

d.      renal calculi.

59.    Cimetidine:

a.      prevent histamine-induced bronchospasm.

b.      inhibit hepatic microsomal enzymes.

c.      can cause gynaecomastia.

d.      is excreted mainly unchanged by the kidney.

60.    Insulin:

a.      stimulates glycogen breakdown in liver.

b.      stimulates protein breakdown in muscle.

c.      promote gluconeogenesis.

d.      promote transport of glucose across muscle cell membrane.

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