Analgesics, Anti-asthmatics, Endocrine Pharmacology, GIT Pharmacology

61.    Tolbutamide:

a.     stimulates beta-cells of pancreas to release insulin.

b.    is converted by the liver to a more potent agent.

c.    is longer-acting than chlorpropamide.

d.    is highly bound to plasma proteins.

62.    Carbimazole:

a.     can cause bone marrow suppression.

b.     mainly metabolized by the liver.

c.     is secreted in breast milk.

d.     crosses the placenta.

63.    Parathyroid hormone:

a.     inhibits bone resorption.

b.     decreases intestinal absorption of calcium and phosphate.

c.     decreases renal reabsorption of phosphate.

d.     increases the formation of 1,25-dihydroxycalciferol from 25-hydroxycalciferol by the kidneys.

64.   Corticosteroids with predominantly glucocorticoid activity include:

a.     dexamethasone.

b.     aldosterone.

c.     betamethasone.

d.     triamcinolone.

65.    Allopurinol inhibits:

a.      renal tubular reabsorption of uric acid.

b.      synthesis of purine.

c.      phagocytosis of urate crystals.

d.      conversion of xanthine to uric acid.

66.    Chronic administration of dexamethasone is likely to cause:

a.      immunosuppression.

b.      Na and water retention.

c.      hypertrophy of the skin.

d.      muscle wasting.

67.    Cimetidine:

a.      has both H1 and H2 antagonistic actions.

b.      half-life is 12h.

c.      is used to treat duodenal ulcer.

d.      increases sleeping time in mice by anti-histamine action in the CNS.

68.    Drugs that can counteract effectiveness of tolbutamide therapy include:

a.      adrenaline.

b.      ampicilin.

c.      hydrocortisone.

d.      dicoumarol.

69.    Insulin preparations that have duration of action more than 8h are:

a.      lente insulin.

b.      protamine zinc insulin.

c.      soluble insulin.

d.      biphasic insulin.

70.    Cocaine:

a.      is not used as an infiltrating LA.

b.      stimulates the CNS.

c.      has addiction liability.

d.      is effectively applied topically to mucous membrane.

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