Analgesics, Anti-asthmatics, Endocrine Pharmacology, GIT Pharmacology

21.    Corticosteroids are useful for:

a.     anaphylaxis.

b.    atopic dermatitis.

c.    herpes simplex eye infection.

d.    rheumatoid arthritis.

22.    The long-term effects of large doses of corticosteroids include:

a.     decreased gluconeogenesis.

b.     decreased potassium secretion.

c.     re-distribution of body fat.

d.     osteoporosis.

23.    Thyroxine:

a.     increases tissue oxygen consumption.

b.     produces an increase in liver glycogen.

c.     decrease the level of plasma cholesterol.

d.     increase glucose absorption from GIT.

24.   Methimazole:

a.     inhibits the coupling of mono-iodotyrosine and di-iodotyrosine.

b.     inhibits TSH-induced release of thyroxine.

c.     inhibits the iodination of mono-tyrosine.

d.     inhibits iodide trapping.

25.    Disodium cromoglycate:

a.      is a direct-acting bronchodilator.

b.      is admitted by inhalation.

c.      stabilizes mast cell membranes.

d.      relieves signs and symptoms in an acute attack.

26.    Progesterone:

a.      changes a secretory endometrium to one that is proliferative.

b.      inhibits LH and FSH.

c.      stimulates the release of MSH.

d.      improves acne.

27.    The following are the mode of action of the corresponding drug:

a.      carbenoxolone sodium neutralizes gastric acid.

b.      metoclopramide delays gastric emptying.

c.      propantheline acts as an anti-cholinergic drug.

d.      Mg(OH)2 increases production of mucoprotein.

28.    Combined oral contraceptives:

a.      inhibit the metabolism of imipramine.

b.      decrease the effect of anticoagulants.

c.      increase brain tumor incidence.

d.      increase appetite.

29.    Drug interaction arising from the use of antacids include:

a.      the chelation of tetracycline with sodium ion.

b.      the absorption of digoxin by aluminium compounds.

c.      delayed absorption of chlorpropamide.

d.      delayed excretion of amphetamine due to elevated urine pH.

30.    Administration of a local anaesthetic containing noradrenaline may cause a severe rise in blood pressure in patients on:

a.      guanethidine.

b.      propranolol.

c.      amitriptyline.

d.      pethidine.

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