Analgesics, Anti-asthmatics, Endocrine Pharmacology, GIT Pharmacology
1. Drugs that are likely to cause Na and water retention include:
a. T
b. F
c. T
d. T
2. Adverse drug reaction caused by antacids include the following:
a. F: causes constipation.
b. T
c. F
d. F: caused by calcium bicarbonate.
3. Cimetidine:
a. T
b. F: 50% excreted unchanged; the remainder is converted to a sulphoxide by the liver.
c. T
d. F: blocks H2 receptors.
4. Theophylline:
a. T
b. T: used as an adjunct to beta2-agonists.
c. F: inhibit phosphodiesterase thereby increasing cAMP levels in bronchial smooth muscle.
d. T
5. Prolonged use of corticosteroids as in immunosuppression predisposes to:
a. T: due to inhibition of DNA synthesis and cell division.
b. T: due to suppression of hypothalamic-pituitary-adrenal axis leading to decreased ACTH release.
c. F: there is reduced bone formation, increased loss of calcium and bone protein mobilization.
d. F: proximal myopathy occurs due to mobilization of muscle proteins.
6. Problems associated with the use of regular insulin:
a. T
b. T
c. F
d. T
7. Chlorpropamide:
a. F: 20 - 30% excreted unchanged by the kidneys.
b. T: half-life of 24h.
c. T
d. T
8. Allopurinol:
a. F: acts by inhibiting xanthine oxidase.
b. T
c. F: azathioprine is metabolized to 6-mercaptopurine in the body; allopurinol inhibits the oxidation of the latter to an inactive metabolite, thereby potentiating its effects.
d. F
9. Lignocaine:
a. F: undergoes extensive systemic first-pass in the liver.
b. F
c. T
d. T
10. Procaine:
a. F
b. T
c. T
d. T.