Pharmacology of Antimicrobials and Cytotoxic drugs

51.    The following tetracycline(s) is/are safe to use in renal failure:

a.      doxycycline.

b.      minocycline.

c.      methacycline.

d.      chlortetracycline.

52.    The following bacteria is/are sensitive to gentamicin:

a.      Streptococcus pyogenes.

b.      Escherichia coli.

c.      Klebsiella spp.

d.      Streptococcus pneumoniae.

53.    Gentamicin:

a.      is well absorbed orally.

b.      has a low therapeutic index.

c.      is mostly metabolized by the liver.

d.      can enter into the CSF.

54.    Penicillins:

a.      after absorption are widely distributed throughout the body.

b.      are excreted mainly by renal tubules.

c.      enter the CSF in effective concentration in meningitis.

d.      cause hypersensitivity reaction.

55.    Vidarabine:

a.      enters CSF readily.

b.      is excreted mainly by the kidney.

c.      is active against RNA viruses.

d.      and its metabolites have equivalent anti-viral activity.

56.    Nystatin:

a.      inhibit fungal cell wall synthesis.

b.      is well absorbed orally.

c.      is used in the treatment of systemic mycosis.

d.      is used in the treatment of candidiasis of the oropharynx.

57.    Vancomycin may produce the following adverse effect(s):

a.      renal damage.

b.      8th nerve damage.

c.      thrombophlebitis.

c.      chills and fever.

58.    The following inhibit bacterial protein synthesis:

a.      penicillin.

b.      aminoglycosides.

c.      erythromycin.

d.      clindamycin.

59.    The danger of crystalluria with sulfonamides is reduced by:

a.      potassium citrate.

b.      sodium bicarbonate.

c.      ammonium chloride.

d.      increased intake of water.

60.    A 64-year-old man was admitted with peritonitis in state of shock. He has a history of diverticulitis which probably caused the peritonitis. What should be the effective antibiotic therapy:

a.      cefotaxime + gentamicin.

b.      cloxacillin + cefotaxime + gentamicin.

c.      penicillin G + gentamicin + metronidazole.

d.      ampicillin + streptomycin + cefoxitin.

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