Pharmacology of the Cardiovascular and Central Nervous Systems

61.    An acute attack of angina should be treated with:

a.     glyceryl trinitrate.

b.     propranolol.

c.     morphine. 

d.     pentaerythritol tetranitrate.

62.    The following drugs decrease conduction in the Bundle of His:

a.     quinidine.

b.     lignocaine.

c.     phenytoin.

d.     digoxin.

63.    Quinidine:

a.     increases PR interval.

b.     decreases QT interval.

c.     decreases heart rate.

d.     increases heart rate. 

64.   The characteristic ECG changes produced by cardiac glycosides:

a.      prolonged PR interval.

b.      shortened QT interval.

c.      depression of ST segment at high doses.

d.      increased amplitude of T wave.

65.    Digoxin increases:

a.      efficiency of both normal and failing hearts to the same extent.

b.      cardiac output in failing heart without corresponding increase in oxygen consumption.

c.      duration of systole.

d.      vagal tone.

66.    Sodium nitroprusside:

a.      relaxes only venous smooth muscle.

b.      has onset of action greater than 10 minutes after start of IV infusion.

c.      half-life is only less than 30min.

d.      decomposes on exposure to light.

67.    Clonidine:

a.      has a half-life of less than 10min.

b.      inhibits the release of renin.

c.      decreases cardiac output.

d.      produces rebound hypertension less frequently than methyldopa.

68.    Hydralazine:

a.      is a stronger venodilator than arteriodilator.

b.      can cause systemic lupus erythematosus.

c.      is metabolized by hepatic acetylation.

d.      is liable to cause impotence in males.

69.    Digoxin:

a.      is excreted primarily by the kidney.

b.      have a longer half-life than digitoxin.

c.      is completely absorbed from the gut.

d.      action is counteracted by calcium.

70.    The effect of digoxin on the myocardium is enhanced by:

a.      potassium.

b.      calcium.

c.      propranolol.

d.      procainamide.

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