Pharmacology of the Cardiovascular and Central Nervous Systems
11. The following unwanted effects may result from the use of glyceryl trinitrate:
a. T
b. F
c. T
d. T
12. Direct effects of quinidine on the heart include:
a. T
b. F
c. T
d. T
13. Thiazides:
a. T
b. F
c. T
d. F
14. The following anti-hypertensive agents are known to cause CNS depression:
a. T: depletes adrenergic nerves of noradrenaline by blocking or destroying the storage mechanism within the nerve entirely.
b. F
c. F
d. T: acts on central alpha2 receptors.
15. Phenytoin:
a. T
b. T
c. T
d. T
16. Naloxone:
a. T
b. T
c. T
d. F
17. The following general anaesthetic agents are explosive:
a. T
b. T
c. F
d. F
18. Heparin:
a. T
b. T
c. F
d. F: enhances activity of antithrombin III which inactivates Factor X.
19. Tricyclic antidepressants:
a. T
b. T: onset of action can take 2 - 4 weeks.
c. F: have no effects on normal individuals.
d. T
20. The pharmacokinetic properties of benzodiazepines include the following:
a. T: oxazepam penetrates the brain slowly and accounts for its smooth action.
b. T: it is the active metabolite of diazepam, clorazepate, prazepam, halazepam and flurazepam; it is hydroxylated to oxazepam.
c. T: termazepam has a half-life of 13h compared to diazepam's 30h.
d. T