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CURRICULUM VITAE |
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This CV is also available
for download in the following formats: |
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 Microsoft
Word Format |
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 Adobe
PDF Format |
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KOSTAS
LYKOSTRATIS
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PERSONAL INFORMATION: |
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Nationality:
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Greek |
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Date of Birth:
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29/01/1980 |
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Status:
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Single |
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EDUCATION: |
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2002 |
PhD, Bioinformatics &
Systems Biology |
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University of London
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Thesis: Computational
Modelling of the Dynamics of Signalling Pathways |
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Description: In this
project, computational models of signal transduction processes
will be built, and predictions from the models will be
compared to experimental results. The aim will be to develop
an understanding of the importance of the different stages
in the signal transduction processes involving Rho, to
explore the effects of and sensitivity to changes at different
stages, and, ultimately, to explore how cytoskeletal rearrangement
and cell motility can be controlled. It is essential that
the computational modelling is closely linked to experimental
work, with the goal of developing an interaction between
model and experiment. Effort will be focused on the design
and implementation of a relational database, generation
of computer models, complementary experimental tests and
refinement and expansion of software tools. |
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Techniques: Systems Biology
software; Database design; Java programming; Perl scripting. |
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2002 |
MRes, Bioinformatics (Awarded
Distinction) |
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University of York |
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 Biological
sequence analysis |
Machine
learning |
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Programming
in Perl |
Pattern
recognition and Neural Networks |
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Programming
in JAVA |
Molecular
aspects of disease |
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Databases |
Structural
Bioinformatics |
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2001 |
BSc, Human Genetics |
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University of Leicester |
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2:1 Honours degree. |
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1998 |
Panhellenics (Greek A-Level
Equivalent) |
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Skydra Senior College |
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Biology (85%), Chemistry (80%),
Physics (70%), Modern Greek Literature (66.5%) |
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RESEARCH EXPERIENCE: |
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May - Sept 2002 |
Astra Zeneca R&D (MRes
External placement) |
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Design of an Automated SNP Viewer |
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The project involved the design
of a system for automated mining of SNP-information and
the generation of new information previously unavailable.
An interactive viewer was developed to aid visualisation
of the gene of interest, the coding region, the SNP locations
and the effects of the polymorphisms at the protein level.
The developed system was used as a template for the identification
of SNPs that might play key role in disease genes or genes
with differential behaviour on drugs and medical treatments.
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Techniques: Perl programming,
JAVA programming, CGI scripting, HTML editing, SRS. |
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Feb-Apr 2002 |
MRes project II |
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Identification of conserved
core structures and residues in kinesins |
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Structural alignments of all
the kinesin motor domain structures confirmed that these
enzymes share a common core structure and revealed extensive
similarity located outside the conserved nucleotide binding
site residues. A model structure composed of the structurally
invariant core residues was constructed. This model was
subsequently used to scan the entire RCSB PDB database
for structurally similar proteins. |
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Techniques: Molecular
structure analysis, multiple structural alignments and
Perl scripting. |
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Nov-Dec 2001 |
MRes project I |
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Computational Analysis of Microarray Data
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Techniques: Examination
of gene expression levels of 1611 genes using Hierarchical
clustering, K-means clusteing and Principal Component
Analsysis. |
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Oct 2000 - Apr 2001 |
BSc final year project |
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Investigation into the methylation
state of Caspase 8 and E-cadherin in cancer cell lines
and formalin fixed tissues from neuroblastomas. |
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June - Sept 2000 |
Research assistant |
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Leicester Royal Infirmary |
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Developing experimental protocols
for the design and refinement of a new experimental
technique: DNA bisulfite treatment and Methylation
Specific PCR. |
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SKILLS |
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Computing |
Bioinformatics Software: |
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Systems
Biology Modelling (SBW, Jarnac, Jdesigner, E-Cell, Virtual-Cell,
GEPASI, SBML, |
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and others); |
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Molecular
Modelling (Quanta, Rasmol, VMD, SwissPDB) |
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Structural
& Sequence Alignments (CAMINE, VAST, DALI, ClustalX,
GCG package, BioEdit,
17HMMer,
PSI-BLAST and others) |
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Phylogenetic
Analysis (Treeview, PAUP) |
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Microarray
Data Analysis (EisenLab Cluster-Treeview, Jexpress, AMANDA,
GENESPRING,
TIGR
MultipleExperimentViewer) |
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Other Software & Operating Systems:
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Microsoft
Office |
Reference
Manager |
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Macromedia
Dreamweaver |
Macromedia
Flash |
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Corel
Draw |
Adobe
Photoshop |
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Windows
operating systems |
Unix-Linux
operating systems |
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Development |
Programming Languages and
Database Systems |
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JAVA
(Applets, Applications, Servlets, JSPs, SWING-AWT, Graphics
2D) |
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PERL
(CGI, Tk) |
JavaScript |
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HTML |
XML |
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SQL
(ORACLE 8i, MySQL) |
Unix
shell scripting (Bash, T-shell) |
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Languages |
English
and Modern Greek |
Basic
French and Italian |
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AWARDS |
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Best Annual Poster Presentation,
Biological Sciences Department, University of Leicester
2001 |
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