What is Prostate Cancer ?
Prostate Cancer is in the industrial countries after lung cancer the most frequent cancer by men,
but probably will become the number 1. This is due to the higher average age of the people and
because prostate cancer is discovered earlier. Mostly older people rather die with prostate
cancer than from prostate cancer.
Prostate cancer is like other cancers a disease of uncontrolled cell growth. The prostate is about
the size of a walnut. The prostate makes fluid that becomes part of the semen, the white fluid that
contains sperm. A doctor should be seen if any of the following symptoms appear: weak or
interrupted flow of urine, urinating often (especially at night), difficulty urinating, pain or burning
during urination, blood in the urine, or nagging pain in the back, hips, or pelvis. Often there are
no
symptoms of early cancer of the prostate. When examining a patient, a doctor will insert a gloved
finger into the rectum (a rectal examination) to feel for lumps in the prostate. A special test called
an ultrasound, which uses sound waves to make a picture of the bladder, may also be done.
If the doctor feels anything that is not normal, he or she may need to take cells from the prostate
and look at them under a microscope. The doctor will usually do this by putting a needle into the
prostate to remove some cells. To get to the prostate, the doctor may put the needle through the
rectum or through the space between the scrotum and the anus (the perineum). This is called a
fine needle aspiration or a needle biopsy.
Also doctors can take a blood test to measure the PSA (Prostate Specific Antigen). A normal
PSA is in the range from 0 to 4. This antigen comes from prostate tissue or malignant prostate
cancer cells. The higher numbers in advanced disease is consistent with higher volumes of tumor
cells present in advanced prostate cancer. A high PSA level could also be caused by infection or
prostate enlargement (BPH)
If prostate cancer cells escapes the prostate we speak of metastases. Prostate
cancer cells can spread to lymph nodes, the bones or organs. Recurrent prostate cancer means
the prostate cancer has come back after a treatment.
Treatment Options local disease:
Radiation :
Advantages : Cure possible, no chirurgic treatment.
Disadvantages: Long treatment, difficult monitoring of recurrence, 10% incontinence, 20-30 %
impotence, 10-20 % bladder damage.
Radical prostatectomy :
Advantages : Cure possible, easy monitoring recurrence
Disadvantages : Big surgery, mortality 0,3% , impotence > 50%, incontinence 30-50%,
bleeding 5%.
Experimental treatments :
- Laser therapy
- Cryo ablation (freeezing the cancer using small probes)
- High Intensity Foccused Ultrasound (HIFU)
- Brachytherapy
Treatment options prostate cancer outside the prostate (without metastases)
- Watchful waiting
- Hormonal therapy ffollowed by surgery
- Hormonal therapy ffollowed by radiation therapy
- Hormonal therapy aalone
- Intermittent hormoonal therapy
The hormonal treatment consists of LHRH agonists together with anti-androgens
Treatment of metastasized prostate cancer
Metastasized prostate cancer is treated with hormonal therapy to decrease the amount of male
hormones, sometimes the testicles are removed to stop the testicles from making testeron.
Side effects of hormonal treatment are : growth of breasts tissue, hot flashes, impaired sexual
function, and loss of desire for sex. Hormonal therapy temporary arrests prostate cancer cell
growth, thereafter the prostate cancer becomes hormone refractory and the treatment options
become very limited. The average survival time of men with hormone refractory prostate cancer
is 9 months. Chemo therapy and/or palliative treatment are the only options.
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