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| ANIMALS OR BABIES? |
| It is NOT a choice between animals or people - but between experiments on animals (the results of whch cannot be applied to any other species, including humans) or research which relevant to humans. |
safety testing? |
| ANATOMY and PHYSIOLOGY: An editorial in `The Lancet! stated "It is notoriously dangerous to apply experimental results from animals to the treatment of human beings because humans and animal physiology show subtle but important differences" HUMAN RESPIRATORY SYSTEM differs from that of RATS, small RODENTS - mucus cavity and secretion differs from that of MICE, RATS, HAMSTERS CATS, RABBITS, DOGS - the lungs differ from those of RATS, AMPHIBIANS, REPTILES, FISH, BIRDS - the respiratory rate differs from that of HORSES, SHEEP, GOATS, PIGS, DOGS HUMAN AORTA of the HEART differs from that of DOGS HUMAN HEART MUSCLE CELLS differ from those of RATS, GUINEA PIGS, CATS, RABBITS, PIGS, MONKEYS, CATTLE, FROGS HUMAN NERVES CENTRES of the BRAIN differ from those of CATS HUMAN CENTRAL NERVOUS SYSTEM differs from that of RODENTS, FROGS HUMAN EYE differs from that of RABBITS - the retina differs from that of CATS, MONKEYS, FROGS, FISH, TORTOISES, TURTLES, SNAKES, CHICKENS, PIGEONS HUMAN COCHLEA of the EAR differs from that of GUINEA PIGS HUMAN NEPHRONS of the KIDNEYS differ from those of RATS, DOGS, BIRDS, AMPHIBIANS, REPTILES HUMAN LIVER differs from that of MICE, RATS, DOGS, AMPHIBIANS, REPTILES, BIRDS HUMAN SKIN differs from the skin of MICE, RATS, GUINEA PIGS, RABBITS, FROGS HUMAN PANCREAS differs from that of MICE, DOGS |
DISEASES Less than 2% of all human diseases are ever seen in animals - so experimenters try to create an animal "model" - but such artificially induced diseases in animals are not the same as diseases occuring naturally in human beings. ARTHRITIS in HUMANS differs from the "air pouch technique" in RATS, cotton- wrapped cartilage implant in MICE; induced oedema swelling in RABBITS ASTHMA in HUMANS differs from Ascari-induced bronchospasm in DOGS - early response in HUMANS differs from that in RATS, RABBITS, MONKEYS, CATS, SHEEP, DOGS, GUINEA PIGS - late repsonse in HUMANS differs from that in SHEEP, RABBITS, GUINEA PIGS CYSTIC FIBROSIS in HUMANS differs from genetically engineered cf/cf -/- MICE DIABETES in HUMANS differs from removal of the pancreas in DOGS, CATS EPILEPSY in HUMANS differs from the EEC pattern in MICE, MONKEYS are not "chronic models" HEART DISEASE - atherosclerosis in HUMANS differs from cholersterol-fed RABBITS - strokes in HUMANS differ from the "string grasp test" in MICE LEPROSY in HUMANS differs from the site of the lesions in ARMADILLOS MALARIA in HUMANS is caused by one of four parasites - none of which can easily be transmitted to animals SPINAL MENINGITIS in HUMANS is not contracted by RATS, GUINEA PIGS, RABBITS, MONKEYS MULTIPLE SCLEROSIS in HUMANS differs from EAE (experimental autoimmune encephalomyelitis) in RATS, GUINEA PIGS, MARMOSETS, RABBITS, MICE MUSCULAR DYSTROPHY in HUMANS differs from mdx MICE, which regenerate muscles - which humans cannot PARKINSON`S DISEASE in HUMANS differs from that induced by MPTP in MARMOSETS PNEUMONIA in HUMANS has no animal "model" for the pathological mechanisms POLIOMYELITIS in HUMANS differs from that in RABBITS, MONKEYS, CHIMPANZEES RUBELLA in HUMANS differs from that in MONKEYS SMALLPOX in HUMANS is caused by the variola virus - which has never been recovered form animals under laboratory conditions TUBERCULOSIS in HUMANS differs from that induced in GUINEA PIGS ULCERS - stomach ulcers in HUMANS differ from that in DOGS - peptic ulcers, ulcers of colon, ulcers of rectum in HUMANS do not occur in animals. |
DRUGS and MEDICINES ASPIRIN is an analgesic in HUMANS - causes birth defects in RATS, MICE, CATS, GUINEA PIGS, MONKEYS PENICILLIN is an antibiotic in HUMANS - kills GUINEA PIGS INSULIN is a treatment for diabetes in HUMANS - causes birth defects in MICE, RABBITS DIGITALIS is a treatment for heart failure in HUMANS - raises blood pressure in animals CHLOROFORM is an anaesthetic in HUMANS - fatal in DOGS, causes liver damage in MICE, causes birth defects in RATS AZAURIDINE is a cancer treatment in HUMANS - fatal in DOGS PREDNISONE is a treatment for leukaemia in HUMANS - useless against a range of animal tumours including two types of leukamia |
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