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Andrographis extract, 300mg, 60 capsules |
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As a dietary supplement,
take two capsules one or two times daily with meals or a glass of
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Andrographis (Andrographis
paniculata) (aerial extract) (Guaranteed 24 mg [4%] andrographolides)
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Andrographis (Andrographis
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*** UPDATE IN PROGRESS ***
Kan Jang
Kan Jang is a nontoxic and
nondrowsy, water soluble herbal supplement, which contains no caffeine and
no alcohol, like many other cold and flu remedies.
Kan Jang - Pubmed Search
results
1: Phytomedicine. 2006
May;13(5):318-23. Epub 2005 Sep 16. The effect of Kan Jang extract on the
pharmacokinetics and pharmacodynamics of warfarin in rats. Hovhannisyan
AS, Abrahamyan H, Gabrielyan ES, Panossian AG.
Significant pharmacokinetic/pharmacodynamic
interactions between various herbal products and warfarin have recently been
reported. The aim of this study was to determine whether concomitant
treatment of rats with Kan Jang (a standardized fixed combination of
extracts from Andrographis paniculata and Eleutherococcus senticosus) and
warfarin would lead to an alteration in the pharmacological effects of
warfarin. Each day for 5 days a group of animals was treated orally with an
aqueous solution of Kan Jang at a dose of 17 mg/kg of the active principle
andrographolide (a daily dose some 17-fold higher than that recommended for
humans): the control group received similar treatment with appropriate
volumes of water only. Sixty minutes after the final daily administration of
Kan Jang or water, an aqueous solution of warfarin (0.2 mg/ml) was given to
each animal at a dose of 2 mg/kg. From each group, 6 animals were sacrificed
at 0, 2, 4, 6, 8, 12, 24, 30 and 48 h after warfarin administration and
blood samples taken. The concentration of warfarin in blood plasma was
measured by capillary electrophoresis using 50 mM borate buffer (pH 9.3) as
mobile phase with simultaneous detection of warfarin at 208.1 and 307.5 nm.
Prothrombin time in blood plasma was measured using thromboplastin reagent.
The concomitant application of Kan Jang and warfarin did not produce
significant effects on the pharmacokinetics of warfarin, and practically no
effect on its pharmacodynamics. PMID: 16635739 [PubMed - indexed for
MEDLINE]
2: Phytomedicine. 2005
Jun;12(6-7):403-9. A phase I clinical study of Andrographis paniculata
fixed combination Kan Jang versus ginseng and valerian on the semen quality
of healthy male subjects. Mkrtchyan A, Panosyan V, Panossian A, Wikman
G, Wagner H.
The safety of different doses
of Kan Jang--a fixed combination of Andrographis paniculata special extract
(SHA-10) and Acanthopanax senticosus--compared to two extensively used
medicinal plants, Valeriana officinalis and Panax ginseng in the form of
standardized extracts, has been examined. A phase I clinical study was
designed to evaluate the effect on semen quality of healthy males in terms
of spermatogenesis and quality of semen. The results of the study revealed
no significant negative effect of Kan Jang on male semen quality and
fertility, but rather a positive trend with respect to the number of
spermatozoids in the whole ejaculate, the percentage of active (normokinetic)
forms of spermatozoids, and fertility indexes, together with a decrease in
the percentage of inactive (diskinetic) forms of spermatozoids. In the group
receiving ginseng, no significant negative effects on the fertility
parameters were revealed and there was a clear decrease in the percentage of
diskinetic forms of spermatozoids. Subjects receiving valerian showed a
temporary increase in the percentage of normokinetic spermatozoids and a
decrease in diskinetic forms, but these changes had no effect on fertility
indices. The results indicate that Kan Jang, ginseng and valerian are safe
with respect to effects on human male sterility when administered at dose
levels corresponding to approximately 3 times the human daily dose. PMID:
16008115 [PubMed - indexed for MEDLINE]
3: J Herb Pharmacother.
2003;3(1):77-93. A randomized, controlled study of Kan Jang versus
amantadine in the treatment of influenza in Volgograd. Kulichenko LL,
Kireyeva LV, Malyshkina EN, Wikman G.
Two randomized, parallel-group
clinical studies with a verum and a control group were performed to
investigate the effect of a standardized extract (SHA-10) of Andrographis
panaiculata (N.) fixed combination Kan Jang in the treatment of diagnosed
influenza viral infection. The pilot study was performed on 540 patients
with 71 Kan Jang-treated patients with the second phase conducted enrolling
66 patients. The differences in the duration of sick leave and frequency of
post-influenza complications indicate that the Kan Jang phytopreparation not
only contributes to quicker recovery, but also reduces the risk of
post-influenza complications. Kan Jang was well tolerated by patients. PMID:
15277072 [PubMed]
4: Phytother Res. 2004
Jan;18(1):47-53. Comparative controlled study of Andrographis paniculata
fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the
treatment of uncomplicated respiratory disease in children. Spasov AA,
Ostrovskij OV, Chernikov MV, Wikman G.
A three-arm study comparing the
efficacy of Kan Jang, a fixed herbal combination containing standardized
Andrographis paniculata (N.) SHA-10 extract, with Immunal, a preparation
containing Echinacea purpurea (L.) extract, in uncomplicated common colds
was carried out in 130 children aged between 4 and 11 years over a period of
10 days. The study was designed as an adjuvant treatment of Kan Jang and
Immunal with a standard treatment. The patients were assigned to one of the
three groups. In control group C; 39 patients received only standard
treatment. Kan Jang and Immunal were used as an adjuvant to this therapy in
the other two groups. Adjuvant group A; 53 patients treated with Kan Jang
tablets concomitant to standard treatment, and adjuvant control group B; 41
patients treated with concomitant Immunal. It was found that the adjuvant
treatment with Kan Jang, was significantly more effective than Immunal, when
started at an early stage of uncomplicated common colds. The symptoms of the
disease were less severe in the Kan Jang group. The effect of Kan Jang was
particularly pronounced in two objective parameters, amount of nasal
secretion g/day and nasal congestion. Kan Jang also accelerated the recovery
time, whereas Immunal did not show the same efficacy. The use of standard
medication was significantly less in the Kan Jang adjuvant group than in
either the Immunal or standard treatment group. Kan Jang treatment was well
tolerated and no side effects or adverse reactions were reported. Copyright
2004 John Wiley & Sons, Ltd. PMID: 14750201 [PubMed - indexed for MEDLINE]
5: Phytomedicine. 2002
Oct;9(7):598-605. Effect of andrographolide and Kan Jang--fixed
combination of extract SHA-10 and extract SHE-3--on proliferation of human
lymphocytes, production of cytokines and immune activation markers in the
whole blood cells culture. Panossian A, Davtyan T, Gukassyan N, Gukasova
G, Mamikonyan G, Gabrielian E, Wikman G.
The immunomodulatory properties
of a diterpene lactone andrographolide and Kan Jang--a standardized fixed
combination of Andrographis paniculata extract SHA-10 and Eleutherococcus
senticosus extract SHE-3 were investigated. Their role on spontaneous and
phytohemagglutinin (PHA)-induced proliferation of human peripheral blood
lymphocytes (PBL) and on production of interferon-gamma (INF-gamma) and
tumor necrosis factor-alpha (TNF-alpha) were determined in vitro.
Proliferation of PBL induced by PHA was enhanced by co stimulation with
andrographolide and Kan Jang. At the same time andrographolide and Kan Jang
inhibit spontaneous proliferation of PBL in vitro. These preparations also
have effect on the formation of INF-gamma, TNF-alpha and some immune
activation markers such as neopterin (Neo), beta-2-microglobulin (beta2MG),
and soluble receptor for interleukin-2 (sIL-2R or sCD25) in blood cells
culture. Andrographolide and Kan Jang stimulate the INF-gamma, Neopterin and
beta2MG formation, but do not have any significant effect on the production
of INF-gamma and Neopterin in PHA stimulated blood cells. An opposite effect
on these immune makers was observed in the PHA-stimulated blood cells: both
andrographolide and Kan Jang increase the formation of TNF-alpha and beta2MG
in cultivated whole blood cells. Thus, andrographolide and Kan Jang can have
an in vitro effect on the activation and proliferation of immunocompetent
cells as well on the production of key cytokines and immune activation
markers. The results show an overall higher effect of the fixed combination
as compared with the equivalent amount of the pure substance
andrographolide. The data are consistent with results from clinical studies
of Kan Jang and contributed to a better understanding of these results. PMID:
12487323 [PubMed - indexed for MEDLINE]
6: Phytomedicine. 2002
Oct;9(7):589-97. A double blind, placebo-controlled study of Andrographis
paniculata fixed combination Kan Jang in the treatment of acute upper
respiratory tract infections including sinusitis. Gabrielian ES,
Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H.
Erebuni
A double blind,
placebo-controlled, parallel-group clinical study was carried out to
evaluate the effect of an Andrographis paniculata (N.) extract SHA-10 fixed
combination, Kan Jang, in the treatment of acute upper respiratory tract
infections, including sinusitis. Ninety-five individuals in the treatment
group and 90 individuals in the placebo group completed the study according
to the protocol. The medication was taken for 5 days. Temperature, headache,
muscle aches, throat symptoms, cough, nasal symptoms, general malaise and
eye symptoms were taken as outcome measures with given scores. The total
score analysis showed a highly significant improvement in the verum group
versus the placebo. This result applied to the group as a whole and to the
sinusitis subgroups. The individual symptoms of headache and nasal and
throat symptoms together with general malaise showed the most significant
improvement while cough and eye symptoms did not differ significantly
between the groups. Temperature was moderately reduced in the verum group.
It can be concluded that Kan Jang has a positive effect in the treatment of
acute upper respiratory tract infections and also relieves the inflammatory
symptoms of sinusitis. The study drug was well tolerated. PMID: 12487322 [PubMed
- indexed for MEDLINE]
7: Mol Cells. 2002 Feb
28;13(1):21-7. Production of monoclonal antibodies and
immunohistochemical studies of brain myo-inositol monophosphate phosphatase.
Bahn JH, Kim AY, Jang SH, Lee BR, Ahn JY, Joo HM, Kan TC, Won MH, Kwon HY,
Kang JH, Kwon OS, Kim HB, Cho SW, Lee KS, Park J, Choi SY.
Five monoclonal antibodies that
recognize porcine brain myo-inositol monophosphate phosphatase (IMPase) have
been selected and designated as mAb IMPP 9, IMPP 10, IMPP 11, IMPP 15, and
IMPP 17. These antibodies recognize different epitopes of the enzyme and one
of these inhibited the enzyme activity. When the total proteins of the
porcine brain homogenate separated by SDS-PAGE were probed with monoclonal
antibodies, a single reactive protein band of 29 kDa, co-migrating with the
purified porcine brain IMPase, was detected. Using the anti-IMPase
antibodies as probes, the cross reactivities of the brain IMPase from human
and other mammalian tissues, as well as from avian sources, were
investigated. Among the human and animal tissues tested, the immunoreactive
bands on Western blots appeared to have the same molecular mass of 29 kDa.
In addition, there was IMPase immunoreactivity in the various neuronal
populations in the rat brain. These results indicate that mammalian brains
contain only one major type of immunologically similar IMPase, although some
properties of the enzymes that were previously reported differ from each
another. The first demonstration of the IMPase localization in the brain may
also provide useful data for future investigations on the function of this
enzyme in relation to various neurological diseases. PMID: 11911470 [PubMed
- indexed for MEDLINE]
8: Biochem Biophys Res Commun.
2001 May 18;283(4):791-7. Evidence that the intracellular domain of FGF
receptor 2IIIb affects contact of the ectodomain with two FGF7 ligands.
Uematsu F, Jang JH, Kan M, Wang F, Luo Y, McKeehan WL.
Models of the oligomeric FGF
signaling complex, including those derived from crystal structures, vary in
stoichiometry and arrangement of the three subunits comprised of heparin/heparan
sulfate chains, FGFR tyrosine kinase and activating FGF. Here, using
covalent affinity crosslinking of radiolabeled FGF7 to binary complexes of
FGFR2IIIb and heparin, we show that two molecules of FGF7 contact each
FGFR2IIIb. This supports models that propose a dimeric complex of two units
with stoichiometry 1 FGF:1 FGFR in which each FGF contacts both FGFR. The
bivalent FGF7 contact was dependent on the full-length amino terminus of
FGF7alpha and the intracellular domain of FGFR2IIIb extending through the
juxtamembrane domain and the beta1 and beta2 strands of the kinase which is
required for ATP binding. We propose that the differences in crosslinking
report differences in relationships among subunits in the ectodomain of the
complex that are affected by the amino terminus of FGF and the FGFR
intracellular domain. From this, we suggest the corollary that
conformational relationships among subunits in the ectodomain are
transmitted to the intracellular and ATP binding domains during activation
of the complex. PMID: 11350054 [PubMed - indexed for MEDLINE]
9: Phytomedicine. 2000
Oct;7(5):351-64. Pharmacokinetic and oral bioavailability of
andrographolide from Andrographis paniculata fixed combination Kan Jang in
rats and human. Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H,
Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H.
Validated analytical methods (HPLC,
CE and GC-MS) for determining the amount of andrographolide (AND) in the
blood plasma of rats and human volunteers following the oral administration
of Andrographis paniculata extract (APE) and Andrographis paniculata fixed
combination Kan Jang tablets were developed and used for the pharmacokinetic
study. Andrographolide was quickly and almost completely absorbed into the
blood following the oral administration of APE at a dose of 20 mg/kg body
wt. in rats. Its bio-availability, however, decreased four-fold when a
10-times-higher dose was used. Since a large part (55 %) of AND is bound to
plasma proteins and only a limited amount can enter the cells, the
pharmacokinetics of AND are described well by a one-compartment model. Renal
excretion is not the main route for eliminating AND. It is most likely
intensely and dose dependently metabolized. Following the oral
administration of four Kan Jang tablets (a single therapeutic dose, equal to
20 mg of AND) to humans, maximum plasma levels of approximately 393 ng/ml
(approx. 1.12 microM) were reached after 1.5-2 hours, as quantified using a
UV diode-array detection method. Half-life and mean residence times were 6.6
and 10.0 hours, respectively. AND pharmacokinetics in humans are explained
well by an open two-compartment model. The calculated steady state plasma
concentration of AND for multiple doses of Kan Jang (after the normal
therapeutic dose regimen, 3 x 4 tablets/day, about 1 mg AND/kg body wt./day)
was approximately 660 ng/ml (approx. 1.9 microM), enough to reveal any anti-PAF
effect, particularly after drug uptake when the concentration of AND in
blood is about 1342 ng/ml (approx. 3.8 microM, while for anti-PAF effect
EC50 - 5 microM). PMID: 11081986 [PubMed - indexed for MEDLINE]
10: Phytomedicine. 2000
Oct;7(5):341-50. Double-blind, placebo-controlled pilot and phase III
study of activity of standardized Andrographis paniculata Herba Nees extract
fixed combination (Kan jang) in the treatment of uncomplicated
upper-respiratory tract infection. Melchior J, Spasov AA, Ostrovskij OV,
Bulanov AE, Wikman G. Hallehalsan
Two randomized double-blind,
placebo-controlled parallel group clinical trials were performed to
investigate the effect of a standardized extract (SHA-10) of Andrographis
paniculata fixed combination (Kan jang) in the treatment of uncomplicated
upper-respiratory tract infections. 46 patients in the pilot study and 179
patients in the phase III study completed the study according to the
protocol. Medication was taken three times daily for a minimum of 3 days and
a maximum of 8 days for the pilot study, and for exactly three days in the
phase III study. The primary outcome measures in the patients
self-evaluation were: related to pain in the muscle, cough, throat symptoms,
headache, nasal symptoms and eye symptoms and temperature. The physician's
fixed score diagnosis was based mainly on sign/symptoms: ears, nose, oral
cavity, lymph glands-tonsils and eyes. The total symptom score showed a
tendency toward improvement in the pilot study (p = 0,08), while both the
total symptom score and total diagnosis score showed highly significant
improvement (p < or = 0.0006 resp. 0.003) in the verum group as compared
with the placebo. In both studies throat symptoms/signs, were found to show
the most significant improvement. Publication Types: Clinical Trial Clinical
Trial, Phase III Randomized Controlled Trial PMID: 11081985 [PubMed -
indexed for MEDLINE]
11: Biochem Biophys Res Commun.
2000 Jun 16;272(3):830-6. Ligand binding properties of binary complexes
of heparin and immunoglobulin-like modules of FGF receptor 2. Uematsu F,
Kan M, Wang F, Jang JH, Luo Y, McKeehan WL.
Epithelial cells, which express
FGFR2IIIb, bind and respond to FGF-1, FGF-7 and FGF-10, but not FGF-2.
Stromal cells, which bind and respond to FGF-1 and FGF-2, but not FGF-7 and
FGF-10, express FGFR2IIIc or FGFR1IIIc. Here we show that when both isolated
FGFR2betaIIIb and FGFR2betaIIIc or their common Ig module II are allowed to
affinity select heparin from a mixture, the resultant binary complexes bound
FGF-1, FGF-2, and FGF-7 with nearly equal affinity. In addition, FGF-2 and
FGF-7 bound to both heparin-Ig module IIIb and IIIc complexes, but FGF-1
bound to neither Ig module III. The results show that in isolation both Ig
modules II and III of FGFR2 can interact with heparin and that each exhibits
a binding site for FGF. We suggest that the specificity of FGFR2IIIb and
FGFR2IIIc is dependent on the cell membrane environment and heparin/heparan
sulfate. Ig modules II and III cooperate both within monomers and across
dimers with cellular heparan sulfates to confer cell type-dependent
specificity of the FGFR complex for FGF. PMID: 10860838 [PubMed - indexed
for MEDLINE]
12: Phytomedicine. 1999
Jul;6(3):157-61. Effect of Andrographis paniculata extract on
progesterone in blood plasma of pregnant rats. Panossian A, Kochikian A,
Gabrielian E, Muradian R, Stepanian H, Arsenian F, Wagner H.
The effect of the powdered
extract of Andrographis paniculata leaves (APE), an active principle of Kan
Jang tablets [standardized for content of andrographolide (4.6%) and
14-deoxo-andrographolide (2.3%) content (total andrographolids--6.9%)] on
blood progesterone content in rats was studied. Peroral administration of
APE during the first 19 days of pregnancy in doses of 200, 600, and 2000
mg/kg (i.e. doses 30, 90, and 300 fold higher than its daily therapeutic
dose in humans) does not exhibit any effect on the elevated level of
progesterone in the blood plasma of rats. Let us assume then that in
therapeutic dose, Andrographis paniculata extract cannot induce
progesterone-mediated termination of pregnancy. PMID: 10439479 [PubMed -
indexed for MEDLINE]
13: Biochemistry. 1998 Nov
24;37(47):16506-15. The glycine box: a determinant of specificity for
fibroblast growth factor. Luo Y, Lu W, Mohamedali KA, Jang JH, Jones RB,
Gabriel JL, Kan M, McKeehan WL.
Acidic fibroblast growth factor
(FGF-1), keratinocyte growth factor (FGF-7), and FGF-10 are homologues with
distinct specificity. In the presence of heparin, FGF-1 binds and activates
in vitro all FGFR subtypes, while FGF-7 exhibits absolute specificity for
the IIIb splice variant of FGFR2. FGF-10 exhibits a similar specificity but
also binds the FGFR1IIIb isoform. Neither FGF-7 nor FGF-10 will bind to IIIc
isoforms of FGFR. Molecular models of FGF, heparin, and the FGFR ectodomain
suggested that sequences between beta-strands 10 and 12 of FGF may be
important for the interaction of FGF with the heparin-FGFR ectodomain
duplex. Site-directed mutants of FGF-7 and FGF-10 were prepared to test
whether this domain might underlie failure of FGF-7 and FGF-10 to bind to
the FGFRIIIc isoforms. Constructions with substitution of FGF-1 sequences
spanning the entire C-terminus encoded in exon 3 or only C-terminal
sequences spanning beta-strands 10 through 12 conferred ability on FGF-7 to
bind to and activate FGFRIIIc without a significant loss in binding to or
activation of FGFR2IIIb. A series of twelve different substitutions of
shorter segments of FGF-1 sequences into the C-terminal portion of FGF-7 or
FGF-10 revealed that substitution of GSCKRG for GIPVRG or the tri-peptide
sequence KKN for NQK just N-terminal to it conferred dual activities on both
the FGF-7 and FGF-10 backbones. The results suggest that the combined
sequence domain, which we call the FGF glycine box (G-box), is a major
determinant for the specificity of the binding of FGF to heparan sulfate-FGFR
duplexes. PMID: 9843417 [PubMed - indexed for MEDLINE]
14: In Vitro Cell Dev Biol Anim.
1997 Nov-Dec;33(10):819-24. Heparan sulfate is required for interaction
and activation of the epithelial cell fibroblast growth factor
receptor-2IIIb with stromal-derived fibroblast growth factor-7. Jang JH,
Wang F, Kan M.
Fibroblast growth factor-7
(FGF-7) and a specific splice variant of the FGF tyrosine kinase receptor
family (FGFR2IIIb) constitute a paracrine signaling system from stroma to
epithelium. Different effects of the manipulation of cellular heparan
sulfates and heparin on activities of FGF-7 relative to FGF-1 in epithelial
cells suggest that pericellular heparan sulfates may regulate the activity
of FGF-7 by a different mechanism than other FGFs. In this report, we employ
the heparan sulfate-binding protein, protamine sulfate, to reversibly block
cellular heparan sulfates. Protamine sulfate, which does not bind
significantly to FGF-7 or FGFR2IIIb, inhibited FGF-7 activities, but not
those of epidermal growth factor. The inhibition was overcome by increasing
the concentrations of FGF-7 or heparin. Heparin was essential for binding of
FGF-7 to recombinant FGFR2IIIb expressed in insect cells or FGFR2IIIb
purified away from cell products. These results suggest that, similar to
other FGF polypeptides, heparan sulfate within the pericellular matrix is
required for activity of FGF-7. Differences in response to heparin and
alterations in the BULK heparan sulfate content of cells likely reflect FGF-specific
differences in the cellular repertoire of multivalent heparan sulfate chains
required for assembly and activation of the FGF signal transduction complex.
PMID: 9466688 [PubMed - indexed for MEDLINE]
15: In Vitro Cell Dev Biol Anim.
1997 Nov-Dec;33(10):727-30. High salt inhibits both heparin-dependent and
heparin-independent complexes of fibroblast growth factor and the receptor
kinase.
No abstract. PMID: 9466672 [PubMed
- indexed for MEDLINE]
16: J Biol Chem. 1997 Sep
19;272(38):23887-95. A homeo-interaction sequence in the ectodomain of
the fibroblast growth factor receptor. Wang F, Kan M, McKeehan K, Jang
JH, Feng S, McKeehan WL.
Interaction of fibroblast
growth factor receptors (FGFR) sufficient for a trans-phosphorylation event
in which one intracellular domain is substrate for the other is essential
for signal transduction. By analysis of the direct interaction of
recombinant constructions co-expressed in baculoviral-infected insect cells,
we identified a 17-amino acid sequence that is required for the stable
interaction between ectodomains of FGFR. The sequence
160ERSPHRPILQAGLPANK176 (Glu160-Lys176) connects immunoglobulin modules II
and III. In insect cells, the interaction between Glu160-Lys176 domains
occurs independently of intact heparin or FGF binding domains. The sequence
is not required for the binding of heparin or FGF-1, but is essential for
mitogenic activity of the FGFR kinase in mammalian cells. The results
support a model in which the homeo-interaction between Glu160-Lys176 in the
ectodomain contributes to the interaction between intracellular domains in
mammalian cell membranes (Kan, M., Wang, F., Kan, M., To, B., Gabriel, J.
L., and McKeehan, W. L. (1996) J. Biol. Chem. 271, 26143-26148). We propose
that the Glu160-Lys176 domain plays a pivotal role in restriction of the
interaction between kinases by pericellular matrix heparan sulfate
proteoglycan and divalent cations. Restrictions are overcome by FGF or
constitutively by diverse gain of function mutations which cause skeletal
and craniofacial abnormalities. PMID: 9295338 [PubMed - indexed for MEDLINE]
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