Table 4

Study 205

 Mean (X) and Mean Change (∆) from Baseline in 28-item HAMD

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

34.3

107

-4.2

112

-7.3

112

-10.0

112

-12.0

112

-13.4

112

-14.1

112

-14.8

112

-15.6

BUP SR 200 (L)

114

33.5

106

-4.7

114

-6.8

114

-9.1

114

-10.8

114

-11.9

114

-13.2

114

-13.7

114

-14.0

BUP SR 300 (M)

111

34.1

106

-5.0

111

-7.5

111

-9.3

111

-11.0

111

-11.8

111

-12.6

111

-13.3

111

-13.4

BUP SR 400 (II)

111

35.1

108

-3.4

111

-6.9

111

-9.3

111

-11.4

111

-11.7

111

-12.4

111

-13.1

111

-14.1

Placebo (P)

116

33.5

109

-4.2

116

-6.7

116

-8.0

116

-9.8

116

-10.5

116

-12.2

116

-11.4

116

-11.9

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.2

0.88

0.58

0.10

0.085

0.033

0.043

0.021

0.018

L vs. P

> 0.5

0.62

0.97

0.39

0.44

0.32

0.17

0.12

0.18

M vs. P

> 0.5

.034

0.48

0.31

0.38

0.40

0.38

0.24

0.39

II vs. P

> 0.05

0.34

0.48

0.31

0.38

0.40

0.38

0.24

0.39

OBSERVED CASES ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

34.3

107

-4.2

103

-7.5

102

-10.6

89

-12.9

85

-14.5

86

-16.2

82

-17.1

76

-18.1

BUP SR 200 (L)

114

33.5

106

-4.7

100

-7.4

95

-9.6

90

-11.8

85

-13.4

83

-15.4

80

-16.5

74

-16.5

BUP SR 300 (M)

111

34.1

106

-5.0

98

-8.0

81

-11.1

80

-13.6

77

-15.0

71

-17.1

69

-17.9

66

-18.5

BUP SR 400 (II)

111

35.1

108

-3.4

94

-7.9

88

-10.4

83

-13.4

77

-14.3

75

-15.4

72

-16.8

70

-18.0

Placebo (P)

116

33.5

109

-4.2

107

-6.9

102

-8.6

90

-11.3

87

-12.6

83

-13.7

82

-13.7

75

-14.9

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.2

0.88

0.50

0.086

0.23

0.19

0.093

0.052

0.086

L vs. P

> 0.5

0.62

0.57

0.37

0.74

0.59

0.22

0.087

0.40

M vs. P

> 0.5

0.34

0.25

0.038

0.078

0.11

0.026

0.015

0.032

II vs. P

> 0.05

0.26

0.28

0.093

0.08

0.20

0.17

0.045

0.036