Table 5

Study 205: Mean (X) and Mean Change (∆) from Baseline in HAMD Depressed Mood Item #1

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

2.8

107

-0.3

112

-0.6

112

-0.8

112

-1.0

112

-1.1

112

-1.2

112

-1.2

112

-1.2

BUP SR 200 (L)

114

2.7

106

-0.3

114

-0.5

114

-0.7

114

-0.8

114

-0.9

114

-1.0

114

-1.0

114

-1.1

BUP SR 300 (M)

111

2.8

106

-0.4

111

-0.5

111

-0.7

111

-0.8

111

-0.9

111

-0.9

111

-1.0

111

-1.0

BUP SR 400 (II)

111

2.8

108

-0.2

111

-0.6

111

-0.7

111

-1.0

111

-1.0

111

-1.0

111

-1.0

111

-1.2

Placebo (P)

116

2.9

109

-0.3

116

-0.6

116

-0.7

116

-0.8

116

-0.9

116

-0.9

116

-1.0

116

-1.0

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.05

0.9

0.9

0.4

0.2

0.1

0.04

0.1

0.2

L vs. P

< 0.005

0.8

0.1

0.9

0.8

1.0

0.4

0.8

0.6

M vs. P

> 0.05

0.7

0.4

0.8

0.7

0.8

0.9

0.9

0.8

II vs. P

> 0.1

0.2

0.6

0.6

0.1

0.2

0.4

0.6

0.3

OBSERVED CASES ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

2.8

107

-0.3

103

-0.6

102

-0.8

89

-1.0

85

-1.2

86

-1.3

82

01.4

76

-1.4

BUP SR 200 (L)

114

2.7

106

-0.3

100

-0.5

95

-0.7

90

-0.8

85

-1.0

83

-1.1

80

-1.2

74

-1.2

BUP SR 300 (M)

111

2.8

106

-0.4

98

-0.6

81

-0.9

80

-1.1

77

-1.1

71

-1.2

69

-1.3

66

-1.3

BUP SR 400 (II)

111

2.8

108

-0.2

94

-0.6

88

-0.8

83

-1.1

77

-1.2

75

-1.3

72

-1.4

70

-1.6

Placebo (P)

116

2.9

109

-0.3

107

-0.6

102

-0.7

90

-1.0

87

-1.1

83

-1.1

82

-1.2

75

-1.3

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.05

0.9

0.8

0.2

0.5

0.7

0.2

0.3

0.3

L vs. P

< 0.005

0.8

0.2

0.7

0.3

0.3

0.8

0.9

0.7

M vs. P

> 0.05

0.7

0.7

0.1

0.2

0.8

0.6

0.6

0.7

II vs. P

> 0.1

0.2

0.9

0.2

0.07

0.2

0.1

0.2

0.05