Table 3

Study 205

 Mean (X) and Mean Change (∆) from Baseline in 17-item HAMD

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

23.6

107

-2.9

112

-5.0

112

-6.8

112

-8.2

112

-9.1

112

-9.7

112

-10.0

112

-10.5

BUP SR 200 (L)

114

23.2

106

-3.0

114

-4.3

114

-6.1

114

-7.2

114

-8.0

114

-9.0

114

-9.3

114

-9.6

BUP SR 300 (M)

111

23.6

106

-3.2

111

-4.9

111

-6.3

111

-7.6

111

-8.0

111

-8.5

111

-8.9

111

-9.0

BUP SR 400 (II)

111

24.2

108

-1.9

111

-4.2

111

06.1

111

-7.4

111

-7.8

111

-8.3

111

-8.8

111

-9.3

Placebo (P)

116

23.4

109

-3.1

116

-4.8

116

-5.6

116

-6.8

116

-7.4

116

-8.0

116

-7.9

116

-8.3

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.5

0.59

0.84

0.12

0.10

0.061

0.082

0.042

0.035

L vs. P

> 0.5

0.81

0.46

0.51

0.61

0.52

0.29

0.18

0.22

M vs. P

> 0.5

0.96

0.91

0.44

0.39

0.57

0.66

0.42

0.53

II vs. P

> 0.05

0.018

0.34

0.50

0.47

0.64

0.74

0.41

0.30

OBSERVED CASES ANALYSIS

Treatment Week:

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

Treatment Groups

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 100 (VL)

112

23.6

107

-2.9

103

-5.1

102

-7.2

89

-8.8

85

-9.9

86

-11.1

82

-11.5

76

-12.1

BUP SR 200 (L)

114

23.2

106

-3.0

100

-4.7

95

-6.6

90

-7.8

85

-9.0

83

-10.4

80

-11.1

74

-11.1

BUP SR 300 (M)

111

23.6

106

-3.2

98

-5.3

81

-7.4

80

-9.4

77

-10.2

71

-11.5

69

-11.9

66

-12.2

BUP SR 400 (II)

111

24.2

108

-1.9

94

-4.8

88

-7.2

83

-9.0

77

-9.8

75

-10.8

72

-11.6

70

-12.2

Placebo (P)

116

23.4

109

-3.1

107

-4.9

102

-5.9

90

-7.9

87

-8.8

83

-9.7

82

-9.5

75

-10.2

VL. vs P

2-sided

p-values

for

pairwise

compar-

isons

> 0.5

0.59

0.71

0.083

0.24

0.30

0.18

0.075

0.10

L vs. P

> 0.5

0.81

0.74

0.32

0.90

0.82

0.41

0.12

0.41

M vs. P

> 0.5

0.96

0.59

0.049

0.075

0.18

0.095

0.047

0.062

II vs. P

> 0.05

0.018

0.99

0.064

0.14

0.27

0.22

0.034

0.037