Table 6

Study 203

Mean (X) and Mean Change (∆) from Baseline in CGI-S

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 150 (L)

120

4.4

113

-0.2

120

-0.6

120

-0.9

120

-1.1

120

-1.2

120

-1.2

120

-1.3

120

-1.4

BUP SR 300 (II)

113

4.4

113

-0.2

113

-0.5

113

-0.8

113

-0.9

113

-1.0

113

-1.2

113

-1.2

113

-1.4

Placebo (P)

117

4.4

116

-0.2

117

-0.4

117

-0.6

117

-0.7

117

-0.8

117

-0.9

117

-0.9

117

-1.0

2-sided p-values for pairwise comparisons

I. vs. P

>0.5

1.0

0.09

0.02

0.002

0.02

0.05

0.007

0.03

II vs. P

>0.5

0.8

0.4

0.07

0.1

0.1

0.04

0.07

0.04

OBSERVED CASES ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 150 (L)

120

4.4

113

-0.2

109

-0.6

98

-1.0

89

-1.4

83

-1.4

70

-1.6

67

-1.8

64

-1.9

BUP SR 300 (II)

113

4.4

113

-0.2

100

-0.5

98

-0.9

87

-1.1

77

-1.2

74

-1.6

69

-1.6

62

-2.0

Placebo (P)

117

4.4

116

-0.2

112

-0.4

102

-0.7

91

-0.9

75

-1.1

69

-1.4

64

-1.5

56

-1.7

2-sided p-values for pairwise comparisons

I. vs. P

>0.5

1.0

0.05

0.03

0.002

0.02

0.4

0.1

0.3

II vs. P

>0.5

0.8

0.3

0.1

0.2

0.3

0.3

0.4

0.2