Table 5

Study 203

Mean (X) and Mean Change (∆) from Baseline in HAMD Depressed Mood Item #1

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 150 (L)

120

2.8

11.3

-0.3

120

-0.7

120

-0.9

120

-1.0

120

-1.1

120

-1.2

120

-1.2

120

-1.2

BUP SR 300 (II)

113

2.9

113

-0.4

113

-0.6

113

-0.9

113

-0.1

113

-1.1

113

-1.2

113

-1.2

113

-1.3

Placebo (P)

117

2.9

116

-0.3

117

-0.6

117

-0.7

117

-0.8

117

-0.9

117

-0.9

117

-0.9

117

-1.0

2-sided p-values for pairwise comparisons

I. vs. P

>0.5

0.9

0.5

0.2

0.1

0.2

0.06

0.03

0.08

II vs. P

>0.5

0.2

1.0

0.1

0.2

0.2

0.06

0.08

0.04

OBSERVED CASES ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

N

∆

BUP SR 150 (L)

120

2.8

113

-0.3

109

-0.7

98

-0.9

89

-1.2

83

-1.3

70

-1.5

67

-1.7

64

-1.7

BUP SR 300 (II)

113

2.9

113

-0.4

100

-0.6

98

-1.0

87

-1.1

77

-1.4

74

-1.6

69

-1.6

62

-1.9

Placebo (P)

117

2.9

116

-0.3

112

-0.6

102

-0.8

91

-1.0

75

-1.2

69

-1.4

64

-1.5

56

-1.6

2-sided p-values for pairwise comparisons

I. vs. P

>0.5

0.9

0.6

0.3

0.2

0.3

0.6

0.4

0.6

II vs. P

>0.5

0.2

1.0

0.1

0.2

0.2

0.5

0.6

0.3