|
NDA
20-358 |
5 |
9)
Organ
weights
a)
Liver
Absolute and relative weights increased at all doses, D-R. (Mean rel. wt. in HD groups approx 1.4 x control. No clear overall difference between HD and
HD*). Increase still seen after
recovery period (except at LD); the increase in F after recovery period was
slightly smaller than that seen at termination, but N too small to conclude
this confidently.
b)
Thyroid
Slight increase in abs. and rel. wt in both HD M
groups. (The effect at HD* was
equivocally greater than that at HD; mean rel. wt. 1.29 and 1.13 x control,
resp). No clear effect after recovery,
but note small N.
c)
Adrenal
Slight increase in abs. and rel. wt in both HD M
groups (Mean rel. wt. approx. 1.3 x control; no clear difference between HD and
HD*). No clear effect after recover,
but note small N.
d)
Kidney
Abs. and rel. wt. equivocally and slightly (mean
rel. wt. about 1.2 x control) increased in MD M and HD M groups; not D-R;
equivocal increases also seen after recovery.
10)
Gross
pathology
No drug effects
11)
Microscopic
pathology
(Routine exam done in controls and both HD groups at termination, and in all animals which died or were prematurely sacrificed. Among recovery animals, only male kidney, in the control and both HD groups only, was examined.
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