The
incidence of mortality for all groups is summarized as follows:
|
Dose |
N |
Number of Dead |
|
|
(mg/kg/day) |
(M/F) |
Male |
Female |
|
0 |
14/14 |
0 |
1 |
|
75a |
26/26 |
3 |
0 |
|
150a |
26/26 |
0 |
1 |
|
300a |
26/26 |
3 |
1 |
|
300 |
26/26 |
5 |
7 |
a
degraded
323U66 HCl
N =
Number
The
cause of death was determined on the basis of the gross and/or histopathologic
findings and is summarized in the chart below:
|
Group/ Sex |
Dose (mg/kg/day) |
Animal Number |
Day of Death |
Cause of Death |
|
2M |
75a |
93-6040 |
7 |
Dosing
Accident |
|
|
|
93-6044 |
33 |
Dosing
Accident |
|
4M |
300a |
93-7070 |
6 |
Undetermined |
|
|
|
93-7077 |
7 |
Undetermined |
|
5M |
300 |
93-6088 |
36 |
Undetermined |
|
|
|
93-6093 |
35 |
Dosing
Accident |
|
|
|
93-6144 |
58 |
Dosing
Accident |
|
6M |
75a |
93-6105 |
62 |
Dosing
Accident |
|
8M |
300a |
93-6125 |
15 |
Dosing
Accident |
|
9M |
300 |
93-6137 |
63 |
Dosing
Accident |
|
|
|
93-6140 |
39 |
Dosing
Accident |
|
1F |
0 |
93-6156 |
38 |
Dosing
Accident |
|
3F |
150a |
93-6182 |
35 |
Undetermined |
|
4F |
300a |
93-6195 |
48 |
Bleeding
stomach ulcers |
|
5F |
300 |
93-6206 |
40 |
Dosing
Accident |
|
|
|
93-6208 |
39 |
Dosing
Accident |
|
|
|
93-6216 |
86 |
Dosing
Accident |
|
|
|
93-6217 |
40 |
Dosing
Accident |
|
9F |
300 |
93-6262 |
40 |
Dosing
Accident |
|
|
|
93-6263 |
43 |
Dosing
Accident |
|
|
|
93-6264 |
56 |
Dosing
Accident |
aDegraded 323U66HCl
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