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NAFLD AND NASH Linked To Metabolic Syndrome And Cardiovascular Disease |
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NAFLD AND NASH Linked To Metabolic Syndrome And Cardiovascular Disease![]() Data presented at today's sessions of the 43rd Annual Meeting of European Association for Study of Liver ( EASL ) further confirm that nonalcoholic fatty liver disease ( NAFLD ) and its most severe form, nonalcoholic steatohepatitis ( NASH ) , are associated with metabolic syndrome and pose an increased risk of cardiovascular disease. NAFLD and NASH are significant health problems that affect millions of people worldwide, especially in Western countries. NAFLD is a fatty accumulation in liver that doesn't result from excessive use of alcohol. When this condition progresses, and is associated with inflammation and liver damage, it is then called NASH, which is thought to occur in 15% to 25% of cases of NAFLD. NASH is clearly associated with risk of developing liver cirrhosis, and its complications, including hepatocellular carcinoma, the most frequent primary tumour of liver. NASH-related cirrhosis is an increasingly occurring indication for liver transplantation. In turn, metabolic syndrome is a combination of risk factors, including high blood lipids, abdominal obesity, and a tendency to diabetes. The association between NAFLD, NASH, and metabolic syndrome is a great cause for concern because people with metabolic syndrome are at increased risk for type 2 diabetes and cardiovascular disease, including heart attack and stroke. According to Doctor Fabio Marra, Associate Professor of Medicine at University of Florence, " When I see a patient with a fatty liver, I have to consider all other risk factors for cardiovascular diseases and try to intervene aggressively to limit effects of those other factors, because accumulating data indicate that fatty liver may be itself an additional risk factor. ' The precise prevalence of NAFLD and NASH within individual countries is elusive. Large scale epidemiological studies are still needed, and definitive laboratory tests to identify patients with NASH are unavailable. At present, a biopsy of liver is only accepted diagnostic method. Despite these limitations, best current estimates suggest that in the general population NAFLD can be found in one-fourth to one-third of adults in Western countries. One U. S. study of children who died as a result of accidents found that 13% had NAFLD. While a number of risk factors have been identified, foregoing percentages rise most dramatically among people who are obese. For example, studies have found NAFLD in 84% to 96% of patients undergoing bariatric surgery. For these reasons, NAFLD and NASH are seen to be increasing as poor dietary habits and sedentary lifestyles become more widespread. Although NAFLD and NASH haven't to date been included as components of metabolic syndrome, increasingly onset of NAFLD is being viewed by experts as an early event in development of insulin resistance and therefore as an indicator or predictor of future metabolic syndrome. Among key unanswered questions: Why do some people with NAFLD live out their lives unaffected by their condition of having a fatty liver, while others go on to develop NASH and cirrhosis, or diabetes and/or cardiovascular disease? At present, there are no specific therapies for NASH. Among chief recommendations offered to patients are to lose weight gradually ( particularly if one is obese ) and to increase physical activity, to eat a healthy diet, and to avoid alcohol. About EASL The European Association for the Study of Liver ( EASL ) aims to promote investigation into liver disease and improve treatments that currently exist for these conditions. The association, through its annual meetings, seeks to inform and educate both scientific community as well as society in general about increasing occurrence of liver diseases along with importance of understanding these conditions in order to treat and prevent them. Since its creation in 1966, EASL congress has been hosted in 20 different European countries. Currently association has over 1400 members and the annual congress attracts over 6000 delegates from over 65 countries each year. European Association for Study of Liver http: //www. easl. ch Affordable prices for teeth porcelain laminates at Prague, Czech republic dental clinic |
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