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Circumcision Not Associated With Reduced Risk Of HIV For Men Who Have Sex With Men Science News Share   Blog   Cite Print   Email   Bookmark Circumcision Not Associated With Reduced Risk Of HIV For Men Who Have Sex With Men ScienceDaily (Oct. 14, 2008) — An Hot Virus Testing In Urban Areas analysis of previous research indicates there is a lack of sufficient evidence that circumcision reduces the risk of human immunodeficiency virus (HIV) infection or other sexually transmitted infections among men who have sex with men, according to a new article. See Can Facs See Virus also: Health & Medicine HIV and AIDS Infectious Diseases Sexual Health Mind & Brain Gender Difference Racial Issues Behavior Reference Trichomoniasis Sexually transmitted disease Transmission (medicine) Urology Randomized controlled trials (RCTs) conducted with men in Africa have shown that male circumcision reduces the likelihood of female-to-male transmission of HIV infection by 50 percent to 60 percent. Studies also suggest that male circumcision may protect heterosexual men against other sexually transmitted infections (STI), such as syphilis or chlamydial infection, according to background information in the article. Less is known about whether circumcision provides protection against HIV infection among men who have sex with men (MSM). Gregorio A. Millett, M.P.H., of the Centers for Disease Control and Prevention, Atlanta, and colleagues performed a meta-analysis of 15 studies to examine the association of circumcision status with HIV infection and other STIs among MSM. The studies included a total of 53,567 MSM participants (52 percent of whom were circumcised). The researchers found that the odds of being HIV-positive were nonsignificantly lower among MSM who were circumcised than uncircumcised. In contrast, a statistically significant protective association of circumcision with HIV infection was found for MSM studies conducted prior to the introduction of highly active antiretroviral therapy (HAART) in 1996. Of studies conducted after HAART, the association of circumcision and HIV infection was not statistically significant. "A possible explanation for [these differences] may be related to an increase in the sexual risk behaviors of MSM after HAART. It has been well documented that beliefs that HAART limits HIV transmissibility are associated with increases in sexual risk behavior among MSM, and that the era since the advent of HAART has been defined by higher rates of sexual risk behaviors among MSM, outbreaks of STIs, and increasing rates of HIV infection," the authors write. Among MSM who primarily engaged in insertive anal sex, the association between male circumcision and HIV was protective but not statistically significant. The STI analyses similarly revealed no statistically significant association by circumcision status among MSM. "Taken together, these findings indicate insufficient evidence among available observational studies conducted with MSM of an association between circumcision and HIV infection or other STIs," the researchers write. "Additional studies are necessary to elucidate further the relationship between circumcision status and HIV infection or STIs among MSM." Editorial: Circumcision and HIV Prevention Among Men Who Have Sex With Men - No Final Word In an accompanying editorial, Sten H. Vermund, M.D., Ph.D., and Han-Zhu Qian, M.D., Ph.D., of Vanderbilt University School of Medicine, Nashville, Tenn., write that only future research can answer whether MSM should be circumcised to reduce their HIV risk. "The meta-analysis by Millett et al is likely to be used by both advocates and detractors of clinical trial investment; some will argue the benefit is Facs Of Virus likely to be too modest to justify a multimillion dollar clinical trial while others will argue that only a clinical trial will answer this important HIV Virus Tool Ratings prevention question. Barriers to circumcision among heterosexual men gi virus babies include human rights issues, ethical and legal issues, high cost, fear of pain, safety concerns, availability of surgery services, and sexual risk compensation if men overrate their degree of protection and ongoing risk. As in other HIV prevention trials, circumcision would likely be insufficiently efficient to be universally effective in reducing HIV risk, and will have to be combined with other prevention modalities to have a substantial and sustained prevention effect." Adapted from materials provided by JAMA and Archives Journals. Need to cite this story in your essay, paper, or report? Use one of the following formats: APA MLA   Related Stories Circumcision Safe In Both HIV-infected And HIV-uninfected Men, Study Finds (June 4, 2008) — Adult circumcision is safe in HIV-infected men without advanced HIV disease, according to research in PLoS Medicine. Analyzing results of two clinical trials of circumcision in the rural Rakai ...  > read more Should Adult Male Circumcision Be Recommended For HIV how is papolidema virus transmitted Prevention In The US? (July 26, 2007) — Three clinical trials in Africa found that adult male circumcision Virus Kills Motherboard reduced the risk of men acquiring HIV infection from heterosexual sex by 51-60 percent. While adult male circumcision may also have ...  > read more 1 In 3 HIV Positive Gay Men Report Unprotected Sex (May cih virus 1, 2007) — More than one in three HIV positive gay men say they have unprotected sex, reveals a community survey, published in the journal Sexually Transmitted Infections. And almost one in five HIV negative ...  > read more Different HIV Rates Among Gay Men And Straight People Not Fully Explained By Sexual Behavior (Sep. 14, 2007) — Differences in sexual behaviors do not fully explain why the US HIV epidemic affects gay men so much more than straight men and women, claims research published in the journal Sexually Transmitted ...  > read more Circumcision: A Proven Strategy To Prevent HIV, Study Shows (Feb. 23, 2007) — Male circumcision Hemagglutinin Protein In Virus significantly reduces the risk of acquiring HIV in young African men, according to a University of Illinois at Chicago study published in the Feb. 24 issue of the ...  > read more Search ScienceDaily Number of stories in archives: 44,032 Find with keyword(s):   Enter a keyword or phrase to search ScienceDaily's archives for related news anti virus review topics, the latest news stories, reference articles, science videos, images, and books.   Just In: Ghostly Glow Reveals Colliding Galaxy Clusters Movement Restored To Paralyzed Limbs In Monkeys Evolution From Fish To Land Animals Revealed Magellanic Group And Its Seven Dwarf Galaxies Violently Variable Black Holes Probed People With Autism Make More Rational Decisions Human TB Found In 9,000 Year-old Skeletons Challenge To Discover Antarctica�s Hidden World   Science peripheral nerves virus Video News Men Are From Mars Functional magnetic resonance imaging of men and women under stress showed neuroscientists how their brains differed in response to stressful. ...  > full story Cancer Biologists Develop More Accurate Blood Test for Prostate Cancer Computer Scientists Develop Portable Evidence-Gathering Tool Pediatricians Reduce Ear Infections By anti virus software review Vaccinating Children more science videos Breaking News ... from NewsDaily.com "Walking fish" reveals fresh evolutionary insights Device helps monkeys move paralyzed wrists Study finds brain chemical linked to grief Ancient bones show tuberculosis older than thought Workout for brain just a few clicks away more science news In Other News ... 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