The results of the present study emphasize how diets can influence both quantitative and qualitative changes in LDL. We have shown that reducing dietary SFA and total fat decrease plasma TC and LDL - C levels and changes particle composition, resulting in beneficial changes in oxidative susceptibility. These changes may decrease the atherogenicity of LDL. Our findings also reveal that even when LDL - C levels were low in individuals who consumed the AAD that these particles still were qualitatively different and more susceptible to oxidative modification than were particles from subjects when they consumed the lower fat diets. Because of this, it will be important to conduct further studies to gain a better perspective about how lowering LDL by diet affects in vivo oxidation status of the particle and its uptake by macrophages in the artery wall. Nonetheless, the results of the present study clearly indicate that a diet high in total fat and SFA has potentially adverse effects on circulating LDL via both quantitative changes.

References: 

Brown, M.S. and Goldstein, J.L. (1983). Lipoprotein metabolism in the macrophage: 

           Implication for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 

           52 : 223-261. 

Champe, P.C. and Harvey, R.A. : Lippincott's Illustrated Reviews : Biochemistry. 2nd 

          Ed., 1994. 

Devlin, T.M. : Textbook of Biochemistry. 3rd Ed. 

Hauser, S.L., et al : Harrison's Principles of Internal Medicine. 15th Ed., 2001.

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Table of Contents  Introduction  Saturated Fat  Biosynthesis of Saturated Fatty Acids  LDL Cholesthero  Role of Oxidized LDL in Plaque Formation in Arterial Wall  Fat Intake  Reducing Cholesterol