Multi-State Route Descriptions
Route 500 (Daytona Beach, FL to Indianapolis, IN)
FLORIDA--Daytona Beach, St. Augustine, Jacksonville
GEORGIA--Brunswick, Savannah
SOUTH CAROLINA--Beaufort, Charleston, Florence, Darlington, Cheraw
NORTH CAROLINA--Rockingham, Asheboro, Greensboro
VIRGINIA--Martinsville, Roanoke, Blacksburg
WEST VIRGINIA--Princeton, Beckley, Charleston, Ripley
OHIO--Athens, Lancaster, Columbus, Springfield, Dayton
INDIANA--Richmond, Indianapolis
Route 555 (Los Angeles, CA to New York, NY)
CALIFORNIA--Los Angeles, San Bernardino, Palm Springs
ARIZONA--Phoenix, Casa Grande, Tucson
NEW MEXICO--Lordsburg, Las Cruces
TEXAS--El Paso, San Antonio, Houston, Lufkin, Tyler, Sulphur Springs, Paris
OKLAHOMA--Hugo, McAlester, Okmulgee, Tulsa, Miami
MISSOURI--Joplin, Springfield, St. Louis
ILLINOIS--East St. Louis, Vandalia, Effingham
INDIANA--Terre Haute, Indianapolis, Anderson, Fort Wayne
OHIO--Van Wert, Findlay, Tiffin, Willard, Akron, Youngstown
PENNSYLVANIA--New Castle, Pittsburgh, Monroeville, Altoona, State College, Stroudsburg, East Stroudsburg
NEW JERSEY--Parsippany, Orange, Newark, Jersey City
NEW YORK--New York (Manhattan/Brooklyn)
Route 666 (Sacramento, CA to Lansing, MI)
CALIFORNIA--Sacramento, Placerville, Topaz, Crestview, Bishop, Lone Pine, Keeler, Death Valley, Death Valley Jct., Shoshone, Tecopa, Mountain Pass, Nipton
NEVADA--Searchlight, Laughlin
ARIZONA--Bullhead City, Kingman, Wickendale, Glendale, Phoenix, Tempe, Mesa
NEW MEXICO--Lordsburg, Las Cruces, Alamogordo, Roswell
TEXAS--Brownfield, Lubbock, Seymour, Jacksboro, Fort Worth, Irving, Dallas, Athens, Jacksonville, Lufkin, Jasper
LOUISIANA--DeRidder, Lake Charles, Lafayette, New Iberia, Morgan City, Houma, Marrero, New Orleans, Alton
MISSISSIPPI--Picayune, Hattiesburg, Meridian, Columbus, Tupelo, Booneville, Corinth
TENNESSEE--Savannah, Lawrenceburg, Columbia, Nashville
KENTUCKY--Franklin, Bowling Green, Elizabethtown, Louisville, Florence, Covington
OHIO--Cincinnati, Dunlap, Hamilton, Middletown, Dayton, Troy, Lima, Findlay, Bowling Green, Toledo
MICHIGAN--Ann Arbor, Dexter, Hell, Gregory, Millville, Dansville, Mason, Lansing
Route 777 (Las Vegas, NV to Atlantic City, NJ)
NEVADA--Las Vegas, Moapa, Glendale, Mesquite
UTAH--St. George, Cedar City, Cove Fort, Richfield
COLORADO--Grand Junction, Denver, Fort Morgan, Brush, Sterling
NEBRASKA--North Platte, Lincoln, Omaha
IOWA--Council Bluffs, Des Moines, Iowa City, Davenport, Bettendorf
ILLINOIS--Rock Island, Moline, Rock Falls, Rochelle, DeKalb, Aurora, Naperville, Chicago
INDIANA--Hammond, East Chicago, Gary, Portage, Michigan City, South Bend, Elkhart
OHIO--Toledo, Port Clinton, Sandusky, Cleveland, Warren, Youngstown
PENNSYLVANIA--Plum, Monroeville, Somerset, Bedford, Breezewood, Harrisburg, Hershey, Lebanon, Reading, Pottstown, Norristown, Philadelphia
NEW JERSEY--Camden, Cherry Hill, Hammonton, Atlantic City
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NOTES:
The number
500 is appropriate for a highway that connects Daytona Beach to Indianapolis.  In addition, it goes through the racing towns of Darlington and Martinsville, as well as Level Cross, North Carolina (the home of NASCAR racing legend Richard Petty!).

The number
555 is my number of choice for a New York-to-L.A. route, because those numbers are always the first three digits in fictional telephone numbers.  Thank Hollywood for that.

The number
666 is my number of choice for a highway that goes through Death Valley, California and Hell, Michigan.  In addition, it also goes through the Dallas-Ft. Worth metropolis, which is home to the most hated team in all of professional sports, the NFL's Dallas Cowboys.

The number
777 is appropriate for a highway that connects Las Vegas to Atlantic City via Chicago.  All three cities have been known as meccas for casino-goers.
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