Pharmacology of Antimicrobials and Cytotoxic drugs
21. Aminoglycosides:
a. T: formed inactive complexes with penicillins in vitro.
b. F: poor oral bioavailability, have to be give parenterally.
c. T
d. T
22. Aspirin increases methotrexate toxicity:
a. T
b. T
c. F
d. F
23. 6-mercaptopurine:
a. F: is a structural analogue of hypoxanthine; it is converted by HGPRT to a ribonucleotide monophosphate which is incorporated into cellular DNA and interfere with transcription.
b. F: inhibits enzymes involved in purine interconversions which in turn inhibits DNA synthesis.
c. T: used to treat acute leukaemias in children - usually as maintenance therapy for patients in remission.
d. F
24. The alkylating agent:
a. T
b. T
c. T
d. T: causes tissue necrosis.
25. Tetracycline absorption may be reduced by:
a. F
b. T
c. T
d. T
26. Erythromycin stearate:
a. F
b. F: esters of erythromycin are formulated as enteric coated tablets.
c. T
d. F: inhibits protein synthesis by binding to 50S ribosomonal subunits of bacteria.
27. Gentamicin:
a. F
b. T
c. T
d. T
28. Metronidazole:
a. T
b. T
c. T
d. T
29. Bacteria develop resistance to an antimicrobial by:
a. F
b. T
c. T
d. T
30. Ampicillin:
a. T: resistant strains are emerging and ceftriaxone is now used for the treatment of acute infections instead.
b. F
c. T: can be given orally.
d. T