Pharmacology of the Cardiovascular and Central Nervous Systems

101.    The inappropriate statement(s) on dopamine are:

a.     it is a precursor for noradrenaline.

b.     it readily enters the blood-brain barrier.

c.     it is formed from L-dopa. 

d.     it is able to decrease the blood pressure by stimulating dopamine receptors.

102.    The pharmacological effects of codeine include:

a.     anti-tussive effect.

b.     anti-pyretic effect.

c.     analgesia.

d.     constipation.

103.    The following drugs are likely to cause physical dependence:

a.     diacetylmorphine.

b.     dextromethorphan.

c.     pethidine.

d.     naloxone.

104.   Phenothiazines:

a.      are extensively bound to plasma proteins.

b.      are well absorbed when taken orally.

c.      are mainly metabolized by oxidation and hydroxylation.

d.      their metabolites are excreted in the urine.

105.    Diazepam:

a.      is extensively bound to plasma proteins.

b.      is slowly absorbed with oral administration.

c.      is metabolized to desmethyl diazepam.

d.      has a half-life of 8h.

106.    Imipramine:

a.      is a tricyclic MAOI.

b.      causes excessive withdrawal effects.

c.      decreases effects of chlorpromazine by induction.

d.      can cause sedation.

107.    Chlorpromazine is used:

a.      to treat Huntington's disease.

b.      to treat acute and chronic syphilitic psychoses.

c.      to treat tardive dyskinesia.

d.      as an anti-emetic in chemotherapy. 

108.    Digoxin differs significantly from digitoxin in:

a.      therapeutic index.

b.      incidence of nausea and vomiting.

c.      extent of metabolism.

d.      usual route of administration.

109.    Pharmacodynamic actions of verapamil include:

a.      AV nodal conduction.

b.      positive inotropic effect on myocardium.

c.      depresses autorhythmicity of SA node.

d.      decrease tone of arterioles.

110.    Antimuscarinic effects may occur with the following drugs:

a.      hyoscine.

b.      promethazine.

c.      tricyclic antidepressants.

d.      chlorpromazine.

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