Pharmacology of the Cardiovascular and Central Nervous Systems

81.    Lithium carbonate:

a.     can be used in manic depression.

b.     is well absorbed orally.

c.     can cause muscle weakness and tremor. 

d.     can cause foetal abnormality.

82.    Imipramine:

a.     is demethylated to active metabolites.

b.     blocks the neuronal uptake of noradrenaline.

c.     can cause cardiac arrhythmias.

d.     raise the seizure threshold in epileptics.

83.    Adverse effects of phenothiazine derivatives are:

a.     tardive dyskinesia.

b.     muscle tremor.

c.     cholestatic jaundice.

d.     pigmentation of skin.

84.   Chlorpromazine produces the following:

a.      peripheral adrenergic receptor blocking action.

b.      a rise in body temperature.

c.      peripheral anti-muscarinic actions.

d.      depression of chemoreceptor trigger zone.

85.    Chlorpromazine:

a.      is excreted mainly unchanged.

b.      is eliminated rapidly from the body.

c.      accelerates its own metabolism by enzyme induction.

d.      has quinidine-like effects.

86.    Quidinine can increase digoxin toxicity by:

a.      displacement of digoxin from plasma protein binding sites.

b.      decreasing metabolic breakdown of digoxin.

c.      increasing bioavailability of digoxin.

d.      displacement of digoxin from tissue binding sites.

87.    Thiopentone is ultra-short-acting because it undergoes:

a.      significant first-pass effect.

b.      rapid dissociation into the brain.

c.      rapid re-distribution.

d.      rapid dissociation from plasma protein binding.

88.    Warfarin sodium:

a.      has a long onset of action.

b.      is active in vitro.

c.      is used to maintain anticoagulation

d.      metabolism is induced by carbamazepine.

89.    State true or false:

a.      Fentanyl is a more potent analgesic than morphine.

b.      Morphine produces physical dependence.

c.      Pethidine is the preferred over morphine in general anaesthesia.

d.      Indomethacin is used in the relief of postoperative pain.

90.    Action of diuretics:

a.      diuretics decrease potassium and increase digitalis toxicity.

b.      retention of lithium is increased by any diuretics that increase sodium excretion.

c.      is potentiated by NSAIDs.

d.      can produce glucose intolerance in diabetics.

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