Currently the methods of laser and non-laser (incoherent monochromic, narrow-band or broadband) light blood irradiation therapy - the methods of photohemotherapy - are widely applied in the treatment of different pathologies.

H. Kost et al. (1986) offered blood irradiation with incoherent narrow-band blue light for the treatment of patients with ischemic heart disease and hypertensive disease. The drop in low-density lipoproteins and cholesterol content of the blood serum was determined. Further studies proved the broad therapeutic activity of the blue light blood irradiation procedures.

In studies of medico-biological effects of extracorporeal blue light irradiation of blood V. I. Karandashov et al. (1996, 2000) detected dropping of viscosity of blood immediately after the reinfusion. The viscosity of the blood plasma also was reduced, but to less degree than viscosity of blood, and had correlation with concentration of blood proteins. All these have results in augmentation of flowability of blood and improvement of microcirculation.

The changes of viscosity of blood and hematocrit are determined by intravascular delution of extravascular fluid with lower concentration of high molecular weight proteins. After the completing the course of irradiation the viscosity of blood was always lower than it was before the treatment. The decrease of concentration of cholesterol, triglycerides, lipoproteins and glucose was also marked. Thus, the phototherapy by blue light did not damage the blood cells, but stipulated dropping of concentration of atherogenous lipids, glucose and bilirubin. The obtained alterations had tendency to increase and stabilization at carrying out of a course of phototherapy. At the same time studies showed that blue light does not affect the rheological properties of the blood in vitro.

The infusion of the blood irradiated with blue light had immunostimulative activity for patients with chronic asthmatic bronchitis. It was also shown that immediately after the infusion of irradiated blood all main parameters of respiratory function were improved, and the increasing of effect was detected during and after the course of treatment.

Blue light blood irradiation therapy presents very good results in the treatment of different pathologies. It looks like it combines the best properties of both UBI and LBI procedures. Probably in the near future the blue light blood irradiation therapy will be used much more actively, than today.