Drs. Prolla and Diehl's Case of the month ~ August 2006

Bilateral parotid nodules, 55-year old male, Warthin“s tumor (adenolymphoma)

Warthin“s tumor (adenolymphoma), 200x M-G-G staining, sheet of oncocytic cells, scattered lymphocytes

Warthin“s tumor (adenolymphoma), 500x M-G-G staining, sheet of oncocytic cells, detail view

Warthin“s tumor (adenolymphoma), 200x M-G-G staining, sheet of oncocytic cells, scattered lymphocytes, some background debris

Warthin“s tumor (adenolymphoma), 500x M-G-G staining, sheet of oncocytic cells, scattered lymphocytes, detail view

Warthin“s tumor (adenolymphoma), 500x M-G-G staining, sheet of oncocytic cells, scattered lymphocytes

Warthin“s tumor (adenolymphoma), 500x M-G-G staining, loose oncocytic cells or macrophages?

Warthin“s tumor (adenolymphoma), 200x M-G-G staining, agregate of lymphocytes

Warthin“s tumor (adenolymphoma), 500x M-G-G staining, detail view of agregate of lymphocytes

Warthin“s tumor (adenolymphoma), 100x H&E staining, oncocytic cell lining of spaces, lymphocytic stroma

Warthin“s tumor (adenolymphoma), 200x H&E staining, detail view of oncocytic cells and lymphocytes in the stroma


Cytologically, the Warthin tumor (adenolymphoma) has a double cell population: lymphocytes and oncocytic epithelial cells that line the cystic areas (sometimes with papillary projections). In the differential diagnosis one should consider the well-differentiated acinic cell carcinoma associated with lymphoid stroma .
All patients with this tumor survive, and the recurrence rate is about 5%. The Warthin tumor tends to be bilateral (10% of cases) and is usually found in the major glands, as seen in the present case.




Case August 2006 References List of cases Atlas
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