Ascites fluid: Mesothelial cell atypias


Drs. Prolla and Diehl's INTERESTING CASE OF THE MONTH May 2003 case C

500x M-G-G staining, loose mosaic of mesothelial cells

500x M-G-G staining, nuclear enlargement, some gaps between cells

500x M-G-G staining, windows and clasping between mesothelial cells

500x Pap staining, variability in cell morphology, anisonucleosis

500x Pap staining, peripheral vacuolization

500x Pap staining, mosaic pattern with gaps between the cells, in the inset one cell clasping another

In his excellent book Malignant Effusions. A multimodal Approach to Cytologic Diagnosis(Igaku-Shoin, Tokyo, 1996) - chapter 4 - Serosal reaction to Injury, p.26-51, Dr. Carlos W M Bedrossian discusses at length the great variability of mesothelial cells. This is important to know, to help to distinguish malignant mesothelial cells from their benign reactive or hyperplastic variants, or from metastatic adenocarcinoma cells. In this case we see several morphological characteristics of those benign changes: doublets, triplets, or mosaics with windows between the cells ( caused by microvilli), multinucleation, anisonucleosis, cytoplasm with sharp ecto-endoplasmic demarcation, clasp-like connections, etc.



Case A May 2003 Case B May 2003 References List of cases Atlas
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