Resume

Complete CV

Programs

Research Interests

Contact Information

MatTree

Name:                         Dr. Rishabh Bhandari
Date of Birth:             January, 5, 1979

Objective: To work on challenging interdisciplinary computational problems with an opportunity to prove and enhance my skill sets.

Educational and Work History

Manager (Medical Informatics)

Escorts Heart Institute and Research Centre, New Delhi, India

Nov-2005 to Present

[Business] Analyst (IT and Pharmaceutical Industry)

SmartAnalyst Inc, Gurgaon, NCR Delhi, India

Mar-2005 to Nov-2005

Placed in waiting list for doctoral admissions at the Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Consultant and Faculty (Bioinformatics and Computational Biology)

NIIT Ltd and IIT, Delhi

May-2004 to Present

Cleared National Eligibility Test for Junior Researcher Fellowship

Webmaster and Site Owner – http://www.mattree.org

Nov-2003 to Present

Was placed in the merit list for doctoral admissions at the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

Project Assistant (Bioinformatics Unit)

Institute of Genomics and Integrative Biology

May-2003 to Nov-2004

Cleared Graduate Aptitude Test in Engineering 95^th percentile

Post Graduate Diploma in Bioinformatics, Sep-2002 to Apr-2003

Institute of Genomics and Integrative Biology,

Council for Scientific and Industrial Research, New Delhi, India

Clinical Intern

University College of Medical Sciences

Apr-2001 to Apr-2002

MBBS (Medical Graduation), Aug-1996 to Mar-2001

University College of Medical Sciences,

University of Delhi, New Delhi, India

Admitted to BE Electrical Engineering (1996) - Delhi College of Engineering, New Delhi, India

High School, 04/1992-04/1996

Delhi Public School, R K Puram Branch,

New Delhi, India

Chief Skills

Full Breadth of Preclinical and Clinical Sciences as a part of Medical Education

Computational Molecular Biology as a part of education, research and teaching experience

Programming

Algorithms

Physical Sciences

Others

Standardised Tests Scores

Selected Projects

Schizophrenia In-Silico Drug Target Identification

Institute of Genomics and Integrative Biology (May-2003 to Nov-2004)

Objective: Identification of critical molecular mechanisms and elements responsible for causation of Schizophrenia.

Number of team members: 7 (Lead Scientist, Self, 3 More Doctors, 1 Doctoral Student, Project Head)

Designation: Chief Programmer and Medical Reviewer

Technologies/Skills: Psychiatry, Molecular Mechanisms and Pathology, Pharmacology, Molecular Biology, Project Design and Management, Database Design, User Interface Design, Visual Basic, NCBI online databases, HTML Parsing, Computational linguistics (Concept mining algorithms), Networks and graph theory

Achievements: Development of a generic tool which prioritises genes for experimental investigation based upon available molecular information and public literature (AIGene – 3700 lines). International presentation of literature review results at FAOBMB Congress, 2003

Status: Prototype ready, product being evaluated for further development, commercialization and patenting rights.

Computational Biochemical Pathway Dynamics

Institute of Genomics and Integrative Biology (May-2004 onwards)

Objective: Use and validation of numerical techniques to study biochemical pathway dynamics

Number of investigators: 2 (Self and a Doctoral Student)

Designation: Collaborator

Technologies/Skills: Biochemistry, Chemical Kinetics, MatLab (Differential Equation Solving, Symbolic Mathematics, Graphs and Visualization Techniques)

Achievements: 2 papers under review (A letter to editor reporting correction in a formula used for study of dynamics in a publication; and a full-length paper reviewing the various formulations in use for the study of (bio)-chemical concentration dynamics, their particular weakness in fine behaviour simulation and proposition of an alternative set of formulations which deal with the problem effectively)

Status: We have about 3 more full-length papers in partial completion.

Distance Matrix methods for Phylogenetic Analysis and Clustering

Personal Effort (December-2002 onwards)

Objective: Investigation of Phylogenies using distance matrix methods

Number of investigators: 1 (Self)

Designation: Individual investigator

Technologies/Skills: Molecular Sequence Alignment, Distance Calculation, Distance Matrix Algorithms for construction of trees, C++, CGI, HTML, Apache, PWS/IIS

Achievements: Discovery of an original algorithm for distance matrix clustering; a web server hosting three programs for mathematical manipulation of distance matrices (MatTree-The distance matrix program for generation of trees from distance matrices; TreeMat- Additively translates a tree back into a matrix; DiffMat- Compare different matrices and calculate measures of difference)

Status: Site accessible online via http://www.mattree.org. Work on comparison of trees in progress.

Particle Simulator

Personal Effort (March-1998 to July-2001)

Objective: Development of a program that simulates classical mechanics on a set of particles in a box

Number of developers: 1 (Self)

Designation: Individual

Technologies/Skills: Classical mechanics, statistical mechanics, 3D coordinate geometry, Vector Algebra, QuickBasic, Simulation techniques, Graphics programming, Projections and Cross Sections, Identification of temporal and spatial patterns, Cumulative measures, Random number generators

Achievements: Working prototype of Particle Simulator completed. (635 lines)

Status: Objective accomplished

Other significant activities and achievements

Peer Reviewed Publications and Presentations

“Novel disease candidate genes at schizophrenia and bipolar disorder linked chromosomal loci”

Sharma A, Bhandari R, Vidhani A, Chauhan C, Malhotra S, Jain S, Brahmachari SK

Presented - Satellite Meeting of 10th FAOBMB Congress (5th- 6th December, 2003)

“Involvement of GABA-A receptor chloride channel complex in isolation stress-induced free choice ethanol consumption in rats”

Mediratta PK, Mahajan P, Sharma KK, Bhandari R, Dubey SP

Published - Indian Journal of Experimental Biology 2003 Jan;41:47-52

“Modulation of development of tolerance to anticonvulsant effect of diazepam by flumazenil”

Tewary S, Mediratta PK, Mahajan P, Sharma KK, Bhandari R

Published - Indian Journal of Physiology and Pharmacology 2002 Oct;46(4):507-10

Additional Training

1 month full-time training in Clinical Neuroelectrophysiology including EEG, Nerve Conduction Tests, BAER, Auditory and Visual Evoked Potentials and Cognitive Evoked Potentials

Non-academic Activities and Achievements

Tabla and Pakhawaj (Beat instruments) - Was part of school and college choirs.

Stage acting - Directed and acted in 2 plays at UCMS, acted in one skit at IGIB

Debating and quizzing secretary - UCMS

Hostel mess secretary - UCMS