Hi, My name is Daniel Leclerc

(Montreal Children's Hospital� Research Institute)

My interests� are:

Molecular Biology,� Genetics

My current position is:

Research Associate,
Department of Medical Genetics,
(Dr Rima Rozen Laboratory)
Montreal Children's Hospital

Address:

McGill University- Montreal Children's Hospital,
Research Institute (Place Toulon),
Daniel Leclerc,
Research Associate,
(Dr Rima Rozen Laboratory)
Medical Genetics - Room 242,
4060 Ste-Catherine West,
� Montreal, Qc
CANADA
H3Z 2Z3

Email address: [email protected]

Phone: 514-412-4400 ext. 23281

FAX: 514-412-4331

I am performing research in Molecular Biology and Human Genetics
at the Montreal� Children's Hospital� (McGill University).
Projects are related to vitamin B12 and folate metabolism.

In past years, I focused on:

Methylcobalamin deficiency
and
cblG disease

See (general reference):
Leclerc, D., Campeau, E., Goyette, P., Adjalla, C.E., Christensen, B., Ross, M., Eydoux, P., Rosenblatt, D.S., Rozen, R. and Gravel, R.A. (1996)
Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.
Hum. Molec. Genet., 5, 1867-1874.
(PDF file)

I have been also very interested by:

cblE disease
and
Methionine synthase reductase deficiency

See (general reference):
����� Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H.H.Q., Rommens, J.M., Scherer, S.W., Rosenblatt, D.S. and Gravel, R.A. (1998)
Cloning and mapping of a cDNA for methionine synthase reductase
a flavoprotein defective in patients with homocystinuria.
��� Proc. Natl. Acad. Sci. U.S.A., 95, 3059-3064.
(PDF file)

������� Gene structure of MTRR gene is now well determined
����
See :
Leclerc, D., Odievre, M.-H., Wu, Q., Wilson, A., Huizenga, J.J., Rozen, R., Scherer, S.W. and Gravel, R.A. (1999)
Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene.
����� Gene 240, 75-8
(PDF file)

Several of the mutations in MTRR gene (mutations causing cblE disease) are documented in:�

Wilson, A., Leclerc, D., Rosenblatt, D.S. and Gravel, R.A. (1999)
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
� Human Molecular Genetics 8, 2009-2016.
�� A PDF file is available.���

Send email to:
[email protected]