Morinda Citrofolia (noni) y  Graviola (guanabana) !!!

Data-Medicos 
Dermagic/Express No. 4-(116) 
05 Octubre 2.002 / 05 October 2.002 

EDITORIAL ESPANOL 
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La morinda Citrofolia (noni) Hierba oriunda de Hawai, y la Graviola (Guanabana),  un arbol frutal que crece en las areas tropicales de Norte y Sur America hasta el Amazonas, representan 2 grandes alternativas terapeuticas contra el cancer, vale la pena intentarlo antes que entregarnos a la muerte. 

Lean estas interesantes referencias que espero ayuden a todos quienes estan luchando contra esa plaga llamada cancer y que la Ciencia hoy dia muy probablemente se niega a darnos la medicina tradicional curativa que ya existe en los arsenales terapeuticos de los grandes gobiernos Ellos no quieren ayudarnos, porque no les interesa ??? entonces luchemos con lo que tenemos a nuestro alcance !!!

En las referencias los hechos !!!

Dr. Jose Lapenta R.

ENGLISH EDITORIAL 
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The morinda Citrofolia (noni) Grass from Hawai, and the Graviola (Guanabana), fruit-bearing tree that grows in the tropical areas in South and North America including the Amazon, they represent 2 big therapeutic alternatives against the cancer, it is worthwhile to attempt it before to surrender to the death. 

Read these interesting references that I wait they help all who are fighting against that plague called "cancer" and that the Science nowadays very probably refuses to give us the healing traditional medicine that already exists in the therapeutic arsenals of the big governments. Don't they want to help us, because it doesn't interest them??? then we do fight with what we have within our reach !!!!

In the references, the facts !!!

Dr. Jose Lapenta R.

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1.) MORINDA CITROFOLIA - NONI
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Source:www.timewealth.com             The Noni

In 1990, Mr. Herbert Moniz, a licensed massage therapist on the island of Maui, in Hawaii, invented a method of processing the Noni fruit into powder and putting it into capsules, thus eliminating its pungent odor and taste, making for easy consumption.



Mr. Moniz, who recently was granted U.S. Patent No. 5,288,491 for his powdered Noni as a pharmaceutical product, processes and distributes his Noni capsules under the brand name "Maui Noni" by Herb's Herbs. This is his story...I am Herbert Moniz, a licensed Massage Therapist, President and sole Owner of Herb's Herbs, Inc. I was the first to transform the Noni Fruit into powder form and put it into capsules. People constantly ask me: "How did you get involved with the Noni and what inspired you to put it into powder form?" It's been uphill all the way, and was made especially difficult by the County, State and Federal authorities to accomplish this dehydration process - but the Inspiration is one that carried me through with a firm commitment to make Noni into a form that everyone could benefit from.

Well, in the year of 1985, my wife Lona had breast Cancer. She went through the whole nine yards of chemotherapy and radiation. Several months went by, and one day my wife's cousin said to her, "why don't you take Noni for prevention of further cancer, and also to build your body up again". Come to think of it, she had forgotten all about taking Noni, it had completely slipped her mind. Her Tutu Wahine (Grandmother in Hawaiian) had always told them as children: "Noni is medicine, so treat this Tree and 'every part' of it with great respect". But her Tutu Wahine had never told her what they used it for.

So Lona's cousin brought her Noni and she ate the fresh pulp, keeping it in the refrigerator. One day I saw this 'thing' in the refrigerator and said to myself "Oh! Tonight I'm going to eat some poi (kalo/taro pounded into a traditional Hawaiian food) for dinner". Well, much to my surprise when I opened the bag - I was amazed as to how she could take this foul smelling, awful tasting pulp. She replied, "If you're sick enough you'll take it, if it will do you good" and she took 2 tablespoons of it every morning.

That along with God's Blessing gives me my wife today and she thanked the Lord for this precious fruit, because her cancer never came back. He put this fruit on earth for one reason, to help people to help themselves. God's gift to mankind is Noni. Man's gift to God is Love, Faith, and most of all, Thanks.

So, then I started taking it. But I couldn't eat it. Then one day while I was working on a patient doing my massage therapy, all I could see in my mind and think of was capsules. I was saying to myself, "Why am I thinking of capsules?" All of a sudden it came to me, "I can put this Noni into capsules!" And thousands of people all over the world can get it, to help them for whatever their needs might be. So I tried dehydration, but the process did not come out right. I had all kinds of problems with the temperatures.... it would burn, or it would not dry. (I've been working on Noni for years.)

But I did not give up. One night while I was asleep, about 1:00 - 1:30 a.m. it came to me in a dream: figures and numbers. I immediately got up and wrote it down on paper, and ever since then, till this day, it has never failed. Thank God! I thank Him everyday, for this Gift he gave me - for it truly is a gift from Him. It was in his plans. God could have taken my wife Lona, but he saved her with Noni and picked one to perfect the Noni to distribute the Noni fruit in powder form, in capsules, for the world.

I am the first person to change this fruit into powder form, and make it available in capsules. There is a reason for all of this. God is telling people, this is your last chance, and there will be a long time after the Noni, to find another replacement to fight bacteria. Noni purifies and oxygenates the blood.

I perfected the Noni, and I've sold it all over the world. I've sent it to Japan, Germany, England, and most of the United States. Then in February 1992 the state of Hawaii FDA stopped me from selling Noni. They said I was making claims -- medical claims that is -- but I wasn't. I had health claims by people who had used the Noni, they would call me to say that the Noni had really helped them for whatever their problems were.

Anyway - I stopped selling it. For the next three years I didn't give up. I sent it away to be analyzed at different labs, I worked back and forth with the State of Hawaii FDA until I had it passed as G.R.A.S. (Generally Recognized As Safe). It took a long time for it to be approved by them. It also cost me a lot of money. But it paid off, for now I know that I have the best product anyone can wish for.

We pick Noni only along the coastal areas and lava flow areas as we found that it has more potency than inland Noni. The lava is very high in vitamins and minerals, and the salt water from the ocean makes it the best Noni available.

All I can say is, try it and see what Maui Noni can do for you! Love & Aloha,
Herbert Moniz

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2.) The Noni Plant, A Hawaiian Gift of Healing
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Source:www.timewealth.com

The distant ancestors of today's Polynesians are believed to have migrated to Hawaii from Southeast Asia. Several centuries before the time of Christ these sturdy and brave people set out upon great sea voyages in humble canoes arriving in the area of central Polynesia around the time of Christ, or approximately about 100 AD. Over the next several centuries the distinctive Polynesian culture emerged and was dispersed to all the islands now considered to constitute Polynesia, which extends in an arc from New Zealand in the southwest to Hawaii in the northeast. 

When these first settlers began their journey into the unknown they took with them the plants and animals they considered to be essential for their survival in the new lands they sailed toward. 

Of the plants these settlers brought with them many had applications for clothing, building supplies, containers, dyes, etc., but most were primarily food and medicinal plants. Taro, yam, breadfruit, bananas and sugar cane are five of the Polynesian food plants that have origins in Southeast Asia. Of the twelve common Polynesian medicinal plants used by the Hawaiians, eight of the most popular plants are believed to have been brought to Hawaii from south and central Polynesia in canoe voyages about 1,500 years ago. Although about 317 species of plants were believed to be employed by 19th century Hawaiians for herbal medicinal purposes, only a very small number were commonly used for the most frequent health complaints.

According to Dr. Isabella Abbott, of the University of Hawaii, Hawaiians that relied on herbal cures suffered from the same ailments that we, today, consider to be a part of modern every day life (with the notable exception of "headaches"). Before contact with the West (Captain Cook arrived in 1778) the isolated Hawaiians were relatively disease free. Their medical conditions addressed by herbal cures fell in the range of malignancies or tumors, purges or consumption, skin afflictions, respiratory affections (including asthma), indigestion, conditions associated with pregnancy, childbirth and old age, fever and bruises, broken bones, sprains and cuts.

Contact with Captain Cook's crews introduced gonorrhea, syphilis and tuberculosis, and continued contact in the 1800's decimated the Hawaiian population with measles, small pox, cholera, mumps, influenza, pneumonia, leprosy and other diseases. The Hawaiian pharmacopoeia could not deal with these diseases, but the Western medicine had no cures for them either at that time.

One of the great tragedies of this devastation of the Hawaiian population was the loss of information in many areas of Hawaiian culture, including the area of herbal medicinal knowledge. The Hawaiian tradition required their men and women who held knowledge in all areas of Hawaiian society to chose an apprentice to pass that knowledge on to before they died. This was essential as most of their teachings and traditions were taught verbally. The epidemics brought by contact with the Western world swept through the Hawaiian peoples in a swift and deadly manner that allowed no time for the ancient knowledge of several thousands of years of civilization to be passed on. What little knowledge we have left to us today has come from the efforts of early historians who tried to capture in writing the details of practice and belief of the Hawaiians before the 1820's, and the efforts of modern researchers to record the common knowledge of the older Hawaiians.

Today, ancient Hawaiian medical knowledge is coming under the scrutiny of renewed interest spurred on by researchers in the fields of ethnobotany and ethnopharmacology. The call has gone out for systematic studies to determine pharmacologically active compounds among the Hawaiian medicinal plants. The need for these studies is underscored by the fact that today, in Western medicine, 60 per cent of written prescriptions are for substances that are naturally occurring in nature. The paucity of studies to date on Hawaiian medicinal herbs means that the "knowledge of the pharmacological properties of the majority of Hawaiian herbs is still incomplete" says Dr. Isabella Abbott of the University of Hawaii.

Dr. F.L. Tabrah and Dr. B.M. Eveleth, in a report to the Hawaii Medical Journal, entitled Evaluation of the Effectiveness of Ancient Hawaiian Medicine, stated that the "Hawaiian Kahunas were highly specialized experts with considerable skill in physical diagnosis and pharmacology". A "Kahuna" was a learned teacher of an ancient body of spiritual, medical and philosophical knowledge called the Huna. Huna translates as "That Which is Hidden" and a Kahuna was simply a teacher of the Huna. The Hawaiians readily accepted the Christian teachings of the missionaries because the Huna also stated that there was one God and they considered Jesus to have been a great and powerful Kahuna. The Kahunas of ancient Hawaii, before their own cultural corruption by greedy and bloodthirsty rulers and the subsequent loss of knowledge caused by the arrival of the white man were reputed to be able to perform the self-same miracles attributed to Jesus, including instantaneous healing and revival of the dead. When the people realize that the missionary priests were not able to duplicate the miracles of Jesus, their Kahunas rebelled and went back to the old practices. The missionaries, to protect their efforts at converting the Hawaiians to their Christian beliefs, had laws passed to declare the practice of the Huna illegal and punishable by fines and imprisonment. It was not until the 1960's that these laws were repealed. In this manner a large body of knowledge was lost, perhaps forever.

The ancient Hawaiian knowledge of medicine was practiced by several different and distinct classes of Kahunas. The Hawaiians recognized two categories of disease. Those caused by forces from without the body, and those caused from forces within. The illnesses from within were treated by the kahuna haha (medical diagnostician), kahuna lapa`au (medical doctor) or the kahuna la`au lapa`au (herbalist).

The Kahuna la`au lapa`au began training at the age of five in the home of his or her mentor. Over a period of approximately 20 years they learned about the medicinal plants, their effect on the body, where they grew and how to prepare and administer them. There are a few Kahuna la`au lapa`aus whom practice today, and their array of medicinal plants still include those plants used by the ancient Hawaiians, with the addition of some modern plants such as Aloe Vera and comfrey.

Noni, whose scientific name is Morinda citrifolia, also called Indian Mulberry, was one of the important plants that were brought to Hawaii by the first Polynesians. Although, as mentioned before, there are 317 species of plants that were documented by Kaaiakamanu and Akina in 1922 to have been used by pre-20th century Hawaiian herbalists, only a very small number were commonly used for known physical conditions of illnesses. Of the 12 most commonly mentioned plants (8 of which were brought from Southeast Asia) Noni was the second most popular plant mentioned for use in herbal remedies. Ethnobotanical studies from Indonesia verify many of the same uses for Noni as those reported by the Hawaiians.

The Hawaiians utilized the whole Noni plant. The roots, stems, bark, leaves, flowers and fruit are all mentioned in various combinations in the almost 40 known and recorded herbal remedies involving Noni. In addition, the roots were used to produce a yellow or red dye for the tapa cloths, and the fruit was eaten during times of famine. There are numerous Polynesian stories of heroes and heroines that survived famine by eating the Noni. There is one tale of Kamapua`a, the pig god who loved Pele the volcano goddess, taunting Pele with the chant, "I have seen the woman gathering Noni / Scratching Noni / Pounding Noni". Supposedly, the chant referred to Pele's eyes which were red, and she became so angry she plunged into battle with him. A Tongan myth tells of the god Maui being restored to life by having the leaves of the Noni placed on his body. 

The Noni plant is a small evergreen tree found growing in open coastal regions at sea level and in forest areas up to about 1,300 feet above sea level. The plant is often found growing along lava flows. 

It's identifiable by its straight trunk, large, bright green and elliptical leaves, white tubular flowers and its distinctive, ovoid, "grenade-like" yellow fruit. The fruit can grow to 12 cm or more and has a lumpy surface covered by polygonal-shaped sections. The seeds, which are triangular shaped and reddish brown, have an air-sac attached at one end which makes the seeds buoyant, (this could explain, in part, the wide distribution of the plant throughout the Hawaiian Islands). The Noni fruit, when mature, has a foul taste and odor. The smell and taste of the fruit pulp is so foul that one researcher pronounced it akin to 'vomitus'! Although well known and popular in the islands, (the University of Hawaii's Botany department receives about 10 calls a week from people trying to locate a source of Noni) this characteristic, until now, has been a definite barrier to its widespread use on the mainland.

In 1992, Mr. Herbert Moniz, a licensed massage therapist and lifetime resident of Maui, developed a process to dehydrate the Noni fruit into a powder that is smell-less and tasteless when placed in capsules. Mr. Moniz learned about the Noni fruit and its believed medicinal value when a family friend recommended it to his wife, Lona, who was undergoing treatment for breast cancer. When Mrs. Moniz's cancer did not recur, Mr. Moniz developed the process by which the Noni fruit is pulped, the seed removed and saved for propagation of new plants, and the pulp then dried into powder form.

The medical knowledge and pharmacopoeia of the ancient Hawaiians is now believed to have been fairly complex and specific, and the modern day scientific and medical communities are beginning to study the plants that were used by the Hawaiian Kahunas. The importance of these studies is underscored in a quote from a 1987 report in the Journal of Ethnopharmacology: "In the past, the pharmaceutical industry has often relied on tropical plants as sources of new drugs (e.g. quinine, vincristine, tubocurine, reserpine, cocaine and many others). If the industry is to continue to use plants to develop new products, there is an urgent need for the collection of basic ethnobotanical data..."

In a report to the 83rd Annual meeting of the American Association for Cancer Research in May of 1992 (Hirazumi, A., Furusawa, E., Chou, S.C., Okano, C. and Ching, C., University of Hawaii, Dept. of Pharmacology and Dept. of Medicine) the juice of the fruit of the Noni plant was shown to significantly prolong the life of mice with implanted Lewis lung carcinoma. Their conclusion was that it seemed to suppress tumor growth indirectly by stimulating the immune system. The mechanism of stimulation is still unknown and is under further study.

In a paper published in 1949 in the Pacific Science, a quarterly devoted to the biological and physical sciences of the Pacific Region, the fruit of the Noni exhibited moderate antibacterial properties against the bacteria M. pyrogenes, E. coli and Ps. aeruginosa.

Most recently, in an article published in the Honolulu Star Bulletin on 9 February, 1992, Professor of Botany at the University of Hawaii, Isabella Abbott, was quoted as saying "People are crazy about this plant. They use it for diabetes, high blood pressure, cancer and many other illnesses." Also, former U of H researcher, Dr. Ralph M. Heinicke, states that the fruit of Noni contains a natural alkaloid xeronine, as well as a chemical that is converted to xeronine in the digestive tract. The ailments he believes may possibly be helped by Noni are: high blood pressure, menstrual cramps, arthritis, gastric ulcers, sprains, injuries, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, drug addiction and pain. In addition, locally, people have reported success by using Noni to treat breast cancer, and eye problems. Dr. Joseph Betz, a research chemist with the FDA's Division of Natural Products Center for Food Safety and Applied Nutrition states, "Morinda citrifolia has been tested for a number of biological activities in animal and anti-microbial studies." He reports that the dried fruit has a smooth muscle stimulatory activity and a histaminergic effect. The root was also reported as possessing analgesic and tranquilizing activity. In the September 30, 1993 issue of Cancer Letters a report out of Keio University and The Institute of Biomedical Sciences in Japan claimed isolation of a new anthraquinone compound from the Noni root called damnacanthal which induced normal morphology and cytoskeletal structure in K-ras-NRK cancer cells.

Today's researchers in the emerging fields of ethnobotany and ethnopharmacology are reaching back through time to discover again what the ancient Polynesians knew as they carefully, lovingly placed the young shoots of the valuable Noni plant into their canoes, among the bananas, taro and yams, and set out for horizons unknown. Almost nothing is known now about these early Hawaiians, how they worshipped and what they would talk about amongst themselves as they watched the brilliant tropical sun set, once again, into the vast and lonely ocean that kept them isolated from the rest of the world for almost 2,000 years. They've disappeared, the veil of time leaving us only hints of their lives, and the evergreen gift of the Noni.
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3.) Cancer preventive effect of Morinda citrifolia (Noni).
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Ann N Y Acad Sci 2001 Dec;952:161-8 

Wang MY, Su C.

Department of Pathology, UIC College of Medicine, Rockford, Illinois 61107, USA. [email protected]

Morinda citrifolia (Noni) has been extensively used in folk medicine by Polynesians for over 2,000 years. It has been reported to have broad therapeutic effects, including anticancer activity, in both clinical practice and laboratory animal models. The mechanism for these effects remains unknown. The hypothesis that Morinda citrifolia possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied. Our preliminary data indicated that 10% Tahitian Noni Liquid Dietary Supplement or Tahitian Noni Juice (TNJ), made from Morinda citrifolia fruit by Morinda Inc, in drinking water for one week was able to prevent DMBA-DNA adduct formation. The levels of DMBA-DNA adducts were reduced by 30% in the heart, 41% in the lung, 42% in the liver, and 80% in the kidney of female SD rats. Even more dramatic results were obtained in male C57 BL-6 mice: 10% TNJ was able to reduce DMBA-DNA adduct formation by 60% in the heart, 50% in the lung, 70% in the liver, and 90% in the kidney. In order to explore the mechanism of this preventive effect, the antioxidant activity of TNJ was examined in vitro by lipid hydroperoxide (LPO) and tetrazolium nitroblue (TNB) assays. In the LPO assay, LPO oxidizes leucomethylene blue to methylene blue in the presence of hemoglobin. The resultant blue color was quantified at 660 nm spectrophotometrically. In the TNB assay, superoxide anion radicals (SAR) reduce TNB into formazan blue that was also measured by absorption at 602 nm. TNJ showed a dose-dependent inhibition of both LPO and SAR in our system. The antioxidant activity of TNJ was compared to the effects of vitamin C, grape seed powder (GSP), and pycnogenol (PYC) at the daily dose per serving level recommended by U.S.RDAs or manufacturers. The results suggest that prevention of carcinogen-DNA adduct formation and the antioxidant activity of TNJ may contribute to the cancer preventive effect of Morinda citrifolia.


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4.) Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
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Cancer Res 2001 Aug 1;61(15):5749-56 

Liu G, Bode A, Ma WY, Sang S, Ho CT, Dong Z.

The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

The fruit juice of Morinda citrifolia (noni), a plant originally grown in the Hawaiian and Tahitian islands, has long been used by islanders to treat diseases, including cancer. Two novel glycosides, 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose and asperulosidic acid, extracted from the juice of noni fruits, were used to examine their effects on 12-O-tedtradecanoylphorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced AP-1 transactivation and cell transformation in mouse epidermal JB6 cells. The results indicated that both compounds were effective in suppressing TPA- or EGF-induced cell transformation and associated AP-1 activity. TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.


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5.) A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L.
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Org Lett 2001 May 3;3(9):1307-9 

Sang S, He K, Liu G, Zhu N, Cheng X, Wang M, Zheng Q, Dong Z, Ghai G, Rosen RT, Ho CT.

Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, USA. [email protected]

[structure in text] From the leaves of Morinda citrifolia, a new unusual iridoid, named citrifolinoside (1), showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, has been isolated. Its structure was elucidated on the basis of detailed high-field 1D and 2D spectral analysis.

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6.) An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity.
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Phytother Res 1999 Aug;13(5):380-7 

Hirazumi A, Furusawa E.

Department of Pharmacology, John A., Burns School of Medicine, 1960 East West Road, University of Hawaii, Honolulu, HI 96822, USA.

The fruit juice of Morinda citrifolia (noni) contains a polysaccharide-rich substance (noni-ppt) with antitumour activity in the Lewis lung (LLC) peritoneal carcinomatosis model. Therapeutic administration of noni-ppt significantly enhanced the duration of survival of inbred syngeneic LLC tumour bearing mice. It did not exert significant cytotoxic effects in an adapted culture of LLC cells, LLC1, but could activate peritoneal exudate cells (PEC) to impart profound toxicity when co-cultured with the tumour cells. This suggested the possibility that noni-ppt may suppress tumour growth through activation of the host immune system. Concomitant treatment with the immunosuppressive agent, 2-chloroadenosine (C1-Ade) or cyclosporin (cys-A) diminished its activity, thereby substantiating an immunomodulatory mechanism. Noni-ppt was also capable of stimulating the release of several mediators from murine effector cells, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-10, IL-12 p70, interferon-gamma (IFN-gamma) and nitric oxide (NO), but had no effect on IL-2 and suppressed IL-4 release. Improved survival time and curative effects occurred when noni-ppt was combined with sub-optimal doses of the standard chemotherapeutic agents, adriamycin (Adria), cisplatin (CDDP), 5-fluorouracil (5-FU), and vincristine (VCR), suggesting important clinical applications of noni-ppt as a supplemental agent in cancer treatment. Copyright 1999 John Wiley & Sons, Ltd.


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7.) Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice.
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Proc West Pharmacol Soc 1996;39:7-9 

Hirazumi A, Furusawa E, Chou SC, Hokama Y.

Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822, USA.

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8.) Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice.
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Proc West Pharmacol Soc 1994;37:145-6 

Hirazumi A, Furusawa E, Chou SC, Hokama Y.

Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu.

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9.) Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.
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Cancer Lett 1993 Sep 30;73(2-3):161-6 

Hiramatsu T, Imoto M, Koyano T, Umezawa K.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.

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10.) Antitumor agents 50. 1 Morindaparvin-A, a new antileukemic anthraquinone, and alizarin-1-methyl ether from Morinda parvifolia, and the antileukemic activity of the related derivatives.
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J Nat Prod 1982 Mar-Apr;45(2):206-10 

Chang P, Lee KH, Shingu T, Hirayama T, Hall IH, Huang HC.

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11.) Anti-neoplastic property of a crystalline compound extracted from Morinda lucida.
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Planta Med 1974 Nov;26(3):208-11 

Durodola JI.

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12.) The Pharmacologically Active Ingredient of NONI.
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Source:www.timewealth.com

R.M. Heinicke, university of Hawaii.
In "The Bulletin ", in April 1972, Maria Stewart described how the Hawaiians solved many of their medical problems by drinking infusions of the fruit of the noni tree (Morinda citrifolia , Rubiaceae). The missionaries, who frequently had to minister to the body as well as the soul, were impressed with the efficacy of these options. Yet identifying the pharmacologically active ingredient of noni has been difficult - for an understandably good reason. The active ingredient is not present in the plant or fruit! Only after the potion has been drunk does the active ingredient form. Sometimes! 
My search for the ingredient which is active in noni began with a series of studies on the pineapple plant. Since about 1972 I had been attempting to identify the unknown ingredient in "bromelain" which gives crude preparations of this enzyme their potent pharmacological properties. (Sometimes!) After many discouraging years of research I eventually identified this ingredient as a new alkaloid to which I gave the name "xeronine." Noticing that the clinical claims of efficacy for bromelain and noni were practically identical, I tried the same techniques on noni fruit which I had developed for isolating xeronine from the pineapple plant. The technique worked! Not only was I able to isolate the same compound from noni fruit, but he yields were excellent. Today noni is one of the best raw materials to use for the isolation of xeronine. 
Xeronine is a relatively small alkaloid which is physiologically active in the picogram range. (Ed. note: a picogram is one trillionth of a gram) It occurs in practically all healthy cells of plants, animals and microorganisms. However, the amount of free alkaloid is minute and is well below the limits of normal chemical analytical techniques. 
Even though noni fruits have a negligible amount of free xeronine, they contain appreciable amounts of the precursor of xeronine. This precursor, which I have named "proxeronine", is a strange molecule. The molecular weight is relatively large, namely about 16,000. In contrast to most plant colloids, this colloid contains neither sugars, amino acids nor nucleic acids. Thus most biochemists have overlooked this relatively abundant molecule which occurs in most tissues. 
Noni fruits also contain the inactive form of the enzyme which releases xeronine from proxeronine. Unless this proenzyme becomes properly activated, however, noni juice will cause few pharmacological reactions. Fortunately if noni juice is taken on an empty stomach, the critical proenzyme escapes digestion in the stomach and enters the intestines. Here, the chances are high that it may become activated.
Many years of research are still required to demonstrate convincingly how xeronine functions at the molecular level in a cell. In the meantime I can suggest certain hypotheses which can act as a guide in planning experiments. I am basing these hypotheses both on clinical results with bromelain pills as well as on a limited number of laboratory and animal experiments carried out with pure xeronine.
I am proposing that the primary function of xeronine is to regulate the rigidity and shape of specific proteins. Since these proteins have different functions, we have the usual clinical situation where administering one simple drug causes an unbelievably wide range of physiological responses. 
The action which xeronine has on a person depends upon which of his tissues has a suboptimal level of xeronine. Thus xeronine can alleviate certain subsets of almost any known disease. For no disease, however, will xeronine be a panacea. A physiological disease, for example senility, may be caused by a deficiency or imbalance of a number of different biochemicals as well as by malfunctioning blood vessels, hormone systems or immune bodies. Only if the disease is specifically caused by a lack of xeronine will xeronine alleviate the symptoms of the problem.
I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert forms of enzymes which require absorbed xeronine to become active. Thus xeronine, by converting the body's procollagenase system into a specific protease, quickly and safely removes the dead tissue from burns. It is for this reason that aloes, bromelain and noni are such effective treatments for burns. Other proteins become potential receptor sites for hormones after they react with xeronine. Thus the action of ginseng, bromelain and noni in making a person feel well is probably caused by xeronine converting certain brain receptor proteins into active sites for the absorption of the endorphins, the well being hormones. Other proteins form pores through membranes in the intestines, the blood vessels and other body organs. Absorbing xeronine on these proteins changes the shape of the pores and thus affects the passage of molecules through the membranes. Thus the action of bromelain, noni and ginseng in improving digestion may be ascribable to this action. These are just a few of the many exciting actions of this newly discovered alkaloid. Since noni is a potential source of this alkaloid, noni juice can be a valuable herbal remedy. 
There are some practical problems, however, in using noni juice as a medicine or tonic. If one is dying and all other remedies have failed, then and only then will the average person drink noni juice. The flavor of juice made from ripe Hawaiian noni is terrible. None of my colleagues would touch the untreated juice. Even after I had removed most of the disagreeable flavor (several organic acids) from the juice, my colleagues still found it unfit to drink. For a price the odoriferous chemicals can be removed from the Hawaiian variety. However, other varieties grown in other Pacific Islands are milder in flavor.
Another critical problem in using noni juice as a medicine or health tonic is timing. If the juice is drunk on a full stomach, it will have very little beneficial action. The pepsin and acid in the stomach will destroy the enzyme which liberates xeronine. For a seriously sick person taking the juice on an empty stomach rarely poses a problem; the patient is too sick to want to eat anything. However, for the average person who wants to drink noni juice as a health tonic, timing is critical. I would recommend taking 100 ml of noni juice a half hour before breakfast. At this time the juice will pass rapidly through the stomach and into the intestines, where it may be converted into the active enzyme. At any other time of the day, especially at meal times, the primary effects of drinking noni juice will be psychological and caloric. Because of the strong flavor the psychological effect might not necessarily be positive. To obtain the maximum effect of the active ingredient in noni, I would recommend also that noni juice not be taken with coffee, tobacco or alcohol. At times the combination of these materials and noni can give some unexpected side effects. At other times the combination merely lowers the potentially beneficial effect of xeronine. 
Although the Hawaiian recommended both green fruit and ripe fruit for treating various ailments, my personal recommendation would be to use only the green fruit. The green fruit has more of the potentially valuable components and less of the undesirable flavor. In light of the new information on the action of xeronine what are some of the possible applications of noni juice?
First I should make the caveat that for all of the possible applications which I am listing, one must always add the phrase "some types but not other types." Some of the problems which drinking noni juice might favorable affect are: high blood pressure, menstrual cramps, arthritis, gastric ulcers, sprains, injuries, mental depression, senility, poor digestion, atherosclerosis, blood vessel problems, addiction, relief for pain and many others. Although this list looks like a page torn out of traveling medicine man's manual, it is probably conservative. 
The old Hawaiian people were truly fortunate to have herbal medical doctors who recognized a valuable natural product and who knew how to administer this medicine with the proper psychological persuasion.

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13.) La Farmacia natural de la Polinesia
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Source:www.freeyellow.com

El Noni (Morinda Citrofolia ) se ha venido usando por las sanadores polinesios para tratar fiebres de niños o siendo colocada en una diapositiva para su examen más cercano en el laboratorio de un bioquímico, el fruto del noni tiene una historia más intrigante y un futuro más emocionante que cualquier medicamento natural disponible en el mundo. Noni es el nombre hawaiano común de la Morinda citrifolia. La planta originaria de la Polinesia, Malasia, Australia, India y el Sureste de Asia, es un tipo de planta de hojas perenne cuyo tamaño varía desde un pequeño arbusto hasta un árbol de 6 a 10 metros de altura. Debido a su valor medicinal y nutritivo, la M. Citrifolia se considera la reina de las otras 80 especies que pertenecen a la antigua familia mundial de las rubiáceas.

Aproximadamente del tamaño de una papa el fruto de NONI tiene una apariencia grumosa con una cáscara cerosa y traslúcida cuyo color puede variar desde verde hasta casi negro. Los aborígenes de Polinesia lo reconocen sin necesidad de verlo debido a rancio olor y sabor de su fruto cuando está completamente maduro. Este fruto de forma poligonal tiene numerosos huesos que contiene varias semillas. Se le llama planta errante porque adjunta a cada semilla hay una bolsa de aire que le permite viajar sobre el agua por meses, de una isla a otra.

Más rara que la apariencia y el olor del Noni es su larga historia de usos medicinales eficaces por los aborígenes. Los sanadores tradicionales polinesios empleaban todas las partes de la planta del Noni, flores, corteza, raíces y especialmente, el fruto para tratar problemas de salud que iban desde las aftas hasta el reumatismo. Las lombrices intestinales, fiebres y las infecciones de la piel eran algunas de las enfermedades más comunes tratadas con esta panacea polinesia.

El Noni está recibiendo más atención de los herbólogos, médicos y bioquímicos de alta tecnología de la actualidad. Estudios científicos realizados en los últimos años apoyan las afirmaciones de los polinesios con respecto a su raro poder curativo. Estos estudios han demostrado que el jugo del fruto contiene atributos curativos incluso, pero sin limitarse a compuestos antibacterinos, antiinflamatorios, analgésicos, hipotensivos e inhibidores del cancer. Estos estudios implican al noni como un medicamento natural que reduce la presión sanguínea y la inflamación de las articulaciones, detiene las infecciones internas y externas, despeja las congestiones y hasta evita el crecimiento de células precancerosas.

Además, un investigador, el Dr. Ralph Heiniche, quien anteriormente trabajo en la Universidad de Hawai, ha identificado que el fruto de noni contiene una proenzima que estimula al cuerpo humano para producir xeronina, un elemento vital para las moléculas proteínicas del cuerpo. 

Debido a sus propiedades fortalecedoras de las proteínas, la xeronina alcalóidea afecta potencialmente el cuerpo humano en una multitud de maneras que van desde el aumento de la vitalidad de una persona hasta la reducción de la dependencia de las drogas. Las proteínas son los catalizadores más importantes del cuerpo humano y afectan casi todos los aspectos de la salud de las personas. La aplicación de la Xeronina del Noni a quemaduras extrernas y tejidos infestados ha acelerado considerablemente el tiempo necesario para que los tejidos se reparen solos. Otros trastornos internos y neurogénicos también pueden reaccionar positivamente a la xeronina debido a la habilidad de dicho compuesto para normalizar las proteínas encontradas en todos los tejidos vivientes esenciales, aún los del cerebro.

Source: www.rain-tree.com  

GRAVIOLA

 

DESCRIPTION
Properties/Actions:	Antibacterial, Anticancerous, Antiparasitic, Antitumorous, Antispasmodic, Astringent, Cytotoxic, Febrifuge, Hypotensive, Insecticide, Nervine, Pectoral, Piscicide, Sedative, Stomachic, Vasodilator, Vermifuge
Phytochemicals:	Acetaldehyde, Amyl-caproate, Amyloid, Annonain, Anomuricine, Anomuricinine, Anomurine, Anonol, Atherosperminine, Beta-sitosterol, Campesterol, Cellobiose, Citric-acid, Citrulline, Coclaurine, Coreximine, Dextrose, Ethanol, Folacin, Fructose, Gaba, Galactomannan, Geranyl-caproate Glucose, HCN, Isocitric-acid, Lignoceric-acid, Malic-acid, Manganese, Mericyl-alcohol, Methanol, Methyl-hex-2-enoate, Methyl-hexanoate, Muricine, Muricinine, Muricapentocin, Muricoreacin, Myristic-acid, P-coumaric-acid, Paraffin, Potassium-chloride, Procyanidin, Reticuline, Scyllitol, Stearic-acid, Stepharine, Stigmasterol, Sucrose, Tannin, Xylosyl-cellulose
Traditional Remedy:	One-half cup leaf infusion or bark decoction 1-3 times daily or 1-3 ml of a 4:1 tincture twice daily or 2 to 5 grams of powdered leaves in tablets or capsules twice daily.

Graviola is a small, upright evergreen tree growing 5 to 6 meters in height with large dark green and glossy leaves. It is indigenous to most of the warmest tropical areas in South and North America including the Amazon. It produces a large heart-shaped edible fruit that is 6-9", yellow green in color, with white flesh. The fruit is sold in local markets in the tropics where it is called Guanabana or Brazilian Cherimoya and is excellent for making drinks and sherbets and, though slightly sour-acid, can be eaten out-of-hand. 

All parts of the Graviola tree are used in natural medicine in the tropics including the bark, leaves, roots, fruit and fruit-seeds. Different properties and uses are attributed to the different parts of the tree. Generally the fruit and fruit juice is taken for worms and parasites, to cool fevers, to increase mother's milk after childbirth (lactagogue), and as an astringent for diarrhea and dysentery. The crushed seeds are used as a vermifuge and anthelmintic against internal and external parasites and worms. The bark, leaves and roots are considered sedative, antispasmodic, hypotensive and nervine and a tea is made for various disorders for those purposes. Graviola leaves are used throughout the West Indies for their sedative or soporific properties and a decoction of the young shoots or leaves is regarded as a remedy for gall bladder trouble, as well as coughs, catarrh, diarrhea, dysentery and indigestion. In Ecuador leaves are taken as an analgesic and antispasmodic Mashed fresh leaves are used as a poultice to alleviate eczema and other skin afflictions and rheumatism, and the sap of young leaves is put on skin eruptions. 

Graviola has a long rich history of use in herbal medicine as well as a long recorded indigenous use. In the Peruvian Andes, a leaf tea is used for catarrh and the crushed seed is used to kill parasites In the Peruvian Amazon the bark roots and leaves are used for diabetes and as a sedative and antispasmodic. Indigenous tribes in Guyana use a leaf and/or bark tea of Graviola as a sedative and heart tonic. In the Brazilian Amazon, a leaf tea is used for liver problems and the oil of the leaves and unripe fruit is mixed with olive oil and used externally for neuralgia, rheumatism and arthritis pain. In Jamaica, Haiti and the West Indies, the fruit and/or fruit juice is used for fevers, parasites, as a lactagogue, and diarrhea; and the bark or leaves are used as an antispasmodic, sedative, and nervine for heart conditions, coughs, grippe, difficult childbirth, asthma, asthenia, hypertension and parasites. 

Many bioactive compounds and phytochemicals have been found in Graviola as scientists have been studying its properties since the 1940's. Its many uses in natural medicine has been validated by this scientific research. The earliest studies were between 1941 and 1962. Several studies by different researchers demonstrated that the bark as well as the leaves had hypotensive, antispasmodic, vasodilator, smooth muscle relaxant and cardiodepressant activities in animals. Researchers re-verified Graviola leaf's hypotensive properties in rats again in 1991. Several studies over the years have demonstrated that leaf, bark, root, stem and seed extracts of Graviola are antibacterial in vitro against numerous pathogens and that the bark has antifungal properties. Graviola seeds demonstrated active antiparasitic properties in a 1991 study, and a leaf extract showed to be active against malaria in two other studies in 1990 and 1993. The leaves, root, and seeds of Graviola demonstrated insecticidal properties with the seed demonstrating strong insecticidal activity in a early 1940 study. In a new 1997 clinical study, novel alkaloids were found in Graviola fruit with anti-depressive effects in animals. 



In an 1976 plant screening program by the National Cancer Institute, the leaves and stem of Graviola showed active cytotoxicity against cancer cells and researchers have been following up on this research ever since. Much of the research on Graviola focuses on a novel set of phytochemicals called annonaceous acetogenins. The potent antitumor, pesticidal and/or insect antifeedant properties of these annonaceous acetogenins have been reported and patented. Graviola produces these natural compounds in leaf, bark and twig tissues, and they have be documented to possess both highly anti-tumor and pesticidal properties. Mode of action studies in three separate laboratories have recently determined that acetogenins are superb inhibitors of Complex I in mitochondrial electron transport systems from several organisms including tumors. Research on various Annona species of plants has yielded many extremely potent acetogenins. Many of them have cytotoxicity with ED50 values as low as 10-9 ug/ml. Active compounds from Graviola and other Annona plants have been submitted to the NIH anti-AIDS screen by Purdue University and their work is continuing with a number of other active plant species in the Annona plant family. Thus far, Purdue and/or it's staff have filed at least 9 U.S. and/or international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins. Three separate research groups have isolated novel compounds in the seeds and leaves of Graviola which have demonstrated significant anti-tumorous, anticancerous and selective toxicity against various types of cancer cells, publishing 8 clinical studies on their findings. One study demonstrated that an acetogenin in Graviola was selectively cytotoxic to colon adenocarcinoma cells in which it was 10,000 times the potency of adriamycin (a chemotherapy drug). Cancer research is ongoing on Graviola, and four new studies have been published in 1998 which further narrow down the specific phytochemicals which are demonstrating the strongest anticancerous and antiviral properties. 

Annonaceous acetogenins are only found in the Annonaceae family. In general, various annonaceous acetogenins have been documented with antitumor, antiparasitic, pesticidal, antiprotozoal, antifeedant, anthelmintic, and antimicrobial activities. There has been much interest in the chemicals which have demonstrated potent antitumor properties and several research groups are trying to synthesize these chemicals for new chemotherapeutic drugs. In a review of these natural chemicals in The Journal of Natural Products in 1999 they noted: "The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms." 

Another review in the Skaggs Scientific Report 1997-1998 states, "Annonaceous acetogenins, particularly those with adjacent bis-tetrahydrofuran (THF) rings, have remarkable cytotoxic, antitumor, antimalarial, immunosuppressive, pesticidal, and antifeedant activities. Many of these fatty acid derivatives have similar carbon skeletons; their striking diversity originates mainly from the relative and absolute configuration of their various stereogenic oxygen functions." 

Purdue University has conducted a great deal of research on annonaceaous acetogenins, much of which has been funded by The National Cancer Institute and/or the National Institute of Health. In one of their reviews titled Recent Advances in Annonaceous Acetogenins, they state: "Annonaceous acetogenins are waxy substances consisting of C32 or C34 long chain fatty acids which have been combined with a 2-propanol unit at C-2 to form a lactone. They are only found in several genera of the plant family, Annonaceae. Their diverse bioactivities as antitumor, immunosuppressive, pesticidal, antiprotozoal, antifeedant, anthelmintic, and antimicrobial agents, have attracted more and more interest worldwide. Recently, we reported that the Annonaceous acetogenins can selectively inhibit the growth of cancerous cells and also inhibit the growth of adriamycin resistant tumor cells. As more acetogenins have been isolated and additional cytotoxicity assays have been conducted, we have noticed that, although most of acetogenins have high potencies among several solid human tumor cell lines, some of the derivatives within the different structural types and some positional isomers showed remarkable selectivities among certain cell lines, e.g., against prostate cancer (PC-3). We now understand the primary modes of action for the acetogenins. They are potent inhibitors of NADH: ubiquinone oxidoreductase, which is in an essential enzyme in complex I leading to oxidative phosphorylation in mitochondria. A recent report showed that they act directly at the ubiquinone-catalytic site(s) within complex I and in microbial glucose dehydrogenase. They also inhibit the ubiquinone-linked NADH oxidase that is peculiar to the plasma membranes of cancerous cells." 

In 1997, Purdue University published information with promising news that several of the Annonaceous acetogenins: "not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells." In several interviews after this information was publicized, the head Purdue pharmacologist in Purdue's research explains that cancer cells that survive chemotherapy may develop resistance to the agent originally used against them as well as to other, even unrelated, drugs. "The term multi-drug resistance (MDR) has been applied to this phenomenon," he says. He explains that such resistance develops in a small percentage of cancer cells when they develop a "P-glycoprotein mediated pump" capable of pushing anti-cancer agents out of the cell before they can kill it. Normal cells seldom develop such a pump. 

"If having this pump was such a good deal, all cells would have it. But all cells don't," the Purdue researcher says. "In a given population of cancer cells in a person, maybe only 2% of the cancer cells possess this pump. But it's those 2% of cancer cells that eventually grow and expand to create drug-resistant tumors." They go on to say that some studies have tried to bypass these pumps by keeping them busy with massive doses of other drugs, like the blood pressure agent verapamil. In this way, it was hoped that some of the anti-cancer drugs would enter the cell and destroy it. But this only caused potentially fatal side effects such as loss of blood pressure. 

In the June issue of Cancer Letters, the Purdue researchers reported that the Annonaceous acetogenin, bullatacin, preferentially killed multi-drug resistant cancer cells because it blocked production of adenosine triphosphate, ATP -- the chief energy-carrying compound in the body. "A multi-drug resistant cell requires a tremendous amount of energy to run the pump and extrude things out of the cell," Purdue head pharmacolgist says. "By inhibiting ATP production, we're essentially pulling the plug on its energy source." But what about the effect on ATP in normal cells? "Normal cells and standard cancer cells may be able to minimize the effect of this compound because they don't require vast amounts of energy needed by the pump-running cells," the Purdue researcher says. "The resistant cell is using its extra energy for this pump as well as to grow, so it is really taxed for energy. When we mess with the energy supply, it kills the cell." 

In the June issue of the Journal of Medicinal Chemistry, Purdue researchers described a study of 14 Annona compounds that seem to be potent ATP blockers, including several found only in Graviola. "This study tells us how to maximize this activity, so we have a pretty good idea what compounds we'd like to try in animals with multi-drug resistant tumors," they say. Cancer research will obviously be ongoing on these important plants and plant chemicals as several pharmaceutical companies and universities continue to research, test, patent and attempt to synthesize these chemicals into new chemotheraputic drugs. 

Country	ETHNOBOTANY: WORLDWIDE USES
Bahamas	Chill, Fever, Flu, Nervousness, Palpitation, Rash, Sedative, Skin Disease
Brazil	Analgesic, Fever, Neuralgia, Parasites, Rheumatism
Curacao	Childbirth, Gall-Bladder, Nervousness, Parturition Sedative, Tea, Tranquilizer
Elsewhere	Analgesic, Arthritis, Asthma, Astringent, Antiphlogistic, Dysentery, Febrifuge, Insecticide,Cyanogenetic, Kidney, Lactagogue, Malaria, Pectoral, Pediculicide, Piscicide, Scurvy Stomach,
Haiti	Asthenia, Cataplasm, Cicatrizant, Cough, Diarrhea, Emetic, Grippe, Pediculicide, Pellagra, Soporific, Sore, Spasm, Stomachic,
Jamaica	Antispasmodic, Diuretic, Fevers, Lactagogue, Vermifuge
Malaya	Boil, Cough, Dermatosis, Rheumatism
Mexico	Astringent, Diarrhea, Dysentery, Fever, Liqueur, Pectoral, Ringworm, Scurvy
Panama	Anthelmintic, Diarrhea, Dyspepsia, Internulcer, Kidney, Piscicide, Ulcer(stomach), Vermifuge
Trinidad	Depurative , Fainting, Flu, Hypertension, Glactagogue, High Blood Pressure, Insomnia, Palpitation, Ringworms
Venezuela	Bilious, Diarrhea
West Indies	Childbirth, Diarrhea, Hypertension, Lactagogue, Worms

References:

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DATA-MEDICOS/DERMAGIC-EXPRESS No 4-(116)  05/09/2.002 DR. JOSE LAPENTA R. 
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