M.Sc., Bioinformatics (CBCS)
(For the students admitted during the academic year 2004-2005)
Scheme of examination
(With project work) - (CBCS – Bharathiar University Department)

Semester II:

Paper I: Genomics
Genome map - Types of map and their uses, Map repositories, Linkage map resources, Practical uses of genome maps, Annotation of Genome - Structural annotation, Various approaches in gene prediction, Functional gene prediction, Genomic diversity, Salient features, Statistical information, size, Biology, Taxonomy and significance, General purpose comparative genomic databases, Human genome and Genomic Analysis – Size, Features, Composition and characteristics of human genome, Genome analysis, Comparative Genomics – Purpose and methods of comparison, Tools for genomic comparison, Applications of comparative genomics.

Paper II: Proteomics
Protein classification – Structural elements and terminology, Principles of classification, Protein structure prediction – Use of sequence pattern, Secondary structure prediction, Proteome analysis – 2D Electrophoresis, Detecting protein on gel, Data analysis, Functional proteomics – Integrated proteome analysis, Automation of proteomic analysis, Proteomics in plant breeding – Brief introduction to plant breeding: Objectives, Principles and methods.

Paper III: Molecular Modelling and Computer Aided Drug Design
Introduction to the concepts of molecular modeling, Techniques of molecular dynamics ad Monte Carlo simulation, Abinitio, dft and semi empirical methods, Macromolecular modelling, Finding new drug targets to treat disease, Structure based drug design for all classes of targets.

Paper IV: Systems Biology
Functional Genomics – Developmental Biology and Differential expression of Genes, Methods of study, Microarray, Microarray analysis, Metabolic genotype – Central metabolism, Translating biochemical networks into linear algebra, Whole cell simulation – Principle and levels of simulation, Relation ship analysis, Creative Bioinformatics – Novel use of Database.

Semester IV:
Project Work

Practical III: Computer Aided Drug Designing
Small molecule building with ISIS DRAW, CHEM SKETCH, Homology Modelling using SPDBV, Model structure refinement using SPDBV, Model validation using What Check and Pro check, Docking using DOCK or AUTODOCK or AMBER, Virtual Screening using NCI Database.